A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

AU-rich elements: characterization and importance in mRNA degradation

1995 • 1,936 citations

Circularization of mRNA by Eukaryotic Translation Initiation Factors

1998 • 940 citations

Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the invivo stability of ARE-containing mRNAs

1998 • 852 citations

RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein

1998 • 738 citations

Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

1999 • 725 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

Cloning and Characterization of HuR, a Ubiquitously Expressed Elav-like Protein

1996 • 652 citations

The mRNA 5′ cap-binding protein eIF4E and control of cell growth

1998 • 651 citations

The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex

1998 • 632 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation

1998 • 560 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro.

1991 • 484 citations

Interference of nonsense mutations with eukaryotic messenger RNA stability.

1979 • 454 citations

Yeast Sm-like proteins function in mRNA decapping and decay

2000 • 434 citations

The yeast exosome and human PM-Scl are related complexes of 3' right-arrow 5' exonucleases

1999 • 433 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

A Sm-like protein complex that participates in mRNA degradation

2000 • 390 citations

Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure.

1993 • 378 citations

Identification of a Regulated Pathway for Nuclear Pre-mRNA Turnover

2000 • 374 citations

The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif

1999 • 365 citations

A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA.

1978 • 365 citations

Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs.

1993 • 356 citations

Yeast mRNA splicing in vitro.

1985 • 337 citations

An essential component of the decapping enzyme required for normal rates of mRNA turnover

1996 • 328 citations

Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element

1999 • 294 citations

Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast.

1995 • 278 citations

mRNA stability in eukaryotes

2000 • 278 citations

An mRNA Stability Complex Functions with Poly(A)-Binding Protein To Stabilize mRNA In Vitro

1999 • 258 citations

Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae

1996 • 246 citations

ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system

1999 • 244 citations

The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes

1998 • 241 citations

Mutations in Translation Initiation Factors Lead to Increased Rates of Deadenylation and Decapping of mRNAs in Saccharomyces cerevisiae

1999 • 240 citations

Multiple portions of poly(A)-binding protein stimulate translation in vivo

2000 • 228 citations

Messenger RNA deadenylylation precedes decapping in mammalian cells

1997 • 205 citations

Yeast Cells Lacking 5'→3' Exoribonuclease 1 Contain mRNA Species That are Poly(A) Deficient and Partially Lack the 5' Cap Structure

1993 • 190 citations

A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif

1988 • 187 citations

Cap-dependent deadenylation of mRNA

2000 • 184 citations

mRNA Decapping in Yeast Requires Dissociation of the Cap Binding Protein, Eukaryotic Translation Initiation Factor 4E

2000 • 184 citations

Interaction between a Poly(A)-Specific Ribonuclease and the 5′ Cap Influences mRNA Deadenylation Rates In Vitro

2000 • 182 citations

Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme

1998 • 160 citations

Mechanisms And Control Of mRNA Decapping in Saccharomyces cerevisiae

2000 • 150 citations

Characterization of cis-Acting Sequences and Decay Intermediates Involved in Nonsense-Mediated mRNA Turnover

1995 • 146 citations

The Two Proteins Pat1p (Mrt1p) and Spb8p Interact In Vivo, Are Required for mRNA Decay, and Are Functionally Linked to Pab1p

2000 • 140 citations

Eukaryotic translation initiation: there are (at least) two sides to every story.

2000 • 138 citations

An A+U-Rich Element RNA-Binding Factor Regulates c-myc mRNA Stability In Vitro

1991 • 121 citations

Hel-N1: an Autoimmune RNA-Binding Protein with Specificity for 3' Uridylate-Rich Untranslated Regions of Growth Factor mRNAs

1993 • 108 citations

The Poly(A) Tail Inhibits the Assembly of a 3′-to-5′ Exonuclease in an In Vitro RNA Stability System

1997 • 107 citations

Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover

1999 • 100 citations

The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex

2000 • 89 citations

Detection in HeLa cell extracts of a 7-methyl guanosine specific enzyme activity that cleaves m7GpppNm

1975 • 89 citations

Purification and characterization of protein synthesis initiation factor eIF-4E from the yeast Saccharomyces cerevisiae

1985 • 85 citations

Anin VitroSystem Using HeLa Cytoplasmic Extracts That Reproduces Regulated mRNA Stability

1999 • 62 citations

Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae.

1996 • 61 citations

Temperature-Sensitive Mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 Genes Result in Defects in mRNA Turnover

1999 • 55 citations

Monitoring mRNA Decapping Activity

1999 • 54 citations

Interrelationships of the Pathways of mRNA Decay and Translation in Eukaryotic Cells

1996 • 50 citations

Mutations in VPS16 and MRT1 Stabilize mRNAs by Activating an Inhibitor of the Decapping Enzyme

1999 • 36 citations

Decapping of stabilized, polyadenylated mRNA in yeastpab1 mutants

1999 • 36 citations

mRNA Decapping in Yeast Requires Dissociation of the Cap Binding Protein, Eukaryotic Translation Initiation Factor 4E

2000 • 17 citations

Decapping of stabilized, polyadenylated mRNA in yeast pab1 mutants

1999 • 8 citations