High-fidelity amplification using a thermostable DNA polymerase isolated from Pyrococcus furiosus

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction

1986 • 3,400 citations

Pyrococcus furiosus sp. nov. represents a novel genus of marine heterotrophic archaebacteria growing optimally at 100�C

1986 • 912 citations

Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase

1988 • 814 citations

Fidelity of DNA polymerases in DNA amplification.

1989 • 487 citations

Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice.

1991 • 473 citations

A conserved 3′→5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases

1989 • 433 citations

High fidelity DNA synthesis by theThermus aquaticusDNA polymerase

1990 • 393 citations

Studies on the Biochemical Basis of Spontaneous Mutation

1972 • 340 citations

Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification.

1990 • 306 citations

Mechanisms of spontaneous mutagenesis: An analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene

1986 • 305 citations

Exonuclease VII of Escherichia coli

1974 • 181 citations

Deoxyribonucleic Acid Polymerase of Bacteriophage T7

1971 • 132 citations

The metabolism of hydrogen by extremely thermophilic, sulfur-dependent bacteria

1990 • 131 citations

Contribution of 3′ → 5′ exonuclease activity of DNA polymerase III holoenzyme from Escherichia coli to specificity

1983 • 88 citations

Missense mutation in the lacI gene of Escherichia coli

1988 • 87 citations

The effect of replication errors on the mismatch analysis of PCR-amplified DNA

1990 • 51 citations

Specificity of proofreading by the 3‘—-5‘ exonuclease of the DNA polymerase-primase of Drosophila melanogaster.

1988 • 42 citations

On the fidelity of DNA synthesis. Pyrophosphate-induced misincorporation allows detection of two proofreading mechanisms.

1986 • 26 citations

Specificity and efficiency of editing of mismatches involved in the formation of base-substitution mutations by the 3'----5' exonuclease activity of phage T4 DNA polymerase.

1987 • 23 citations

On the fidelity of DNA synthesis: Effects of steroids and intercalating agents

1980 • 10 citations