The Poly(A) Tail Inhibits the Assembly of a 3′-to-5′ Exonuclease in an In Vitro RNA Stability System

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

AU-rich elements: characterization and importance in mRNA degradation

1995 • 1,936 citations

mRNA stability in mammalian cells

1995 • 1,258 citations

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

1992 • 724 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Degradation of mRNA in eukaryotes

1995 • 648 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

5′-Terminal structure and mRNA stability

1977 • 542 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

A common function for mRNA 5' and 3' ends in translation initiation in yeast.

1995 • 374 citations

The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro.

1989 • 373 citations

Poly(A), poly(A) binding protein and the regulation of mRNA stability

1989 • 355 citations

Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system.

1988 • 324 citations

A novel poly(A)-binding protein acts as a specificity factor in the second phase of messenger RNA polyadenylation

1991 • 286 citations

mRNA Decay Mediated by Two Distinct AU-Rich Elements from c-fos and Granulocyte-Macrophage Colony-Stimulating Factor Transcripts: Different Deadenylation Kinetics and Uncoupling from Translation

1995 • 276 citations

The mRNA Poly(A)-Binding Protein: Localization, Abundance, and RNA-Binding Specificity

1994 • 245 citations

Role of Polyadenylation in Nucleocytoplasmic Transport of mRNA

1996 • 229 citations

Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast

1992 • 212 citations

Multiple regulatory steps control histone mRNA concentrations

1988 • 199 citations

The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event.

1995 • 194 citations

A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif

1988 • 187 citations

The protein responsible for the repeating structure of cytoplasmic poly(A)-ribonucleoprotein.

1983 • 175 citations

Erythroid Cell-Specific mRNA Stability Elements in the α2-Globin 39 Nontranslated Region

1995 • 167 citations

The role of poly(A) in the translation and stability of mRNA

1990 • 154 citations

No end yet to messenger RNA 3′ processing!

1995 • 153 citations

Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

1994 • 140 citations

Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping.

1994 • 131 citations

Regulation of proto-oncogene mRNA stability

1992 • 111 citations

Cyclosporin A inhibits growth of autocrine tumour cell lines by destabilizing interleukin-3 mRNA

1994 • 110 citations

A Uridylate Tract Mediates Efficient Heterogeneous Nuclear Ribonucleoprotein C Protein-RNA Cross-Linking and Functionally Substitutes for the Downstream Element of the Polyadenylation Signal

1990 • 107 citations

Properties of a HeLa cell 3' exonuclease specific for degrading poly(A) tails of mammalian mRNA.

1992 • 98 citations

The rate-limiting step in yeast PGK1 mRNA degradation is an endonucleolytic cleavage in the 3'-terminal part of the coding region.

1992 • 96 citations

Modification of the megaprimer method of PCR mutagenesis: improved amplification of the final product.

1993 • 88 citations

The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sites.

1988 • 86 citations

Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay.

1992 • 63 citations

Purification of a human polyribosome-associated 3‘ to 5‘ exoribonuclease.

1994 • 57 citations

The polyribosomal protein bound to the 3' end of histone mRNA can function in histone pre-mRNA processing.

1995 • 55 citations

An RNA-binding protein specifically interacts with a functionally important domain of the downstream element of the simian virus 40 late polyadenylation signal.

1991 • 42 citations

Deadenylation and turnover of interferon-beta mRNA.

1991 • 27 citations

mRNA Decay in Cell-Free Systems

1993 • 12 citations