Slit proteins: key regulators of axon guidance, axonal branching, and cell migration

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6

1994 • 1,346 citations

Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance

1999 • 1,155 citations

Slit Is the Midline Repellent for the Robo Receptor in Drosophila

1999 • 930 citations

Roundabout Controls Axon Crossing of the CNS Midline and Defines a Novel Subfamily of Evolutionarily Conserved Guidance Receptors

1998 • 882 citations

RETRACTED: A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion

1999 • 686 citations

Mutations affecting growth cone guidance in drosophila: Genes necessary for guidance toward or away from the midline

1993 • 677 citations

Directional guidance of neuronal migration in the olfactory system by the protein Slit

1999 • 517 citations

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.

1990 • 499 citations

Biochemical Purification of a Mammalian Slit Protein as a Positive Regulator of Sensory Axon Elongation and Branching

1999 • 464 citations

Vertebrate Slit, a Secreted Ligand for the Transmembrane Protein Roundabout, Is a Repellent for Olfactory Bulb Axons

1999 • 444 citations

GROWTH CONE GUIDANCE: First Steps Towards a Deeper Understanding

1999 • 431 citations

Dosage-Sensitive and Complementary Functions of Roundabout and Commissureless Control Axon Crossing of the CNS Midline

1998 • 300 citations

The Mouse SLIT Family: Secreted Ligands for ROBO Expressed in Patterns That Suggest a Role in Morphogenesis and Axon Guidance

1999 • 288 citations

The Conserved Immunoglobulin Superfamily Member SAX-3/Robo Directs Multiple Aspects of Axon Guidance in C. elegans

1998 • 280 citations

Slit2-Mediated Chemorepulsion and Collapse of Developing Forebrain Axons

1999 • 280 citations

commissureless Controls Growth Cone Guidance across the CNS Midline in Drosophila and Encodes a Novel Membrane Protein

1996 • 260 citations

Chemorepulsion of Neuronal Migration by Slit2 in the Developing Mammalian Forebrain

1999 • 250 citations

Cellular and Molecular Guidance of GABAergic Neuronal Migration from an Extracortical Origin to the Neocortex

1999 • 243 citations

Conservation and divergence of axon guidance mechanisms

1999 • 227 citations

Chimeric Axon Guidance Receptors

1999 • 190 citations

Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system

1998 • 174 citations

Identification of High-Molecular-Weight Proteins with Multiple EGF-like Motifs by Motif-Trap Screening

1998 • 172 citations

Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis

1998 • 149 citations

Axon repulsion from the midline of the Drosophila CNS requires slit function

1999 • 132 citations

Regulation of LNS Domain Function by Alternative Splicing: The Structure of the Ligand-Binding Domain of Neurexin Iβ

1999 • 129 citations

Mammalian Homologues of the Drosophila Slit Protein Are Ligands of the Heparan Sulfate Proteoglycan Glypican-1 in Brain

1999 • 124 citations

Cloning and Functional Studies of a Novel Gene Aberrantly Expressed in RB-Deficient Embryos

1999 • 120 citations

Mesectodermal cell fate analysis in Drosophila midline mutants

1994 • 70 citations

Neuronal growth cone collapse triggers lateral extensions along trailing axons

1999 • 69 citations

Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system

1996 • 61 citations

Effects ofroundabouton Growth Cone Dynamics, Filopodial Length, and Growth Cone Morphology at the Midline and throughout the Neuropile

1999 • 39 citations

A target-derived chemoattractant controls the development of the corticopontine projection by a novel mechanism of axon targeting.

1991 • 35 citations

A target-derived chemoattractant controls the development of the corticopontine projection by a novel mechanism of axon targeting

1991 • 30 citations