Vulval development in Caenorhabditis elegans

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells

1992 • 452 citations

The gene lin-3 encodes an inductive signal for vulval development in C. elegans

1992 • 392 citations

lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans

1994 • 385 citations

KSR, a novel protein kinase required for RAS signal transduction

1995 • 335 citations

A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans

1987 • 333 citations

The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction

1995 • 312 citations

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1995 • 306 citations

Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cbl

1995 • 298 citations

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

1993 • 276 citations

LET-23 Receptor Localization by the Cell Junction Protein LIN-7 during C. elegans Vulval Induction

1996 • 268 citations

Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila

1994 • 260 citations

The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.

1989 • 259 citations

Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision

1994 • 254 citations

The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins.

1994 • 254 citations

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

1991 • 246 citations

lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H)

1996 • 232 citations

The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.

1994 • 228 citations

Lateral inhibition during vulval induction in Caenorhabditis elegans

1988 • 218 citations

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.

1994 • 212 citations

The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins.

1996 • 204 citations

Different Levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates

1995 • 200 citations

Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis

1990 • 198 citations

lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development.

1993 • 167 citations

The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.

1995 • 165 citations

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.

1994 • 158 citations

sli-1, a negative regulator of let-23-mediated signaling in C. elegans.

1995 • 149 citations

Sequential signalling during Caenorhabditis elegans vulval induction

1995 • 130 citations

sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.

1995 • 130 citations

unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein.

1994 • 126 citations

Tight junctions, membrane-associated guanylate kinases and cell signaling

1995 • 112 citations

MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.

1995 • 107 citations

Genetics of signal transduction in invertebrates

1994 • 96 citations

The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.

1995 • 95 citations

Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans

1995 • 88 citations

A Point Mutation in the Extracellular Domain Activates LET-23, the Caenorhabditis elegans Epidermal Growth Factor Receptor Homolog

1996 • 86 citations

Signal transduction during C. elegans vulval induction

1991 • 75 citations

The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates.

1990 • 71 citations

lin-25, a gene required for vulval induction in Caenorhabditis elegans.

1995 • 61 citations

The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.

1993 • 60 citations

Spatial and temporal patterns of lin-12 expression during C. elegans hermaphrodite development.

1995 • 52 citations

Mosaic Analysis Using a ncl-1 (+) Extrachromosomal Array Reveals That lin-31 Acts in the Pn.p Cells During Caenorhabditis elegans Vulval Development

1996 • 35 citations