Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein.

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

1984 • 1,477 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells

1982 • 578 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

1979 • 454 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1987 • 291 citations

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.

1986 • 241 citations

Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.

1984 • 231 citations

Purification and characterization of a type II DNA topoisomerase from bovine calf thymus.

1985 • 215 citations

Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action

1987 • 214 citations

Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line MES-SA.

1985 • 210 citations

Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoprotein.

1983 • 201 citations

Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia.

1988 • 196 citations

Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells.

1987 • 191 citations

A phosphoglycoprotein associated with taxol resistance in J774.2 cells.

1985 • 158 citations

Isolation and characterization of an anthracycline-resistant human leukemic cell line.

1985 • 137 citations

Detection and mapping of homologous, repeated and amplified DNA sequences by DNA renaturation in agarose gets

1983 • 135 citations

DRUG RESISTANCE AND MEMBRANE ALTERATION IN MUTANTS OF MAMMALIAN CELLS

1975 • 129 citations

Mechanisms of Drug Resistance in Neoplastic Cells

1988 • 114 citations

Cellular resistance to daunomycin in Chinese hamster cells in vitro.

1971 • 113 citations

Topoisomerase II-mediated DNA breaks and cytotoxicity in relation to cell proliferation and the cell cycle in NIH 3T3 fibroblasts and L1210 leukemia cells.

1987 • 109 citations

Alterations in cell surface membranes in chinese hamster lung cells resistant to adriamycin

1982 • 84 citations

Characterization of a camptothecin-resistant human DNA topoisomerase I.

1988 • 82 citations

Inhibition of mitochondrial oxidative phosphorylation by adriamycin

1983 • 80 citations

Cell surface-mediated cytotoxicity of polymer-bound Adriamycin against drug-resistant hepatocytes.

1983 • 75 citations

Membrane alterations associated with progressive adriamycin resistance

1982 • 70 citations

Purification of a tyrosine-specific protein kinase from Rous sarcoma virus-induced rat tumor.

1982 • 69 citations

Growth-related elevations of DNA topoisomerase II levels found in Dunning R3327 rat prostatic adenocarcinomas.

1987 • 64 citations

Transport and storage of daunorubicin and doxorubicin in cultured fibroblasts.

1978 • 62 citations

Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein.

1985 • 58 citations

Studies of topoisomerase-specific antitumor drugs in human lymphocytes using rabbit antisera against recombinant human topoisomerase II polypeptide.

1989 • 56 citations

Dissociation of Antitumor Potency from Anthracycline Cardiotoxicity in a Doxorubicin Analog

1985 • 49 citations

Cytofluorescence localization of anthracycline antibiotics.

1980 • 46 citations

Isolation and preliminary characterization of an Adriamycin-resistant murine fibrosarcoma cell line.

1983 • 45 citations

Uptake and retention of morpholinyl anthracyclines by adriamycin-sensitive and-resistant P388 cells

1986 • 41 citations

Mr 85,000 membrane protein specifically expressed in adriamycin-resistant human tumor cells.

1988 • 31 citations

DNA Cross-linking and Cytotoxicity of the Alkylating Cyanomorpholino Derivative of Doxorubicin in Multidrug-Resistant Cells2

1988 • 27 citations

Doxorubicin and the Alkylating Anthracycline 3'-Deamino-3'-(3-cyano-4-morpholinyl) doxorubicin: Comparative In Vitro Potency Against Leukemia and Bone Marrow Cells

1988 • 14 citations

Mutant KB cells with decreased EGF receptor expression: Biochemical characterization

1987 • 10 citations

Subcellular distribution of adriamycin in the liver and tumor of 3LL-bearing mice

1983 • 7 citations