Janus kinase 2 is involved in stromal cell–derived factor-1α–induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1996 • 1,973 citations

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

1999 • 1,714 citations

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

1997 • 1,414 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

Molecular cloning and structure of a pre-B-cell growth-stimulating factor.

1994 • 818 citations

The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

1998 • 642 citations

The α-Chemokine, Stromal Cell-derived Factor-1α, Binds to the Transmembrane G-protein-coupled CXCR-4 Receptor and Activates Multiple Signal Transduction Pathways

1998 • 627 citations

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

1993 • 516 citations

The chemokine SDF‐lα triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway

1999 • 510 citations

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

1994 • 506 citations

Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes.

1994 • 460 citations

Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?

1997 • 381 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

The Jak-Stat pathway in normal and perturbed hematopoiesis

2000 • 302 citations

Role of Adhesion Molecules in the Homing and Mobilization of Murine Hematopoietic Stem and Progenitor Cells

1998 • 298 citations

Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C

2000 • 266 citations

Chemotaxis of primitive hematopoietic cells in response to stromal cell–derived factor-1

2000 • 255 citations

The CXC Chemokine Stromal Cell-Derived Factor Activates a Gi-Coupled Phosphoinositide 3-Kinase in T Lymphocytes

1999 • 253 citations

The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl

1995 • 235 citations

The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2

1999 • 229 citations

The Chemokine Monocyte Chemotactic Protein 1 Triggers Janus Kinase 2 Activation and Tyrosine Phosphorylation of the CCR2B Receptor

1998 • 224 citations

The α-Chemokine Receptor CXCR4 Is Expressed on the Megakaryocytic Lineage From Progenitor to Platelets and Modulates Migration and Adhesion

1998 • 206 citations

Thrombopoietin Signal Transduction in Purified Murine Megakaryocytes

1997 • 199 citations

Growth Hormone and Prolactin Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrate-1, -2, and -3, Their Association with p85 Phosphatidylinositol 3-Kinase (PI3-kinase), and Concomitantly PI3-kinase Activation via JAK2 Kinase

1998 • 182 citations

The Jak-Stat pathway in normal and perturbed hematopoiesis

2000 • 175 citations

Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes

1996 • 167 citations

Granulocyte-Macrophage Colony-stimulating Factor-activated Signaling Pathways in Human Neutrophils

1998 • 165 citations

Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis.

1998 • 162 citations

RANTES and MIP-1α Activate Stats in T Cells

1998 • 155 citations

Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis.

1999 • 155 citations

Cytokines and JAK–STAT Signaling

1999 • 148 citations

Stromal Cell-Derived Factor-1α and Stem Cell Factor/kit Ligand Share Signaling Pathways in Hemopoietic Progenitors: A Potential Mechanism for Cooperative Induction of Chemotaxis

1998 • 137 citations

Expression of the Human Immunodeficiency Virus Type-1 Coreceptors CXCR-4 (fusin, LESTR) and CKR-5 in CD34+ Hematopoietic Progenitor Cells

1997 • 135 citations

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-γ, but not IFN-α, signaling

1999 • 131 citations

Involvement of Phosphatidylinositol 3-Kinase in Stromal Cell-Derived Factor-1α-Induced Lymphocyte Polarization and Chemotaxis

1999 • 122 citations

Adhesion and homing of blood-borne cells in bone marrow microvessels

1999 • 121 citations

Similarities and Differences in RANTES- and (AOP)-RANTES–triggered Signals: Implications for Chemotaxis

1999 • 117 citations

Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation

1998 • 115 citations

Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand

1995 • 114 citations

Stromal Derived Factor-1–Induced Chemokinesis of Cord Blood CD34+ Cells (Long-Term Culture-Initiating Cells) Through Endothelial Cells Is Mediated by E-Selectin

1999 • 107 citations

B Cell Antigen Receptor Engagement Inhibits Stromal Cell–derived Factor (SDF)-1α Chemotaxis and Promotes Protein Kinase C (PKC)-induced Internalization of CXCR4

1999 • 102 citations

Janus Kinases and Focal Adhesion Kinases Play in the 4.1 Band: A Superfamily of Band 4.1 Domains Important for Cell Structure and Signal Transduction

1998 • 95 citations

Increased migration of cord blood-derived CD34+ cells, as compared to bone marrow and mobilized peripheral blood CD34+ cells across uncoated or fibronectin-coated filters

1999 • 94 citations

Relationship between selectin-mediated rolling of hematopoietic stem and progenitor cells and progression in hematopoietic development

2000 • 90 citations

Granulocyte-Macrophage Colony-stimulating Factor-activated Signaling Pathways in Human Neutrophils

1999 • 87 citations

Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

1998 • 75 citations

Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor.

1996 • 71 citations

G-CSF Induces Tyrosine Phosphorylation of the JAK2 Protein in the Human Myeloid G-CSF Responsive and Proliferative Cells, but Not in Mature Neutrophils

1994 • 58 citations

Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways.

1998 • 50 citations

Interleukin (IL)-7 Induces Rapid Activation of Pyk2, Which Is Bound to Janus Kinase 1 and IL-7Rα

2000 • 41 citations

A novel human leukaemic cell line, CTS, has a t(6;11) chromosomal translocation and characteristics of pluripotent stem cells

1996 • 25 citations