Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16INK4a and Cdk2/Cyclin E complex activation

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Apoptosis by Death Factor

1997 • 5,038 citations

The Fas Death Factor

1995 • 4,070 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

Control of apoptosis and mitotic spindle checkpoint by survivin

1998 • 1,881 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

1998 • 1,243 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

1998 • 985 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts

1999 • 784 citations

Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer.

1998 • 720 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.

1996 • 637 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Control of Programmed Cell Death by the Baculovirus Genes p35 and iap

1994 • 517 citations

Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation.

1998 • 512 citations

Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas.

1998 • 473 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Induction of the TRPM-2 gene in cells undergoing programmed death.

1989 • 466 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

Induction of Apoptosis and Inhibition of Cell Proliferation bysurvivin Gene Targeting

1998 • 413 citations

Resistance to Fas-mediated apoptosis: activation of Caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP

1998 • 355 citations

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.

1997 • 344 citations

Survivin promotes cell proliferation in human hepatocellular carcinoma

2000 • 329 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death

2000 • 233 citations

Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.

1995 • 222 citations

Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver

1998 • 195 citations

Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors

1999 • 179 citations

Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21

1999 • 157 citations

Tumor Suppressor p16INK4A: Determination of Solution Structure and Analyses of Its Interaction with Cyclin-Dependent Kinase 4

1998 • 157 citations

Mitochondrial Regulation of Cell Death: Mitochondria Are Essential for Procaspase 3-p21 Complex Formation To Resist Fas-Mediated Cell Death

1999 • 133 citations

Regulation of CDK4 activity by a novel CDK4-binding protein, p34SEI-1

1999 • 104 citations

Apoptosis regulated by a death factor and its receptor: Fas ligand and Fas

1994 • 80 citations

Involvement of Fas in regression of vaginal epithelia after ovariectomy and during an estrous cycle.

1996 • 72 citations