Identification of anthracyclines and related agents that retain preferential activity over Adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

1988 • 3,038 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity

1987 • 940 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Studies on succinate-tetrazolium reductase systems

1963 • 737 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

1979 • 454 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Rapid chemosensitivity testing of human lung tumor cells using the MTT assay

1986 • 289 citations

Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors.

1983 • 250 citations

Uptake and retention of adriamycin and daunorubicin by sensitive and anthracycline-resistant sublines of P388 leukemia

1978 • 212 citations

Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multi-drug resistant human lung cancer cell line

1987 • 205 citations

Anthracycline analogs The past, present, and future

1986 • 185 citations

Cyclosporin A corrects daunorubicin resistance in Ehrlich ascites carcinoma

1986 • 147 citations

Modification of cytotoxic drug resistance by non-immuno-suppressive cyclosporins

1988 • 125 citations

Derivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells

1986 • 123 citations

Carrier-mediated transport of daunorubicin, adriamycin, and rubidazone in ehrlich ascites tumour cells

1978 • 121 citations

Tumour cell resistance to anthracyclines ? A review

1985 • 120 citations

Properties of antitumor anthracyclines and new developments in their application: Cain memorial award lecture.

1985 • 117 citations

Increase in Nonspecific Adsorptive Endocytosis in Anthracycline-and Vinca Alkaloid-Resistant Ehrlich Ascites Tumor Cell Lines2

1987 • 87 citations

Anthrapyrazoles, a new class of intercalating agents with high-level, broad spectrum activity against murine tumors.

1985 • 87 citations

Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil

1987 • 79 citations

Mechanism of Action: In vitro Studies

1986 • 62 citations

Enhancement by cyclosporin A of daunorubicin efficacy in Ehrlich ascites carcinoma and murine hepatoma 129.

1987 • 52 citations

Potentiation of antitumor agents by calcium channel blockers with special reference to cross-resistance patterns

1985 • 45 citations

Uptake and retention of morpholinyl anthracyclines by adriamycin-sensitive and-resistant P388 cells

1986 • 41 citations

Karnofsky memorial lecture. The oncologic end game.

1986 • 35 citations

The in vitro effects and cross-resistance patterns of some novel anthracyclines

1986 • 33 citations

Identification of anthracycline analogues with enhanced cytotoxicity and lack of cross-resistance to adriamycin using a series of mammalian cell lines in vitro

1985 • 27 citations

9-Alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures

1986 • 26 citations

Circumvention of drug resistance in human non-small cell lung cancer in vitro by verapamil

1987 • 24 citations

Selective interactions of verapamil with anthraquinones in adriamycin-sensitive and-resistant murine and human tumour cell lines in vitro

1987 • 8 citations

Cross-resistance of menogaril and mitoxantrone in a subline of P388 leukemia resistant to doxorubicin.

1987 • 6 citations