Crystal structure of a thermostable Bacillus DNA polymerase l large fragment at 2.1 Å resolution

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

A procedure for the isolation of deoxyribonucleic acid from micro-organisms

1961 • 11,554 citations

Solvent content of protein crystals

1968 • 7,954 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Dominant forces in protein folding

1990 • 3,682 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

The ribosomal database project.

1993 • 1,574 citations

λ ZAP: a bacteriophage λ expression vector within vivoexcision properties

1988 • 1,394 citations

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

1993 • 1,097 citations

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

1991 • 1,059 citations

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1985 • 855 citations

Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding.

1987 • 738 citations

Electrostatic Effects in Proteins

1978 • 734 citations

An attempt to unify the structure of polymerases

1990 • 640 citations

High-fidelity amplification using a thermostable DNA polymerase isolated from Pyrococcus furiosus

1991 • 569 citations

Structure of a Hyperthermophilic Tungstopterin Enzyme, Aldehyde Ferredoxin Oxidoreductase

1995 • 534 citations

Ribbon models of macromolecules

1987 • 519 citations

Thermal stability and protein structure

1979 • 518 citations

High resolution structures of HIV-1 RT from four RT–inhibitor complexes

1995 • 498 citations

Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

1991 • 495 citations

Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA

1993 • 473 citations

Stereochemical basis of heat stability in bacterial ferredoxins and in haemoglobin A2

1975 • 420 citations

The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures

1995 • 409 citations

Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7.

1987 • 399 citations

[39] Unified approach to alignment and phylogenies

1990 • 398 citations

Isolation, Characterization, and Expression in Escherichia coli of the DNA Polymerase Gene from Thermus aquaticus

1989 • 370 citations

The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1.

1995 • 368 citations

Crystal structure of bacteriophage T7 RNA polymerase at 3.3 Å resolution

1993 • 358 citations

Crystal structure of Thermus aquaticus DNA polymerase

1995 • 355 citations

Kinetic mechanism of DNA polymerase I (Klenow)

1987 • 352 citations

A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides.

1995 • 348 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

Selective Elimination of the Exonuclease Activity of the Deoxyribonucleic Acid Polymerase from Escherichia coli B by Limited Proteolysis

1970 • 326 citations

MUTATIONAL EFFECTS ON PROTEIN STABILITY

1989 • 311 citations

Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms

1996 • 283 citations

The 3′-5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.

1991 • 279 citations

Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli.

1990 • 261 citations

[31] PHASES-95: A program package for processing and analyzing diffraction data from macromolecules

1997 • 255 citations

2.0 å structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability

1995 • 224 citations

The Crystal Structure of Holo-glyceraldehyde-3-phosphate Dehydrogenase from the Hyperthermophilic BacteriumThermotoga maritimaat 2.5 Å Resolution

1995 • 218 citations

Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution

1995 • 206 citations

Biologic Synthesis of Deoxyribonucleic Acid

1960 • 204 citations

Characterization of a DNA polymerase from the hyperthermophile archaea Thermococcus litoralis. Vent DNA polymerase, steady state kinetics, thermal stability, processivity, strand displacement, and exonuclease activities.

1993 • 199 citations

Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli.

1992 • 194 citations

X‐ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium pyrococcus furiosus

1992 • 190 citations

Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate

1993 • 175 citations

The crystal structure of citrate synthase from the thermophilic Archaeon, Thermoplasma acidophilum

1994 • 172 citations

Nucleotide sequence of the Escherichia coli polA gene and primary structure of DNA polymerase I.

1982 • 169 citations

Crystal structure of the large fragment of Thermus aquaticus DNA polymerase I at 2.5-A resolution: structural basis for thermostability.

1995 • 166 citations

Insights into DNA Polymerization Mechanisms from Structure and Function Analysis of HIV-1 Reverse Transcriptase

1995 • 164 citations

Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase

1995 • 149 citations

Rate-limiting steps in the DNA polymerase I reaction pathway

1985 • 133 citations

Mutational Analysis of the Fingers and Palm Subdomains of Human Immunodeficiency Virus Type-1 (HIV-1) Reverse Transcriptase

1994 • 82 citations

How to make my blood boil

1995 • 73 citations

Role of proline residues in human lysozyme stability: a scanning calorimetric study combined with x-ray structure analysis of proline mutants

1992 • 71 citations

Evidence for strained interactions between side-chains and the polypeptide backbone

1994 • 68 citations

E. coli DNA polymerase I as a reverse transcriptase.

1993 • 67 citations

Cloning of the DNA Polymerase Gene of Bacillus caldotenax and Characterization of the Gene Product1

1993 • 54 citations

Identification of two genes immediately downstream from the polA gene of Escherichia coli

1982 • 39 citations

The Thumbs's Knuckle

1994 • 38 citations

Purification and properties of deoxyribonucleic acid polymerase from Bacillus stearothermophilus

1981 • 33 citations

Cloning and complete sequence of the DNA polymerase-encoding gene (BstpolI) and characterisation of the Klenow-like fragment from Bacillus stearothermophilus

1995 • 24 citations

Rapid filter assay for the detection of DNA polymerase activity: direct identification of the gene for the DNA polymerase from Thermus aquaticus

1991 • 14 citations