GROα/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation—a role in Alzheimer's disease?

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Human Chemokines: An Update

1997 • 2,235 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

1998 • 1,118 citations

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

1999 • 999 citations

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 • 997 citations

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

1997 • 923 citations

The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications

2001 • 813 citations

B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5

1998 • 807 citations

Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity

1998 • 697 citations

Chemokine receptors: Gateways to inflammation and infection

1996 • 659 citations

Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5

1993 • 470 citations

Physiological Regulation of G Protein-Linked Signaling

1999 • 449 citations

Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha.

1992 • 402 citations

Expression of chemokine receptors by subsets of neurons in the central nervous system.

1997 • 384 citations

Fractalkine Cleavage from Neuronal Membranes Represents an Acute Event in the Inflammatory Response to Excitotoxic Brain Damage

2000 • 355 citations

Chemokines and receptors in HIV encephalitis

1998 • 315 citations

Expression and biologic characterization of the murine chemokine KC.

1995 • 305 citations

Role of Resident Peritoneal Macrophages and Mast Cells in Chemokine Production and Neutrophil Migration in Acute Inflammation: Evidence for an Inhibitory Loop Involving Endogenous IL-10

1999 • 300 citations

Prevalence of genotypic resistance to nucleoside analogues in antiretroviral-naive and antiretroviral-experienced HIV-infected patients in Spain

1998 • 299 citations

The Endogenous and Cell Cycle-dependent Phosphorylation of tau Protein in Living Cells: Implications for Alzheimer’s Disease

1998 • 296 citations

Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases

1997 • 294 citations

Immunohistochemical Study of the β-Chemokine Receptors CCR3 and CCR5 and Their Ligands in Normal and Alzheimer's Disease Brains

1998 • 277 citations

Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix. Involvement of cAMP signaling pathway.

1995 • 265 citations

Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease

1999 • 263 citations

Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer’s disease

2000 • 253 citations

Upregulation of Interleukin 8 by Oxygen-deprived Cells in Glioblastoma Suggests a Role in Leukocyte Activation, Chemotaxis, and Angiogenesis

1997 • 244 citations

Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors

1993 • 244 citations

CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons.

1997 • 235 citations

Cytokine Regulation of Human Microglial Cell IL-8 Production

1998 • 226 citations

β-Arrestin Differentially Regulates the Chemokine Receptor CXCR4-mediated Signaling and Receptor Internalization, and This Implicates Multiple Interaction Sites between β-Arrestin and CXCR4

2000 • 214 citations

Stress‐Activated Protein Kinase/c‐Jun N‐Terminal Kinase Phosphorylates τ Protein

1997 • 213 citations

Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases.

1995 • 211 citations

INTERLEUKIN-8 AS AN AUTOCRINE GROWTH FACTOR FOR HUMAN COLON CARCINOMA CELLS IN VITRO

2000 • 203 citations

Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons

2000 • 201 citations

Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly.

1993 • 198 citations

cAMP-Dependent Protein Kinase Phosphorylations on Tau in Alzheimer’s Disease

1999 • 193 citations

The endocytic receptor protein LRP also mediates neuronal calcium signaling via N -methyl- <scp>d</scp> -aspartate receptors

2000 • 186 citations

Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells.

1995 • 176 citations

Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK.

1999 • 175 citations

Cutting Edge: Identification of the Orphan Chemokine Receptor GPR-9-6 as CCR9, the Receptor for the Chemokine TECK

1999 • 167 citations

Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages

1994 • 152 citations

The Dynamics of Neuronal Death: A Time-Lapse Study in the Retina

2000 • 147 citations

The chemokine interleukin‐8 acutely reduces Ca²⁺ currents in identified cholinergic septal neurons expressing CXCR1 and CXCR2 receptor mRNAs

2001 • 135 citations

A Kinase to Remember: Dual Roles for MAP Kinase in Long-Term Memory

1997 • 132 citations

Cloning and characterization of SDF‐1γ, a novel SDF‐1 chemokine transcript with developmentally regulated expression in the nervous system

2000 • 130 citations

Neuronal MCP-1 Expression in Response to Remote Nerve Injury

2001 • 127 citations

Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease.

1997 • 127 citations

In situ hybridization analysis of glial fibrillary acidic protein mRNA reveals evidence of biphasic astrocyte activation during acute experimental autoimmune encephalomyelitis.

1996 • 124 citations

The Sodium Channel Blocker and Glutamate Release Inhibitor BW1003C87 and Magnesium Attenuate Regional Cerebral Edema Following Experimental Brain Injury in the Rat

1995 • 120 citations

A comparison of post‐receptor signal transduction events in Jurkat cells transfected with either IL‐8R1 or IL‐8R2 Chemokine mediated activation of p42/p44 MAP‐kinase (ERK‐2)

1995 • 119 citations

Cytokine-induced neutrophil chemoattractant mRNA expressed in cerebral ischemia

1993 • 114 citations

Brain Protein Kinase PK40erk Converts TAU into a PHF-like Form as Found in Alzheimer′s Disease

1993 • 113 citations

Effects of MGSA/GRO alpha on melanocyte transformation.

1991 • 103 citations

Paired helical filament tau in Alzheimer's disease. The kinase connection.

1994 • 102 citations

Expression of the chemokine receptors CXCR1 and CXCR2 in rat oligodendroglial cells

2001 • 95 citations

Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease.

1994 • 94 citations

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites

1993 • 90 citations

Endothelin-1 Induces Production of the Neutrophil Chemotactic Factor Interleukin-8 by Human Brain-Derived Endothelial Cells

1998 • 82 citations

Negative feedback between prostaglandin and alpha- and beta-chemokine synthesis in human microglial cells and astrocytes.

1999 • 75 citations

Cryptococcal Glucuronoxylomannan Induces Interleukin (IL)‐8 Production by Human Microglia but Inhibits Neutrophil Migration toward IL‐8

1998 • 75 citations

Modulation of the neurotransmitter release in rat cerebellar neurons by GROβ

1998 • 74 citations

HIV-1 tat protein induces the production of interleukin-8 by human brain-derived endothelial cells

1999 • 73 citations

Endothelin-1 Induces Production of the Neutrophil Chemotactic Factor Interleukin-8 by Human Brain-Derived Endothelial Cells

1998 • 62 citations

Negative Feedback Between Prostaglandin and α- and β-Chemokine Synthesis in Human Microglial Cells and Astrocytes

1999 • 57 citations

IL-8-induced signal transduction in T lymphocytes involves receptor-mediated activation of phospholipases C and D.

1995 • 56 citations

cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors

1994 • 55 citations

Expression of JE (Monocyte Chemoattractant Protein-1) Is Induced by Sciatic Axotomy in Wild Type Rodents but Not in C57BL/Wld S Mice

1998 • 55 citations

Dying like Flies

1998 • 51 citations

Interleukin-8 Receptors R1 and R2 Activate Mitogen-Activated Protein Kinases and Induce c-fos, Independent of Ras and Raf-1 in Chinese Hamster Ovary Cells

1998 • 50 citations

Interleukin 8 is an autocrine growth factor and a surrogate marker for Kaposi's sarcoma.

2001 • 50 citations

β-Amyloid(25–35) induces the production of interleukin-8 from human monocytes

1995 • 43 citations

Macrophages and Hepatocytic Cells as Chemokine Producers in Murine Listeriosis

1998 • 36 citations

Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431.

1999 • 36 citations

The order of exposure of tau to signal transduction kinases alters the generation of "AD-like" phosphoepitopes.

1999 • 19 citations

Neutrophil-activating polypeptides IL-8 and NAP-2 induce identical signal transduction pathways in the regulation of lysosomal enzyme release.

1991 • 17 citations

[21] Analysis of signal transduction following lymphocyte activation by chemokines

1997 • 9 citations

Inhibition of Adenylyl Cyclase by α Chemokines IL-8 and GRO-α in Chinese Hamster Ovary Cells Expressing R1 and R2 Receptors

1998 • 5 citations

Chemokines in the Central Nervous System and Alzheimer's Disease

2002 • 1 citations