High resolution structures of HIV-1 RT from four RT–inhibitor complexes

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

1993 • 1,097 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

1990 • 749 citations

Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

1990 • 740 citations

Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy

1994 • 584 citations

Crystal Structure of the Ribonuclease H Domain of HIV-1 Reverse Transcriptase

1991 • 566 citations

Slow-cooling protocols for crystallographic refinement by simulated annealing

1990 • 530 citations

Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 Å

1979 • 444 citations

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

1995 • 435 citations

Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture.

1991 • 398 citations

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

1991 • 366 citations

Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.

1994 • 329 citations

Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative

1989 • 288 citations

X-ray diffraction data collection system for modern protein crystallography with a Weissenberg camera and an imaging plate using synchrotron radiation

1991 • 230 citations

HIV resistance to reverse transcriptase inhibitors

1994 • 225 citations

Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones

1991 • 208 citations

Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

1993 • 189 citations

A novel, dipyridodiazepinone inhibitor of HIV-1 reverse transcriptase acts through a nonsubstrate binding site

1991 • 180 citations

An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.

1991 • 166 citations

A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors.

1993 • 163 citations

Interactions Between Drug Resistance Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase

1994 • 158 citations

HIV-1-Specific Reverse Transcriptase Inhibitors Show Differential Activity against HIV-1 Mutant Strains Containing Different Amino Acid Substitutions in the Reverse Transcriptase

1993 • 152 citations

Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors

1993 • 110 citations

Functional analysis of HIV-1 reverse transcriptase amino acids involved in resistance to multiple nonnucleoside inhibitors.

1992 • 107 citations

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy

1993 • 107 citations

Auto-indexing of oscillation images

1990 • 80 citations

Viral resistance to the thiazolo-iso-indolinones, a new class of nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase

1993 • 63 citations

Crystals of HIV-1 Reverse Transcriptase Diffracting to 2·2 Å Resolution

1994 • 61 citations

Modulation of HIV-1 reverse transcriptase function in “selectively deleted” p66/p51 heterodimers.

1994 • 58 citations

Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants.

1994 • 49 citations

Characterization of HIV-1 Strains Isolated from Patients Treated with TIBO R82913

1994 • 46 citations

2.2 å resolution structure of the amino-terminal half of HIV-1 reverse transcriptase (fingers and palm subdomains)

1994 • 46 citations

Selective and synergistic inhibition of human immunodeficiency virus type 1 reverse transcriptase by a non-nucleoside inhibitor, MKC-442.

1993 • 45 citations

Allosteric inhibition of human immunodeficiency virus type 1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione compounds.

1992 • 22 citations

Weissenberg data collection for macromolecular crystallography

1993 • 12 citations

The growth and characterization of crystals of human immunodeficiency virus (HIV) reverse transcriptase

1993 • 7 citations