Crystal structure of bacteriophage T7 RNA polymerase at 3.3 Å resolution

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

Complete nucleotide sequence of bacteriophage T7 DNA and the locations of T7 genetic elements

1983 • 1,316 citations

Identification of four conserved motifs among the RNA-dependent polymerase encoding elements.

1989 • 1,195 citations

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

1993 • 1,097 citations

RNA POLYMERASE II

1991 • 729 citations

Cloning and expression of the gene for bacteriophage T7 RNA polymerase.

1984 • 665 citations

An attempt to unify the structure of polymerases

1990 • 640 citations

New RNA Polymerase from Escherichia coli infected with Bacteriophage T7

1970 • 534 citations

Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA

1993 • 473 citations

Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7

1987 • 418 citations

Cycling of ribonucleic acid polymerase to produce oligonucleotides during initiation in vitro at the lac UV5 promoter

1980 • 293 citations

Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli.

1990 • 261 citations

Processivity in early stages of transcription by T7 RNA polymerase

1988 • 256 citations

Bacteriophage SP6-specific RNA polymerase. I. Isolation and characterization of the enzyme.

1982 • 233 citations

RNA chain initiation by Escherichia coli RNA polymerase. Structural transitions of the enzyme in early ternary complexes

1989 • 225 citations

Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli.

1992 • 194 citations

Three-dimensional structure of Escherichia coli RNA polymerase holoenzyme determined by electron crystallography

1989 • 189 citations

Three-dimensional structure of yeast RNA polymerase II at 16 Å resolution

1991 • 161 citations

Interactions of the RNA polymerase of bacteriophage T7 with its promoter during binding and initiation of transcription.

1986 • 160 citations

Targeting bacteriophage T7 RNA polymerase to the mammalian cell nucleus

1988 • 109 citations

Mutations in T7 RNA polymerase that support the proposal for a common polymerase active site structure.

1992 • 103 citations

Processivity of proteolytically modified forms of T7 RNA polymerase

1988 • 99 citations

Interaction of T7 RNA polymerase with DNA in an elongation complex arrested at a specific psoralen adduct site.

1988 • 92 citations

Model for the mechanism of bacteriophage T7 RNAP transcription initiation and termination

1992 • 90 citations

A domain of the klenow fragment of Escherichia coli DNA polymerase I has polymerase but no exonuclease activity

1986 • 90 citations

Four T7 RNA polymerase promoters contain an identical 23 bp sequence

1979 • 86 citations

The use of glycerol in crystallization of T7 RNA polymerase: Implications for the use of cosolvents in crystallizing flexible proteins

1990 • 85 citations

Book review

1989 • 79 citations

Discrimination between bacteriophage T3 and T7 promoters by the T3 and T7 RNA polymerases depends primarily upon a three base-pair region located 10 to 12 base-pairs upstream from the start site

1990 • 78 citations

Identification and amino acid sequence of the deoxynucleoside triphosphate binding site in Escherichia coli DNA polymerase I

1987 • 73 citations

Asp537, Asp812 are essential and Lys631, His811 are catalytically significant in bacteriophage T7 RNA polymerase activity

1992 • 72 citations

Point mutations which drastically affect the polymerization activity of encephalomyocarditis virus RNA-dependent RNA polymerase correspond to the active site of Escherichia coli DNA polymerase I.

1992 • 68 citations

E. coli DNA polymerase I as a reverse transcriptase.

1993 • 67 citations

Nucleotide sequence and expression of the cloned gene of bacteriphage SP6 RNA polymerase

1987 • 67 citations

Transcription termination by bacteriophage T7 RNA polymerase at rho-independent terminators.

1990 • 66 citations

Substrate Binding in Human Immunodeficiency Virus Reverse Transcriptase

1989 • 66 citations

Isolation and characterization of mutant bacteriophage T7 RNA polymerases

1992 • 63 citations

Photoaffinity labeling of the Klenow fragment with 8-azido-dATP.

1990 • 58 citations

Specific binding of monomeric bacteriophage T3 and T7 RNA polymerases to their respective cognate promoters requires the initiating ribonucleoside triphosphate (GTP)

1986 • 56 citations

Promoter melting by T7 ribonucleic acid polymerase as detected by single-stranded endonuclease digestion

1980 • 43 citations

Structure and function of nucleic acids and proteins

1992 • 41 citations

Characterization of bacteriophage T7 RNA polymerase by linker insertion mutagenesis

1992 • 39 citations

Identification of a region of the bacteriophage T3 and T7 RNA polymerases that determines promoter specificity

1990 • 35 citations

Affinity labeling of Escherichia coli DNA polymerase I by 5'-fluorosulfonylbenzoyladenosine. Identification of the domain essential for polymerization and Arg-682 as the site of reactivity.

1988 • 32 citations

The promoter of the glucoamylase-encoding gene of Aspergillus niger functions in Ustilago maydis

1990 • 30 citations

Studies of the ribonucleic acid polymerase from Escherichia coli. V. Studies of its complexes with polyribonucleotides.

1969 • 30 citations

Studies of the Ribonucleic Acid Polymerase from Escherichia coli

1969 • 26 citations

Single crystals of bacteriophage T7 RNA polymerase

1989 • 24 citations

Preparation of crystals of T7 RNA polymerase suitable for high-resolution X-ray structure analysis

1991 • 15 citations

Template primer-dependent binding of 5'-fluorosulfonyl-benzoyldeoxyadenosine by Escherichia coli DNA polymerase I. Identification of arginine 682 as the binding site and its implication in catalysis.

1990 • 14 citations

Sequences of three class II promoters for the bacteriophage T7 RNA polymerase

1981 • 11 citations