The 3′-5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

1991 • 1,059 citations

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1985 • 855 citations

A conserved 3′→5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases

1989 • 433 citations

Active-site zinc ligands and activated H2O of zinc enzymes.

1990 • 432 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli

1989 • 326 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

1988 • 278 citations

Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli.

1990 • 261 citations

Refined structure of alkaline phosphatase from Escherichia coli at 2.8 Å resolution

1985 • 233 citations

The Deoxyribonucleases of Escherichia coli

1964 • 228 citations

Elementary steps in the DNA polymerase I reaction pathway

1983 • 179 citations

Metal ion requirements and other aspects of the reaction catalyzed by M1 RNA, the RNA subunit of ribonuclease P from Escherichia coli

1986 • 177 citations

Nucleotide sequence of the Escherichia coli polA gene and primary structure of DNA polymerase I.

1982 • 169 citations

Construction of a plasmid that overproduces the large proteolytic fragment (Klenow fragment) of DNA polymerase I of Escherichia coli.

1983 • 168 citations

Primary structure of T4 DNA polymerase. Evolutionary relatedness to eucaryotic and other procaryotic DNA polymerases.

1988 • 134 citations

Proofreading by DNA polymerase III of Escherichia coli depends on cooperative interaction of the polymerase and exonuclease subunits.

1987 • 132 citations

DNA substrate structural requirements for the exonuclease and polymerase activities of prokaryotic and phage DNA polymerases

1989 • 101 citations

Protein structure, folding and design

1985 • 93 citations

A domain of the klenow fragment of Escherichia coli DNA polymerase I has polymerase but no exonuclease activity

1986 • 90 citations

Mechanism of selective inhibition of 3' to 5' exonuclease activity of Escherichia coli DNA polymerase I by nucleoside 5'-monophosphates

1978 • 68 citations

Interaction of Escherichia coli DNA polymerase I with azidoDNA and fluorescent DNA probes: identification of protein-DNA contacts

1990 • 60 citations

T5 DNA polymerase: structural--functional relationships to other DNA polymerases.

1989 • 58 citations

Nucleic Acids and Molecular Biology 4

1990 • 50 citations

[1] DNA polymerase I from Escherichia coli

1974 • 47 citations

Stereochemical course of the 3' .fwdarw. 5'-exonuclease activity of DNA polymerase I

1984 • 35 citations