Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34+ cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

Control of apoptosis and mitotic spindle checkpoint by survivin

1998 • 1,881 citations

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1997 • 1,316 citations

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

1998 • 1,243 citations

Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin

1989 • 833 citations

Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer.

1998 • 720 citations

Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway

2000 • 633 citations

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

1999 • 613 citations

Expression of survivin and its relationship to loss of apoptosis in breast carcinomas

2000 • 561 citations

Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation.

1998 • 512 citations

Isolation of a Highly Quiescent Subpopulation of Primitive Leukemic Cells in Chronic Myeloid Leukemia

1999 • 508 citations

A Novel Anti-Apoptosis Gene: Re-expression of Survivin Messenger RNA as a Prognosis Marker in Non–Small-Cell Lung Cancers

1999 • 498 citations

A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy.

2000 • 491 citations

Induction of Apoptosis and Inhibition of Cell Proliferation bysurvivin Gene Targeting

1998 • 413 citations

High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma

2000 • 392 citations

Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma

1999 • 371 citations

Prognostic significance of survivin expression in diffuse large B-cell lymphomas

2000 • 368 citations

Control of Apoptosis during Angiogenesis by Survivin Expression in Endothelial Cells

2000 • 347 citations

Marked Induction of the IAP Family Antiapoptotic Proteins Survivin and XIAP by VEGF in Vascular Endothelial Cells

1999 • 342 citations

Survivin promotes cell proliferation in human hepatocellular carcinoma

2000 • 329 citations

Expression of the antiapoptosis gene, Survivin, predicts death from recurrent colorectal carcinoma

2000 • 327 citations

Transcriptional analysis of human survivin gene expression

1999 • 290 citations

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

1999 • 251 citations

Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death

2000 • 233 citations

Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth

2000 • 205 citations

Cytokine-regulated expression of survivinin myeloid leukemia

2001 • 204 citations

The cancer antiapoptosis mouse survivin gene: characterization of locus and transcriptional requirements of basal and cell cycle-dependent expression.

1999 • 202 citations

Functional Heterogeneity of Human CD34+ Cells Isolated in Subcompartments of the G0 /G1 Phase of the Cell Cycle

1997 • 199 citations

Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16INK4a and Cdk2/Cyclin E complex activation

2000 • 196 citations

The Unexpected G0/G1 Cell Cycle Status of Mobilized Hematopoietic Stem Cells From Peripheral Blood

1997 • 191 citations

Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions

2000 • 174 citations

Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line.

1999 • 167 citations

Transcriptional analysis of human survivin gene expression

1999 • 164 citations

Expression and prognostic significance of survivin in de novo acute myeloid leukaemia

2000 • 157 citations

Novel anticancer drug discovery

1999 • 150 citations

Expression and activation of caspase-3/CPP32 in CD34+ cord blood cells is linked to apoptosis after growth factor withdrawal

2000 • 34 citations

Transcriptional and ERK1/2-Dependent Synergistic Upregulation of p21cip1/waf1 Associated with Steel Factor Synergy in MO7e

2001 • 23 citations