Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiationin vitro

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin)

1948 • 1,702 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

EXPERIMENTAL EVALUATION OF POTENTIAL ANTICANCER AGENTS. XIII. ON THE CRITERIA AND KINETICS ASSOCIATED WITH "CURABILITY" OF EXPERIMENTAL LEUKEMIA.

1964 • 763 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

1984 • 521 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

1989 • 409 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

Experimental evaluation of potential anticancer agents VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia.

1963 • 369 citations

Induction of Multidrug Resistance in Human Cells by Transient Exposure to Different Chemotherapeutic Drugs

1993 • 366 citations

Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.

1987 • 343 citations

Modulation of multidrug-resistant multiple myeloma by cyclosporin

1992 • 317 citations

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1994 • 315 citations

Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity

1976 • 314 citations

Role of the Glutathione Redox Cycle in Acquired and de Novo Multidrug Resistance

1988 • 301 citations

Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells.

1987 • 296 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme.

1987 • 282 citations

Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.

1986 • 275 citations

Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line.

1987 • 266 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Characteristics of resistance to adriamycin in human myelogenous leukemia K562 resistant to adriamycin and in isolated clones.

1986 • 231 citations

Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).

1987 • 229 citations

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1984 • 225 citations

Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein.

1990 • 223 citations

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26

1988 • 223 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line MES-SA.

1985 • 210 citations

Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia.

1988 • 196 citations

Multidrug-resistance phenotype in Chinese hamster ovary cells.

1983 • 194 citations

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.

1991 • 187 citations

Systemic Toxic Effects Associated With High-Dose Verapamil Infusion and Chemotherapy Administration

1991 • 185 citations

The role of the MDR1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo

1992 • 183 citations

Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells.

1987 • 180 citations

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

1985 • 176 citations

Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: Evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II

1992 • 171 citations

Genes amplified and overexpressed in human multidrug-resistant cell lines.

1988 • 170 citations

Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line

1991 • 165 citations

P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines

1992 • 157 citations

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.

1990 • 157 citations

Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line

1991 • 156 citations

Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines.

1988 • 154 citations

Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II .beta. isoform

1991 • 153 citations

Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines.

1993 • 153 citations

Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257.

1990 • 148 citations

Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein

1993 • 147 citations

Alteration of plasma membrane glycopeptides and gangliosides of Chinese hamster cells accompanying development of resistance to daunorubicin and vincristine.

1983 • 146 citations

Combined modalities of resistance in etoposide-resistant human KB cell lines.

1988 • 146 citations

P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines.

1989 • 144 citations

Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.

1990 • 143 citations

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance.

1992 • 140 citations

Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA.

1993 • 138 citations

Derivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells

1986 • 123 citations

Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells

1990 • 122 citations

Adriamycin resistance in HL60 cells in the absence of detectable P-glycoprotein

1987 • 122 citations

Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.

1990 • 121 citations

Mechanisms of multidrug resistance in HL60 cells: evidence that a surface membrane protein distinct from P-glycoprotein contributes to reduced cellular accumulation of drug.

1988 • 121 citations

Overexpression of P-glycoprotein in Mammalian Tumor Cell Lines After Fractionated X Irradiation In Vitro

1990 • 118 citations

Mechanisms of multidrug resistance in HL60 cells: detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein.

1990 • 116 citations

Cross resistance between vinca alkaloids and anthracyclines in Ehrlich ascites tumor in vivo.

1972 • 115 citations

Cellular resistance to daunomycin in Chinese hamster cells in vitro.

1971 • 113 citations

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines.

1986 • 113 citations

Multidrug resistance mediated by P-glycoproteins.

1991 • 113 citations

Biosynthesis of heterogeneous forms of multidrug resistance-associated glycoproteins.

1987 • 110 citations

Unknotting the Complexities of Multidrug Resistance: The Involvement of DNA Topoisomerases in Drug Action and Resistance

1989 • 107 citations

Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression

1992 • 100 citations

Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells.

1985 • 100 citations

Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines.

1988 • 99 citations

Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: evidence for nuclear drug accumulation and redistribution in resistant cells.

1992 • 94 citations

Markedly altered membrane transport and intracellular binding of vincristine in multidrug‐resistant Chinese hamster cells selected for resistance to vinca alkaloids

1986 • 94 citations

Optimization of immunocytochemical P-glycoprotein assessment in multidrug-resistant plasma cell myeloma using three antibodies.

1990 • 90 citations

Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate

1992 • 85 citations

Resistance to Antineoplastic Drugs

1990 • 81 citations

Vincristine‐resistant Human Cancer KB Cell Line and Increased Expression of Multidrug‐resistance Gene

1988 • 79 citations

DNA strand breaks produced by etoposide (VP-16,213) in sensitive and resistant human breast tumor cells: implications for the mechanism of action.

1988 • 76 citations

Retention of activity by selected anthracyclines in a multidrug resistant human large cell lung carcinoma line without P-glycoprotein hyperexpression

1991 • 66 citations

Improved cellular accumulation is characteristic of anthracyclines which retain high activity in multidrug resistant cell lines, alone or in combination with verapamil or cyclosporin A

1989 • 62 citations

Cellular pharmacology of vinca alkaloid resistance and its circumvention

1984 • 61 citations

Altered topoisomerase IIα in a drug-resistant small cell lung cancer cell line selected in VP-16

1994 • 61 citations

HT1080/DR4: A P-Glycoprotein-Negative Human Fibrosarcoma Cell Line Exhibiting Resistance to Topoisomerase II-Reactive Drugs Despite the Presence of a Drug-Sensitive Topoisomerase II

1990 • 60 citations

Sulfolipids and glycolipid sulfotransferase activities in human renal cell carcinoma cells

1993 • 58 citations

An overview of membrane, cytosolic and nuclear proteins associated with the expression of resistance to multiple drugs in vitro

1992 • 58 citations

Response of advanced breast carcinoma to the combination of the antimetabolite, Methotrexate, and the alkylating agent, thio-TEPA.

1963 • 56 citations

The 1991 Merck Frosst Award. Multidrug resistance in small cell lung cancer

1992 • 55 citations

Identification of anthracyclines and related agents that retain preferential activity over Adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A

1989 • 53 citations

Decreased expression of the amplified mdr1 gene in revertants of multidrug-resistant human myelogenous leukemia K562 occurs without loss of amplified DNA.

1987 • 51 citations

Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype.

1992 • 49 citations

Non-P-glycoprotein-mediated multidrug resistance with reduced EGF receptor expression in a human large cell lung cancer cell line

1990 • 48 citations

Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line

1993 • 46 citations

Increased ATP Requirement for Activity of and Complex Formation by DNA Topoisomerase II from Human Leukemic CCRF-CEM Cells Selected for Resistance to Teniposide

1989 • 45 citations

Establishment and properties of vincristine-resistant human myelogenous leukemia K562.

1983 • 44 citations

Structural and Functional Analyses of the Promoter of the Murine Multidrug Resistance Genemdr3/mdrlaReveal a Negative Element Containing the AP-1 Binding Site

1991 • 44 citations

Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection: decreased anthracycline uptake precedes increased P-glycoprotein expression.

1990 • 44 citations

Multiple drug-resistance in variant of a human non-small cell lung carcinoma cell line, DLKP-A

1992 • 43 citations

Over-expression of P-glycoprotein and glutathione S-transferase PI in MCF-7 cells selected for vincristine resistancein vitro

1992 • 43 citations

Biosynthesis, processing and half-life of P-glycoprotein in a human multidrug-resistant KB cell

1989 • 42 citations

The role of topoisomerase IIα and β in drug resistance

1993 • 41 citations

Characteristics of Multidrug Resistance in Human Tumor Cells

1991 • 40 citations

Sensitivity of K562 human chronic myelogenous leukemia blast cells transfected with a human multidrug resistance cDNA to cytotoxic drugs and differentiating agents.

1993 • 40 citations

Circumvention of resistance to anthracyclines by calcium antagonists and other membrane-perturbing agents.

1986 • 37 citations

Differential expression of collateral sensitivity or resistance to cisplatin in human bladder carcinoma cell lines pre‐exposed in vitro to either X‐irradiation or cisplatin

1987 • 37 citations

Interactions between antitumour agents and radiation and the expression of resistance

1991 • 36 citations

Over‐expression of MDR gene with no dna amplification in a multiple‐drug‐resistant human ovarian carcinoma cell line

1989 • 36 citations

Karnofsky memorial lecture. The oncologic end game.

1986 • 35 citations

Functional analysis of chimeric proteins constructed by exchanging homologous domains of two P-glycoproteins conferring distinct drug resistance profiles

1992 • 32 citations

Mr 85,000 membrane protein specifically expressed in adriamycin-resistant human tumor cells.

1988 • 31 citations

Establishment of an etoposide‐resistant human epithelial tumour cell line In vitro: Characterization of patterns of cross‐resistance and drug sensitivities

1984 • 31 citations

Biochemical and genetic characterization of the multidrug resistance phenotype in murine macrophage-like J774.2 cells

1992 • 31 citations

Multifactorial resistance to antineoplastic agents in drug-resistant P388 murine leukemia, Chinese hamster ovary, and human HeLa cells, with emphasis on the role of DNA topoisomerase II

1992 • 30 citations

Interactions between antitumor drugs and radiation in mammalian tumor cell lines: differential drug responses and mechanisms of resistance following fractionated X-irradiation or continuous drug exposure in vitro.

1988 • 28 citations

Topoisomerase II as a target of VM-26 and 4'-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells.

1993 • 27 citations

Establishment of vincristine-resistant and vindesine-resistant lines of murine lymphoblasts in vitro and characterisation of their patterns of cross-resistance and drug sensitivities

1982 • 27 citations

Dominant Expression of Multiple Drug Resistance After In Vitro X-irradiation Exposure in Intraspecific Chinese Hamster Ovary Hybrid Cells

1993 • 26 citations

The products of the la and lb genes from multidrug resistant murine cells have similar degradation rates

1990 • 25 citations

Expression of P-glycoprotein-mediated Drug Resistance in CHO Cells Surviving a Single X-ray Dose of 30 Gy

1993 • 25 citations

Differential expression of steroid receptors, hsp27, and pS2 in a series of drug resistant human breast tumor cell lines derived following exposure to antitumor drugs or to fractionated X-irradiation

1993 • 25 citations

Differential patterns of anti‐tumour drug responses and mechanisms of resistance in a series of independently‐derived VP‐16‐resistant human tumour cell lines

1988 • 25 citations

Acquisition of multiple drug resistance by CCRF-CEM cells selected for different degrees of resistance to vincristine.

1984 • 25 citations

Differential Amplification and Disproportionate Expression of Five Genes in Three Multidrug-Resistant Chinese Hamster Lung Cell Lines

1986 • 24 citations

Characterization of the P-glycoprotein over-expressing drug resistance phenotype exhibited by Chinese hamster ovary cells following their in-vitro exposure to fractionated X-irradiation

1993 • 23 citations

Overexpression of P-Glycoprotein in Human Lung Carcinoma Xenografts after Fractionated Irradiation in Vivo

1991 • 22 citations

Induced multidrug resistance in murine leukemia L1210 and associated changes in a surface-membrane glycoprotein

1989 • 21 citations

Cytogenetic alterations associated with P-glycoprotein- and non-P-glycoprotein-mediated multidrug resistance in SW-1573 human lung tumor cell lines

1993 • 19 citations

Cellular Concomitants of Multidrug Resistance

1988 • 19 citations

ACTIVATION OF THE HUMAN MULTIDRUG RESISTANCE-1 (MDR1) GENE PROMOTER IN RESPONSE TO INHIBITORS OF DNA TOPOISOMERASES

1992 • 17 citations

Multidrug-resistant human neuroblastoma cells are more differentiated than controls and retinoic acid further induces lineage-specific differentiation.

1991 • 16 citations

Decreased Expression of the Amplified mdr1 Gene in Revertants of Multidrug-Resistant Human Myelogenous Leukemia K562 Occurs without Loss of Amplified DNA

1987 • 15 citations

Characterization of an Etoposide‐resistant Human K562 Cell Line, K/eto

1991 • 14 citations

Expression off resistance to etoposide and vincristine in vitro and in vivo after X-irradiation of ovarian tumor cells

1992 • 14 citations

Molecular cloning and characterization of the complementary DNA for the M(r) 85,000 protein overexpressed in adriamycin-resistant human tumor cells.

1993 • 14 citations

A lack of detectable modification of topoisomerase II activity in a series of human tumor cell lines expressing only low levels of etoposide resistance

1991 • 14 citations

Time course of MDR gene amplification during in vivo selection for doxorubicin-resistance and during reversal in murine leukemia L 1210.

1991 • 13 citations

Comparative effectiveness of mitoxantrone and doxorubicin in overcoming experimentally induced drug resistance in murine and human tumour cell lines in vitro

1989 • 13 citations

Molecular analysis of two human doxorubicin-resistant cell lines: evidence for differing multidrug resistance mechanisms.

1991 • 12 citations

In vitro human tumour model systems for investigating drug resistance.

1986 • 11 citations

Murine L5178Y Cells Resulting in Altered Drug Sensitivities From Fractionated Radiation Exposure In Vitro

1984 • 10 citations

Homogeneously staining region in anthracycline-resistant HL-60/AR cells not associated with MDR1 amplification.

1992 • 7 citations

Antitumor Drug Radiation Interactions

2018 • 6 citations