p185^HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines

1979 • 1,885 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

1986 • 1,659 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.

1987 • 1,345 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.

1983 • 792 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Selected methods in cellular immunology

1980 • 747 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

Immunoglobulin producing hybrid cell lines

1980 • 620 citations

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

1987 • 619 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431.

1978 • 578 citations

The neu Gene: an erb B-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor

1985 • 513 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors.

1983 • 456 citations

Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase

1979 • 411 citations

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies

1985 • 408 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.

1987 • 335 citations

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line.

1986 • 329 citations

Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue.

1988 • 251 citations

Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen.

1986 • 231 citations

Molecular analysis of signal transduction by growth factors

1988 • 224 citations

Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.

1987 • 214 citations

A v-erbB-related protooncogene, c-erb-B-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma

1985 • 195 citations

Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.

1987 • 192 citations

Monoclonal antibodies specific for the neu oncogene product directly mediate anti-tumor effects in vivo.

1988 • 155 citations

Identity of some human bladder cancer cell lines

1983 • 142 citations

Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor alpha in NIH 3T3 cells.

1988 • 133 citations

Monoclonal antibodies reactive with distinct domains of the neu oncogene-encoded p185 molecule exert synergistic anti-tumor effects in vivo.

1988 • 127 citations

Molecular mechanisms in tumor-cell killing by activated macrophages

1983 • 127 citations

Do Macrophages Destroy Nascent Tumors?<xref ref-type="fn" rid="FN5">5</xref>

1979 • 119 citations

Effects of growth factors on the antiproliferative activity of tumor necrosis factors.

1987 • 96 citations

Production of functional human T-T hybridomas in selection medium lacking aminopterin and thymidine.

1982 • 88 citations

Intracellular transport and secretion of hepatitis B surface antigen in mammalian cells

1984 • 81 citations

Selection of macrophage-resistant progressor tumor variants by the normal host. Requirement for concomitant T cell-mediated immunity.

1983 • 51 citations

A clonal derivative of tunicamycin‐resistant Chinese hamster ovary cells with increased N‐acetylglucosamine‐phosphate transferase activity has altered asparagine‐linked glycosylation

1987 • 29 citations

[6] Derivation and assay of biological effects of monoclonal antibodies to epidermal growth factor receptors

1987 • 21 citations

Epidermal growth factor receptor tyrosine kinase phosphorylation of glucose-6-phosphate dehydrogenase in vitro

1987 • 16 citations