Mucosal HIV-1 Pox Virus Prime-Boost Immunization Induces High-Avidity CD8+ T Cells with Regime-Dependent Cytokine/Granzyme B Profiles

NK CELL RECEPTORS

1998 • 1,666 citations

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1997 • 1,206 citations

Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential

2005 • 1,169 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine

2001 • 1,128 citations

Allelic inactivation regulates olfactory receptor gene expression

1994 • 1,056 citations

The Mechanism and Regulation of Chromosomal V(D)J Recombination

2002 • 931 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

NALT- versus PEYER'S-patch-mediated mucosal immunity

2004 • 684 citations

Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus

2004 • 562 citations

Expression of Mouse Interleukin-4 by a Recombinant Ectromelia Virus Suppresses Cytolytic Lymphocyte Responses and Overcomes Genetic Resistance to Mousepox

2001 • 550 citations

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

1992 • 536 citations

Transcriptional Control of Early B Cell Development

2004 • 479 citations

Isolation of High Avidity Melanoma-Reactive CTL from Heterogeneous Populations Using Peptide-MHC Tetramers

1999 • 423 citations

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

1997 • 411 citations

Gene Repression by Pax5 in B Cells Is Essential for Blood Cell Homeostasis and Is Reversed in Plasma Cells

2006 • 354 citations

Cutting Edge: Gut Microenvironment Promotes Differentiation of a Unique Memory CD8 T Cell Population

2006 • 351 citations

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

1998 • 314 citations

Reversion of B Cell Commitment upon Loss of Pax5 Expression

2002 • 285 citations

Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection.

1994 • 276 citations

Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge

1998 • 265 citations

Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen

2000 • 259 citations

Pax5/BSAP Maintains the Identity of B Cells in Late B Lymphopoiesis

2001 • 246 citations

Transcriptional networks in developing and mature B cells

2005 • 235 citations

Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors

2005 • 234 citations

Monoallelic Expression of the Interleukin-2 Locus

1998 • 232 citations

Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL.

1996 • 222 citations

A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humans

2004 • 214 citations

High-Avidity CTL Exploit Two Complementary Mechanisms to Provide Better Protection Against Viral Infection Than Low-Avidity CTL

2001 • 207 citations

Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential

2003 • 205 citations

Hierarchies in Cytokine Expression Profiles for Acute and Resolving Influenza Virus-Specific CD8+ T Cell Responses: Correlation of Cytokine Profile and TCR Avidity

2004 • 203 citations

Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow

2005 • 163 citations

Regulation of Expression of IL-4 Alleles

2001 • 147 citations

Impact of vaccine-induced mucosal high-avidity CD8+CTLs in delay of AIDS viral dissemination from mucosa

2005 • 140 citations

Coordinate Regulation of the IL-4, IL-13, and IL-5 Cytokine Cluster in Th2 Clones Revealed by Allelic Expression Patterns

2000 • 139 citations

IL-2 Regulates Perforin and Granzyme Gene Expression in CD8+ T Cells Independently of Its Effects on Survival and Proliferation

2005 • 138 citations

Immunology 101 at poxvirus U: Immune evasion genes

2001 • 136 citations

Immunobiology of Mucosal HIV Infection and the Basis for Development of a New Generation of Mucosal AIDS Vaccines

2004 • 132 citations

Analysis of Clonotype Distribution and Persistence for an Influenza Virus-Specific CD8+ T Cell Response

2003 • 132 citations

Computational and Biological Analysis of 680 kb of DNA Sequence from the Human 5q31 Cytokine Gene Cluster Region

1997 • 126 citations

Theileria parvacandidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes

2006 • 125 citations

Dosage requirement and allelic expression of PAX6 during lens placode formation

2000 • 121 citations

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine

2001 • 118 citations

Antigen Density Presented By Dendritic Cells In Vivo Differentially Affects the Number and Avidity of Primary, Memory, and Recall CD8+ T Cells

2003 • 113 citations

Interleukin-12 (IL-12) Enhancement of the Cellular Immune Response against Human Immunodeficiency Virus Type 1 Env Antigen in a DNA Prime/Vaccinia Virus Boost Vaccine Regimen Is Time and Dose Dependent: Suppressive Effects of IL-12 Boost Are Mediated by Nitric Oxide

2000 • 113 citations

The MHC Class I-Restricted Immune Response to HIV-gag in BALB/c Mice Selects a Single Epitope That Does Not Have a Predictable MHC-Binding Motif and Binds to Kd Through Interactions Between a Glutamine at P3 and Pocket D

1998 • 103 citations

CD8+ CTLs Are Essential for Protective Immunity Against Encephalitozoon cuniculi Infection

1999 • 95 citations

Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBP and GATA factors

2003 • 92 citations

A push–pull approach to maximize vaccine efficacy: Abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L

2002 • 91 citations

Enhanced CD8+ T Cell Immune Responses and Protection Elicited against Plasmodium berghei Malaria by Prime Boost Immunization Regimens Using a Novel Attenuated Fowlpox Virus

2004 • 89 citations

Multiple-cloning-site plasmids for the rapid construction of recombinant poxviruses

1985 • 85 citations

Probabilistic Regulation in TH2 Cells Accounts for Monoallelic Expression of IL-4 and IL-13

2005 • 77 citations

A Clonal Culture System Demonstrates That IL-4 Induces a Subpopulation of Noncytolytic T Cells with Low CD8, Perforin, and Granzyme Expression

2002 • 77 citations

Prime-Boost Immunization Schedules Based on Influenza Virus and Vaccinia Virus Vectors Potentiate Cellular Immune Responses against Human Immunodeficiency Virus Env Protein Systemically and in the Genitorectal Draining Lymph Nodes

2003 • 75 citations

High-avidity CD8+ T cells

2004 • 74 citations

Expression of Secreted Cytokine and Chemokine Inhibitors by Ectromelia Virus

2000 • 70 citations

Vaccinia Virus Induces Strong Immunoregulatory Cytokine Production in Healthy Human Epidermal Keratinocytes: a Novel Strategy for Immune Evasion

2005 • 67 citations

A Phase II Study of Two HIV Type 1 Envelope Vaccines, Comparing Their Immunogenicity in Populations at Risk for Acquiring HIV Type 1 Infection

2000 • 64 citations

Contribution of T cell receptor affinity to overall avidity for virus-specific CD8⁺T cell responses

2005 • 64 citations

Monitoring of cellular responses after vaccination against tetanus toxoid: Comparison of the measurement of IFN-γ production by ELISA, ELISPOT, flow cytometry and real-time PCR

2005 • 63 citations

Enhancement of Primary and Secondary Cellular Immune Responses against Human Immunodeficiency Virus Type 1 Gag by Using DNA Expression Vectors That Target Gag Antigen to the Secretory Pathway

2000 • 63 citations

Mucosally-administered human–simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3

2005 • 61 citations

The combination of DNA vectors expressing IL-12 + IL-18 elicits high protective immune response against cutaneous leishmaniasis after priming with DNA-p36/LACK and the cytokines, followed by a booster with a vaccinia virus recombinant expressing p36/LACK

2003 • 61 citations

A single peripheral CD8⁺T cell can give rise to progeny expressing type 1 and/or type 2 cytokine genes and can retain its multipotentiality through many cell divisions

1997 • 61 citations

Evaluation of fowlpox–vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1

2006 • 55 citations

Analysis of intergenic transcription in the human IL-4/IL-13 gene cluster

2004 • 53 citations

Evaluation in macaques of HIV-1 DNA vaccines containing primate CpG motifs and fowlpoxvirus vaccines co-expressing IFN? or IL-12

2004 • 47 citations

Fowlpox virus vaccines for HIV and SHIV clinical and pre-clinical trials

2005 • 44 citations

Construction of recombinant fowlpox viruses carrying multiple vaccine antigens and immunomodulatory molecules

2004 • 43 citations

Profiling the CD8^low phenotype, an alternative career choice for CD8 T cells during primary differentiation

2004 • 36 citations

Simian Immunodeficiency Virus (SIV)-Specific CTL Are Present in Large Numbers in Livers of SIV-Infected Rhesus Monkeys

2000 • 35 citations

4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine

2006 • 34 citations

Optimal kinetics for quantification of antigen-induced cytokines in human peripheral blood mononuclear cells by real-time PCR and by ELISA

2003 • 34 citations

Heterologous Priming-Boosting Immunization of Cattle withMycobacterium tuberculosis85A Induces Antigen-Specific T-Cell Responses

2003 • 29 citations

Flow cytometric determination of cytokine production and proliferation in Hepatitis B core antigen specific murine CD4 cells: lack of correlation between number of cytokine producing cells and cytokine levels in supernatant

2001 • 15 citations

Can Vaccine-induced Mucosal High Avidity CD8+ CTL Delay AIDS-viral Dissemination from Mucosa?

2005 • 1 citations