Ligand-independent Dimerization of CXCR4, a Principal HIV-1 Coreceptor

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

1996 • 2,735 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

1996 • 2,326 citations

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1996 • 1,973 citations

A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors

1996 • 1,868 citations

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

1996 • 1,678 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

Genotypic and Phenotypic Characterization of HIV-1 Patients with Primary Infection

1993 • 1,258 citations

CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5

1996 • 1,181 citations

GABAB-receptor subtypes assemble into functional heteromeric complexes

1998 • 1,163 citations

Heterodimerization is required for the formation of a functional GABAB receptor

1998 • 1,156 citations

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

1992 • 1,059 citations

GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2

1998 • 1,054 citations

Interaction of membrane proteins and lipids with solubilizing detergents

2000 • 982 citations

X-ray Structure of Bacteriorhodopsin at 2.5 Angstroms from Microcrystals Grown in Lipidic Cubic Phases

1997 • 861 citations

A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation

1996 • 758 citations

Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1

1997 • 724 citations

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1989 • 662 citations

Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1988 • 621 citations

Selective Transmission of Human Immunodeficiency Virus Type-1 Variants from Mothers to Infants

1992 • 598 citations

REPLICATIVE CAPACITY OF HUMAN IMMUNODEFICIENCY VIRUS FROM PATIENTS WITH VARYING SEVERITY OF HIV INFECTION

1986 • 536 citations

Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection

1993 • 474 citations

Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI

1991 • 388 citations

Mechanism of Transdominant Inhibition of CCR5-mediated HIV-1 Infection by ccr5Δ32

1997 • 371 citations

GPCRDB: an information system for G protein-coupled receptors

1998 • 331 citations

Dimeric association and segmental variability in the structure of human CD4

1997 • 266 citations

Genomic sciences and the medicine of tomorrow

1996 • 240 citations

Detergent binding as a measure of hydrophobic surface area of integral membrane proteins.

1993 • 222 citations

Constitutive Agonist-independent CCR5 Oligomerization and Antibody-mediated Clustering Occurring at Physiological Levels of Receptors

2002 • 209 citations

The structure of medicine.

1948 • 200 citations

Conformational Changes in Cell Surface HIV-1 Envelope Glycoproteins Are Triggered by Cooperation between Cell Surface CD4 and Co-receptors

1998 • 178 citations

Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1α, a potent ligand for the HIV-1 “fusin” coreceptor

1998 • 151 citations

Adaptation to persistent growth in the H9 cell line renders a primary isolate of human immunodeficiency virus type 1 sensitive to neutralization by vaccine sera

1995 • 143 citations

HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization

2000 • 138 citations

Dimerization and Domain Swapping in G-Protein-Coupled Receptors A Computational Study

2000 • 137 citations

Dimerization of G-Protein-Coupled Receptors

2001 • 136 citations

Heterologous expression of G-protein-coupled receptors

1996 • 128 citations

Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery

1997 • 126 citations

Oligomerization of Dopamine and Serotonin Receptors

2000 • 113 citations

A biosensor assay for studying ligand-membrane receptor interactions: Binding of antibodies and HIV-1 Env to chemokine receptors

2000 • 109 citations

Paramagnetic proteoliposomes containing a pure, native, and oriented seven-transmembrane segment protein, CCR5

2000 • 108 citations

Dual tropism for macrophages and lymphocytes is a common feature of primary human immunodeficiency virus type 1 and 2 isolates

1994 • 103 citations

Functional rescue of a constitutively desensitized β2AR through receptor dimerization

1998 • 90 citations

Ligand Binding Characteristics of CXCR4 Incorporated into Paramagnetic Proteoliposomes

2001 • 90 citations

Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gp120.

1992 • 79 citations

Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery

1997 • 75 citations

Solution Studies of Recombinant Human Stromal-Cell-Derived Factor-1

2001 • 39 citations