The 20S proteasome mediates the degradation of mouse and yeast ornithine decarboxylase in yeast cells

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

1992 • 780 citations

Purification of two high molecular weight proteases from rabbit reticulocyte lysate.

1987 • 542 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.

1991 • 421 citations

Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome)

1988 • 404 citations

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

1989 • 370 citations

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

1990 • 327 citations

A high molecular weight protease in the cytosol of rat liver. I. Purification, enzymological properties, and tissue distribution.

1986 • 327 citations

Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates.

1987 • 255 citations

Prevention of Rapid Intracellular Degradation of ODC by a Carboxyl-Terminal Truncation

1989 • 247 citations

The multicatalytic proteinase of mammalian cells

1989 • 242 citations

Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate.

1992 • 229 citations

Proteasomes (multi-protease complexes) as 20 S ring-shaped particles in a variety of eukaryotic cells.

1988 • 225 citations

Purification and characterization of a multicatalytic high-molecular-mass proteinase from rat skeletal muscle

1985 • 208 citations

Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase

1988 • 179 citations

Involvement of the proteasome in various degradative processes in mammalian cells.

1989 • 162 citations

The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis.

1993 • 149 citations

In vivo function of the proteasome in the ubiquitin pathway.

1992 • 144 citations

Degradation of Ornithine Decarboxylase in Reticulocyte Lysate Is ATP-dependent but Ubiquitin-independent

1989 • 139 citations

Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent

1989 • 93 citations

The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae.

1987 • 85 citations

The proteasome/multicatalytic—multifunctional proteinase In vivo function in the ubiquitin‐dependent N‐end rule pathway of protein degradation in eukaryotes

1992 • 76 citations

A 20S particle ubiquitous from yeast to human

1987 • 67 citations

Proteinase yscE of yeast shows homology with the 20 S cylinder particles of Xenopus laevis

1988 • 66 citations

[27] High-efficiency yeast expression vectors based on the promoter of the phosphoglycerate kinase gene

1990 • 63 citations

Characterization of sequences involved in mediating degradation of ornithine decarboxylase in cells and in reticulocyte lysate

1991 • 57 citations

Mos is degraded by the 26S proteasome in a ubiquitin‐dependent fashion

1993 • 56 citations

Regulation of Saccharomyces cerevisiae ornithine decarboxylase expression in response to polyamine

1989 • 39 citations

Involvement of the 20S proteasome in the degradation of ornithine decarboxylase

1993 • 29 citations