Characterization of cis-Acting Sequences and Decay Intermediates Involved in Nonsense-Mediated mRNA Turnover

Molecular cloning: A laboratory manual

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Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

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The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

1991 • 487 citations

Interference of nonsense mutations with eukaryotic messenger RNA stability.

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Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae.

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Premature translational termination triggers mRNA decapping

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Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure.

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Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

1989 • 367 citations

Eucaryotic RNA Polymerase Conditional Mutant that Rapidly Ceases mRNA Synthesis

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Translation is required for regulation of histone mRNA degradation

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Gene products that promote mRNA turnover in Saccharomyces cerevisiae.

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mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.

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Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinant.

1992 • 301 citations

The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors.

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REGULATED mRNA STABILITY

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Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.

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Unstable β-globin mRNA in mRNA-deficient β0 thalassemia

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Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.

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Premature translation termination mediates triosephosphate isomerase mRNA degradation.

1988 • 229 citations

Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

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Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse.

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A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons.

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The primary structure of theSaccharomyces cerevisiaegene for 3-phosphogrycerate kinase

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Regulation of mRNA turnover in eukaryotic cells.

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Autoregulated instability of tubulin mRNAS: a novel eukaryotic regulatory mechanism

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Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA.

1990 • 159 citations

Disruption of the gene XRN1, coding for a 5′→3′ exoribonuclease, restricts yeast cell growth

1990 • 152 citations

A single base deletion in the Tfm androgen receptor gene creates a short-lived messenger RNA that directs internal translation initiation.

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Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation.

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Polarity and the Degradation of mRNA

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Translation and a 42-nucleotide segment within the coding region of the mRNA encoded by the MAT alpha 1 gene are involved in promoting rapid mRNA decay in yeast.

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Selective Destabilization of Short-Lived mRNAs with the Granulocyte-Macrophage Colony-Stimulating Factor AU-Rich 3' Noncoding Region Is Mediated by a Cotranslational Mechanism

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Sequences that confer β-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a β-tubulin mRNA

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Fragments of the internal transcribed spacer 1 of pre-rRNA accumulate in Saccharomyces cerevisiae lacking 5'----3' exoribonuclease 1

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Effect of premature termination of translation on mRNA stability depends on the site of ribosome release.

1987 • 127 citations

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

1992 • 124 citations

Determinants and regulation of cytoplasmic mRNA stability in eukaryotic cells

1991 • 119 citations

Nonsense Codons in Human β-Globin mRNA Result in the Production of mRNA Degradation Products

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Nonsense-mediated mRNA Decay in Yeast

1994 • 109 citations

An analysis of the rate of metallothionein mRNA POLY(A)-shortening using RNA blot hybridization

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Mode of Action of Thiolutin, an Inhibitor of Macromolecular Synthesis in Saccharomyces cerevisiae

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FRAMESHIFT SUPPRESSION IN SACCHAROMYCES CEREVISIAE. II. GENETIC PROPERTIES OF GROUP II SUPPRESSORS

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A 5′ → 3′ exoribonuclease of Saccharomyces cerevisiae: Size and novel substrate specificity

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A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae.

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An Intron in the Genes for U3 Small Bucleolar RNAs of the Yeast Saccharomyces cerevisiae

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Messenger RNA turnover in eukaryotic cells.

1988 • 74 citations

Nonsense codons within the Rous sarcoma virus gag gene decrease the stability of unspliced viral RNA.

1991 • 72 citations

Analysis of chimeric mRNAs derived from theSTE3mRNA identifies multiple regions within yeast mRNAs that modulate mRNA decay

1992 • 56 citations

mRNA Turnover in Saccharomyces cerevisiae

1993 • 52 citations

Nonsense suppressors partially revert the decrease of the mRNA level of a nonsense mutant allele in yeast

1990 • 52 citations

What determines the instability of c‐myc proto‐oncogene mRNA?

1992 • 48 citations

Effect of ochre nonsense mutations on yeast URA1 mRNA stability

1984 • 42 citations

A coding region segment is necessary, but not sufficient for rapid decay of the HIS3 mRNA in yeast

1992 • 39 citations

Identification of the cis-acting sequences and trans-acting factors involved in nonsense-mediated mRNA decay

1993 • 32 citations