Cumulative effect of double-site mutations of human epidermal growth factor on receptor binding.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Epidermal growth factor.

1990 • 1,645 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

The solution structure of human epidermal growth factor

1987 • 322 citations

Solution structure of murine epidermal growth factor: determination of the polypeptide backbone chain-fold by nuclear magnetic resonance and distance geometry.

1987 • 153 citations

Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling.

1988 • 119 citations

Conformation and unfolding thermodynamics of epidermal growth factor and derivatives

1976 • 98 citations

Cloning of authentic human epidermal growth factor as a bacterial secretory protein and its initial structure-function analysis by site-directed mutagenesis.

1988 • 71 citations

Human epidermal growth factor

1990 • 63 citations

The secreted form of the epidermal growth factor receptor. Characterization and crystallization of the receptor-ligand complex.

1990 • 59 citations

Tertiary Structure of Mouse Epidermal Growth Factor Determined by Two-Dimensional 1H NMR

1988 • 53 citations

Structure‐function analysis of epidermal growth factor: site directed mutagenesis and nuclear magnetic resonance

1990 • 53 citations

Critical functional requirement for the guanidinium group of the arginine 41 side chain of human epidermal growth factor as revealed by mutagenic inactivation and chemical reactivation.

1992 • 52 citations

Purification of the epidermal growth factor receptor by tyrosine-Sepharose affinity chromatography

1985 • 50 citations

Structure-function studies of murine epidermal growth factor: expression and site-directed mutagenesis of epidermal growth factor gene

1988 • 46 citations

Biochemical properties of site-directed mutants of human epidermal growth factor: the importance of solvent-exposed hydrophobic residues of the amino-terminal domain in receptor binding

1990 • 44 citations

Human epidermal growth factor receptor residue covalently cross-linked to epidermal growth factor.

1990 • 43 citations

Mutational analysis of leucine 47 in human epidermal growth factor

1991 • 42 citations

Structure-function relationships in human epidermal growth factor studied by site-directed mutagenesis and proton NMR

1991 • 39 citations

Conformational characterization of a single-site mutant of murine epidermal growth factor (EGF) by 1H NMR provides evidence that leucine-47 is involved in the interactions with the EGF receptor.

1989 • 35 citations

Analogs of human epidermal growth factor which partially inhibit the growth factor-dependent protein-tyrosine kinase activity of the epidermal growth factor receptor

1990 • 34 citations

A site-directed mutagenesis study on the role of isoleucine-23 of human epidermal growth factor in the receptor binding

1992 • 24 citations

Evaluation of the role of electrostatic residues in human epidermal growth factor by site‐directed mutagenesis and chemical modification

1992 • 22 citations