The T cell repertoire in infection and vaccination: implications for control of persistent viruses

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

2006 • 1,485 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

Initial T cell frequency dictates memory CD8+ T cell lineage commitment

2005 • 458 citations

Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses

2005 • 374 citations

Dendritic Cells Maximize the Memory CD8 T Cell Response to Infection

2005 • 320 citations

Stimulation History Dictates Memory CD8 T Cell Phenotype: Implications for Prime-Boost Vaccination

2006 • 311 citations

A structural basis for immunodominant human T cell receptor recognition

2003 • 300 citations

T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection

2004 • 279 citations

Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag

2005 • 269 citations

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I–bound peptide

2005 • 268 citations

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

2003 • 253 citations

Four Distinct Patterns of Memory CD8 T Cell Responses to Chronic Murine Cytomegalovirus Infection

2006 • 240 citations

High-Avidity CTL Exploit Two Complementary Mechanisms to Provide Better Protection Against Viral Infection Than Low-Avidity CTL

2001 • 207 citations

Differential Antigen Presentation Regulates the Changing Patterns of CD8+ T Cell Immunodominance in Primary and Secondary Influenza Virus Infections

2003 • 207 citations

A Novel Approach to the Analysis of Specificity, Clonality, and Frequency of HIV-Specific T Cell Responses Reveals a Potential Mechanism for Control of Viral Escape

2002 • 203 citations

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection

2006 • 186 citations

Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination

2006 • 182 citations

Clonal Selection of Helper T Cells Is Determined by an Affinity Threshold with No Further Skewing of TCR Binding Properties

2004 • 171 citations

CD8⁺T-Lymphocyte Response to Major Immunodominant Epitopes after Vaginal Exposure to Simian Immunodeficiency Virus: Too Late and Too Little

2005 • 163 citations

T Cell Cross-Reactivity and Conformational Changes during TCR Engagement

2004 • 160 citations

Lack of prominent peptide–major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

2005 • 150 citations

Evolution of diverse antiviral CD8⁺ T cell populations after murine cytomegalovirus infection

2005 • 148 citations

Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection

2005 • 142 citations

Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity

2006 • 138 citations

De Novo Generation of Escape Variant-Specific CD8⁺T-Cell Responses following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection

2005 • 133 citations

Antigen Density Presented By Dendritic Cells In Vivo Differentially Affects the Number and Avidity of Primary, Memory, and Recall CD8+ T Cells

2003 • 113 citations

Kinetics of Virus-Specific CD8⁺T Cells and the Control of Human Immunodeficiency Virus Infection

2004 • 108 citations

HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently

2006 • 106 citations

HIV-specific Cytotoxic T Cells from Long-Term Survivors Select a Unique T Cell Receptor

2004 • 104 citations

Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

2006 • 102 citations

CTL Recognition of a Bulged Viral Peptide Involves Biased TCR Selection

2005 • 98 citations

Clonal Selection, Clonal Senescence, and Clonal Succession: The Evolution of the T Cell Response to Infection with a Persistent Virus

2002 • 97 citations

Loss of Viral Control in Early HIV‐1 Infection Is Temporally Associated with Sequential Escape from CD8⁺T Cell Responses and Decrease in HIV–1–Specific CD4⁺and CD8⁺T Cell Frequencies

2004 • 73 citations

Late Priming and Variability of Epitope-Specific CD8+ T Cell Responses during a Persistent Virus Infection

2005 • 73 citations

T Cell Receptor Recognition via Cooperative Conformational Plasticity

2006 • 64 citations

Contribution of T cell receptor affinity to overall avidity for virus-specific CD8⁺T cell responses

2005 • 64 citations

Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection

2006 • 61 citations

Kinetics of TCR Use in Response to Repeated Epitope-Specific Immunization

2001 • 58 citations

Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire

2005 • 53 citations

Cutting Edge: Regulation of CD8+ T Cell Effector Population Size

2004 • 45 citations

Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques

2005 • 42 citations

Role of Thymic Output in Regulating CD8 T-Cell Homeostasis during Acute and Chronic Viral Infection

2005 • 41 citations

Complex T Cell Memory Repertoires Participate in Recall Responses at Extremes of Antigenic Load

2006 • 40 citations

High-Potency Human Immunodeficiency Virus Vaccination Leads to Delayed and Reduced CD8 ⁺ T-Cell Expansion but Improved Virus Control

2005 • 28 citations

T-cell grit: large clonal expansions of virus-specific CD8+ T cells can dominate in the peripheral circulation for at least 18 years

2005 • 24 citations

A Highly Restricted T-Cell Receptor Dominates the CD8⁺T-Cell Response to Parvovirus B19 Infection in HLA-A*2402-Positive Individuals

2006 • 21 citations

Longitudinal Analysis of Herpes Simplex Virus–Specific CD4⁺Cell Clonotypes in Infected Tissues and Blood

2005 • 14 citations