Chemokine receptors: signposts to brain development and disease

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

2003 • 7,170 citations

Seven-transmembrane receptors

2002 • 2,571 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

The Biology of Chemokines and their Receptors

2000 • 2,416 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease

1999 • 2,174 citations

International union of pharmacology. XXII. Nomenclature for chemokine receptors.

2000 • 1,771 citations

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1998 • 1,687 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

Chemokines and disease

2001 • 1,371 citations

Pathways to neuronal injury and apoptosis in HIV-associated dementia

2001 • 1,190 citations

CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity

2001 • 1,024 citations

Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods

1990 • 805 citations

Chemokine receptors: multifaceted therapeutic targets

2002 • 738 citations

Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity

1998 • 697 citations

The Chemokine Receptor CXCR4 Is Required for the Retention of B Lineage and Granulocytic Precursors within the Bone Marrow Microenvironment

1999 • 691 citations

Central nervous system damage produced by expression of the HIV-1 coat protein gpl20 in transgenic mice

1994 • 678 citations

Guidance of Primordial Germ Cell Migration by the Chemokine SDF-1

2002 • 672 citations

Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis

1999 • 513 citations

Neurogenesis in Adult Mammals: Some Progress and Problems

2002 • 509 citations

Embryonic Expression and Function of the Chemokine SDF-1 and Its Receptor, CXCR4

1999 • 476 citations

Chemokines and Glycoprotein120 Produce Pain Hypersensitivity by Directly Exciting Primary Nociceptive Neurons

2001 • 456 citations

Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4

1998 • 419 citations

A Possible Role for CXCR4 and Its Ligand, the CXC Chemokine Stromal Cell-Derived Factor-1, in the Development of Bone Marrow Metastases in Neuroblastoma

2001 • 419 citations

Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor

2002 • 413 citations

Cannabinoids Promote Oligodendrocyte Progenitor Survival: Involvement of Cannabinoid Receptors and Phosphatidylinositol-3 Kinase/Akt Signaling

2002 • 410 citations

Chemokines and Their Receptors in the Central Nervous System

2001 • 402 citations

Mosaic organization of the hippocampal neuroepithelium and the multiple germinal sources of dentate granule cells

1990 • 395 citations

Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5

1997 • 394 citations

The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors

2001 • 393 citations

Expression of chemokine receptors by subsets of neurons in the central nervous system.

1997 • 384 citations

The chemokine SDF1 regulates migration of dentate granule cells

2002 • 383 citations

Ephrin-B Reverse Signaling Is Mediated by a Novel PDZ-RGS Protein and Selectively Inhibits G Protein–Coupled Chemoattraction

2001 • 382 citations

Expression of CX₃CR1 chemokine receptors on neurons and their role in neuronal survival

2000 • 375 citations

A Dual Role for the SDF-1/CXCR4 Chemokine Receptor System in Adult Brain: Isoform-Selective Regulation of SDF-1 Expression Modulates CXCR4-Dependent Neuronal Plasticity and Cerebral Leukocyte Recruitment after Focal Ischemia

2002 • 372 citations

Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma.

2000 • 371 citations

The Chemokine Receptor CXCR2 Controls Positioning of Oligodendrocyte Precursors in Developing Spinal Cord by Arresting Their Migration

2002 • 369 citations

CXCR4 Is a Major Chemokine Receptor on Glioma Cells and Mediates Their Survival

2002 • 369 citations

Slit proteins: key regulators of axon guidance, axonal branching, and cell migration

2000 • 356 citations

International Union of Pharmacology. XXX. Update on Chemokine Receptor Nomenclature

2002 • 346 citations

Characterization of chemokines and their receptors in the central nervous system: physiopathological implications

2002 • 314 citations

A central role for astrocytes in the inflammatory response to β-amyloid; chemokines, cytokines and reactive oxygen species are produced

1999 • 313 citations

PRESYNAPTIC RECEPTORS

1998 • 293 citations

SDF-1α induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells

2001 • 292 citations

B Lymphocyte Chemotaxis Regulated in Association with Microanatomic Localization, Differentiation State, and B Cell Receptor Engagement

1998 • 276 citations

BDNF stimulates migration of cerebellar granule cells

2002 • 271 citations

Macrophage Tropism of Human Immunodeficiency Virus Type 1 Isolates from Brain and Lymphoid Tissues Predicts Neurotropism Independent of Coreceptor Specificity

2001 • 263 citations

Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer’s disease

2000 • 253 citations

Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors

1993 • 244 citations

Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons

2002 • 238 citations

CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons.

1997 • 235 citations

A Chemokine, SDF-1, Reduces the Effectiveness of Multiple Axonal Repellents and Is Required for Normal Axon Pathfinding

2003 • 228 citations

The Chemokine Growth-Regulated Oncogene-α Promotes Spinal Cord Oligodendrocyte Precursor Proliferation

1998 • 227 citations

Fractalkine and fractalkine receptors in human neurons and glial cells

2002 • 226 citations

Arresting developments in heptahelical receptor signaling and regulation

2002 • 225 citations

Ligand-independent Dimerization of CXCR4, a Principal HIV-1 Coreceptor

2003 • 222 citations

Nerve growth cone guidance mediated by G protein–coupled receptors

2002 • 222 citations

Glial and Neuronal Cells Express Functional Chemokine Receptor CXCR4 and Its Natural Ligand Stromal Cell‐Derived Factor 1

1999 • 220 citations

β-Arrestin Differentially Regulates the Chemokine Receptor CXCR4-mediated Signaling and Receptor Internalization, and This Implicates Multiple Interaction Sites between β-Arrestin and CXCR4

2000 • 214 citations

Constitutive Agonist-independent CCR5 Oligomerization and Antibody-mediated Clustering Occurring at Physiological Levels of Receptors

2002 • 209 citations

gp120-Induced Neurotoxicity in Hippocampal Pyramidal Neuron Cultures: Protective Action of TGF-β1

1996 • 204 citations

Activation of Trk Neurotrophin Receptor Signaling by Pituitary Adenylate Cyclase-activating Polypeptides

2002 • 194 citations

Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons

2002 • 193 citations

Neuronal Fractalkine Expression in HIV-1 Encephalitis: Roles for Macrophage Recruitment and Neuroprotection in the Central Nervous System

2000 • 191 citations

G Protein-Coupled Chemokine Receptors Induce Both Survival and Apoptotic Signaling Pathways

2002 • 189 citations

Stromal cell‐derived factor‐1α induces astrocyte proliferation through the activation of extracellular signal‐regulated kinases 1/2 pathway

2001 • 187 citations

PACAP protects cerebellar granule neurons against oxidative stress‐induced apoptosis

2002 • 181 citations

Astrocytes express functional chemokine receptors

2000 • 180 citations

Stromal cell-derived factor 1 is secreted by meningeal cells and acts as chemotactic factor on neuronal stem cells of the cerebellar external granular layer

2002 • 173 citations

Janus kinase 2 is involved in stromal cell–derived factor-1α–induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells

2001 • 173 citations

Immunohistochemical Analysis of CCR2, CCR3, CCR5, and CXCR4 in the Human Brain: Potential Mechanisms for HIV Dementia

2000 • 168 citations

Differential signalling of the chemokine receptor CXCR4 by stromal cell‐derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes

2000 • 159 citations

Chemokines and angiogenesis

2001 • 152 citations

CXCR-4, a chemokine receptor, is overexpressed in and required for proliferation of glioblastoma tumor cells

1998 • 149 citations

CXC chemokines interleukin-8 (IL-8) and growth-related gene product α (GROα) modulate Purkinje neuron activity in mouse cerebellum

1998 • 148 citations

The Chemokine System in Neuroinflammation: An Update

2002 • 147 citations

Presenilin-1 deficiency leads to loss of Cajal–Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

1999 • 136 citations

The chemokine interleukin‐8 acutely reduces Ca²⁺ currents in identified cholinergic septal neurons expressing CXCR1 and CXCR2 receptor mRNAs

2001 • 135 citations

Developmental pattern of expression of the alpha chemokine stromal cell‐derived factor 1 in the rat central nervous system

2001 • 132 citations

Cloning and characterization of SDF‐1γ, a novel SDF‐1 chemokine transcript with developmentally regulated expression in the nervous system

2000 • 130 citations

SDF‐1α‐mediated modulation of synaptic transmission in rat cerebellum

2000 • 123 citations

Expression of ?-chemokines and chemokine receptors in human fetal astrocyte and microglial co-cultures: Potential role of chemokines in the developing CNS

2001 • 120 citations

Pituitary Adenylate Cyclase-Activating Polypeptide and Sonic Hedgehog Interact to Control Cerebellar Granule Precursor Cell Proliferation

2002 • 117 citations

CXC Chemokine Receptor 4 Expression and Function in Human Astroglioma Cells

2001 • 116 citations

Chemokine receptor dimerization: two are better than one

2001 • 115 citations

gp120 Induces Cell Death in Human Neuroblastoma Cells Through the CXCR4 and CCR5 Chemokine Receptors

2000 • 114 citations

Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant.

2000 • 108 citations

Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons.

1995 • 107 citations

GROα/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation—a role in Alzheimer's disease?

2002 • 99 citations

Fas-induced expression of chemokines in human glioma cells: involvement of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase.

2001 • 96 citations

HIV‐1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid

1997 • 90 citations

Elevated Levels of the Chemokine GRO-1 Correlate with Elevated Oligodendrocyte Progenitor Proliferation in theJimpyMutant

2000 • 87 citations

Primary sensory neurons migrate in response to the chemokine RANTES

1998 • 84 citations

Regulation of calcium currents by chemokines and their receptors

2002 • 82 citations

Murine Astrocytes Express a Functional Chemokine Receptor

1997 • 82 citations

Developmental expression of monocyte chemoattractant protein-1 in the human cerebellum and brainstem

1999 • 81 citations

Developmental expression patterns of CCR5 and CXCR4 in the rhesus macaque brain

2002 • 79 citations

Chemokine receptors and mechanisms of cell death in HIV neuropathogenesis.

2000 • 77 citations

Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor

1997 • 75 citations

Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell‐derived factor 1α activation of G_i2 are differentially expressed in vivo

1997 • 75 citations

Modulation of the neurotransmitter release in rat cerebellar neurons by GROβ

1998 • 74 citations

Mouse astrocytes respond to the chemokines MCP-1 and KC, but reverse transcriptase-polymerase chain reaction does not detect mRNA for the KC or new MCP-1 receptor

1996 • 70 citations

Functional expression of CCR2 by human fetal astrocytes

2002 • 69 citations

Interleukin-6 and cAMP Induce Stromal Cell-derived Factor-1 Chemotaxis in Astroglia by Up-regulating CXCR4 Cell Surface Expression

2002 • 69 citations

Development of astroglial cells in the proliferative matrices, the granule cell layer, and the hippocampal fissure of the hamster dentate gyrus

1992 • 66 citations

The chemokine growth-related gene product β protects rat cerebellar granule cells from apoptotic cell death through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors

2000 • 66 citations

Expression of functional chemokine receptors by rat cerebellar neurons

2002 • 64 citations

Stimulation of chemokine CXC receptor 4 induces synaptic depression of evoked parallel fibers inputs onto Purkinje neurons in mouse cerebellum

2002 • 62 citations

Monocyte chemoattractant protein (MCP)-1 is rapidly expressed by sympathetic ganglion neurons following axonal injury

2001 • 61 citations

RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytes

2002 • 61 citations

Characterization and visualization of [125I] stromal cell-derived factor-1α binding to CXCR4 receptors in rat brain and human neuroblastoma cells

2000 • 60 citations

Characterization of aXenopus laevis CXC chemokine receptor 4: implications for hemato-poietic cell development in the vertebrate embryo

2000 • 52 citations

Mammalian Achaete Scute Homolog 2 Is Expressed in the Adult Sciatic Nerve and Regulates the Expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann Cells

2002 • 51 citations

MCP-1 expression in CNS-1 astrocytoma cells: implications for macrophage infiltration into tumors in vivo.

2002 • 51 citations

Chemokine receptors in the brain: their role in HIV infection and pathogenesis

2002 • 51 citations

DEVELOPMENTAL EXPRESSION OF TWO CXC CHEMOKINES, MIP-2 AND KC, AND THEIR RECEPTORS

2001 • 47 citations

HIV‐associated neuropathies: role of HIV‐1, CMV, and other viruses

2001 • 45 citations

gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5

1998 • 45 citations

Developmental changes in the expression of chemokine receptor CCR1 in the rat cerebellum

2003 • 44 citations

Xenopus laevis Stromal Cell-Derived Factor 1: Conservation of Structure and Function During Vertebrate Development

2002 • 43 citations

Exploitation of the HIV‐1 coat glycoprotein, gp120, in neurodegenerative studies in vivo

2001 • 41 citations

The role of chemokines and chemokine receptors in CNS inflammation

2001 • 41 citations

Mixed lineage kinase 3 mediates gp120IIIB‐induced neurotoxicity

2002 • 38 citations

Meningeal cells stimulate and direct the migration of cerebellar external granule cells in vitro.

1998 • 32 citations

Universes in Delicate Balance: Chemokines and the Nervous System

2003 • 29 citations

Chemokine Interactions with Astrocytes

2002 • 4 citations

Chemokines

2002 • 3 citations

Development and Function of the Hemato-lymphopoietic System

2002 • 2 citations