Sphingosine-1-Phosphate in Inhibition of Male Germ Cell Apoptosis in the Human Testis

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

Programmed cell death: alive and well in the new millennium

2001 • 663 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

Molecular mechanisms of male germ cell differentiation

1998 • 429 citations

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2

2000 • 393 citations

Estradiol Acts as a Germ Cell Survival Factor in the Human Testis in Vitro*

2000 • 374 citations

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

1999 • 371 citations

Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction

1997 • 354 citations

Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death

1998 • 345 citations

Inhibition of the Neutral Magnesium-dependent Sphingomyelinase by Glutathione

1997 • 306 citations

The Lipids C2- and C16-Ceramide Form Large Stable Channels

2000 • 302 citations

Sphingosine‐1‐phosphate: signaling inside and out

2000 • 275 citations

Ceramide Induces Cytochrome c Release from Isolated Mitochondria

1999 • 273 citations

Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosisin vivo

1998 • 244 citations

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

2000 • 195 citations

Apoptotic mechanisms in acute renal failure

2000 • 191 citations

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218

1999 • 183 citations

Caspase-3 Gene Knockout Defines Cell Lineage Specificity for Programmed Cell Death Signaling in the Ovary*

2001 • 183 citations

Fas regulates germ cell apoptosis in the human testis in vitro

1999 • 176 citations

Involvement of Sphingosine in Mitochondria-dependent Fas-induced Apoptosis of Type II Jurkat T Cells

2000 • 176 citations

The relevance of spontaneous- and chemically-induced alterations in testicular germ cell apoptosis to toxicology

2000 • 172 citations

Transcriptional CheckpointsDetermining the Fate of Male Germ Cells

1997 • 172 citations

Sphingosine kinase: a mediator of vital cellular functions

2001 • 151 citations

Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells.

2001 • 149 citations

Apoptosis and the liver

2000 • 148 citations

Lactate inhibits germ cell apoptosis in the human testis

2002 • 146 citations

TNFα Down-Regulates the Fas Ligand and Inhibits Germ Cell Apoptosis in the Human Testis

2001 • 125 citations

In vivo control of respiration by cytochrome c oxidase in human cells

2000 • 125 citations

Peroxisome Proliferator-Activated Receptor γ Induces Pancreatic Cancer Cell Apoptosis

2001 • 113 citations

Molecular and cellular mechanisms in spermatogenesis

2000 • 110 citations

Sphingomyelin metabolites in vascular cell signaling and atherogenesis

2000 • 110 citations

The modulation of sperm function by fertilization promoting peptide

1998 • 109 citations

Testosterone Regulates Apoptosis in Adult Human Seminiferous Tubulesin Vitro¹

1997 • 105 citations

Ceramide generation by two distinct pathways in tumor necrosis factor α‐induced cell death

2001 • 105 citations

In-vitro effects of FSH and testosterone withdrawal on caspase activation and DNA fragmentation in different cell types of human seminiferous epithelium

2002 • 100 citations

Testicular and sperm DNA damage after treatment with fludarabine for chronic lymphocytic leukaemia

2000 • 100 citations

Sphingosine 1-Phosphate Triggers Both Apoptotic and Survival Signals for Human Hepatic Myofibroblasts

2002 • 98 citations

Cell Autonomous Apoptosis Defects in Acid Sphingomyelinase Knockout Fibroblasts

2001 • 97 citations

N-Acetyl-<scp>l</scp>-Cysteine Inhibits Apoptosis in Human Male Germ Cellsin Vitro¹

1998 • 92 citations

Ceramide and sphingomyelinases in the regulation of stress responses

1999 • 91 citations

Sphingosine‐1‐phosphate modulates growth and adhesion of ovarian cancer cells

1999 • 87 citations

Identification of living spermatogenic cells of the mouse by transillumination-phase contrast microscopic technique for ?in situ? analyses of DNA polymerase activities

1981 • 86 citations

Nuclear Factor-κB Activation in Human Testicular Apoptosis

2002 • 86 citations

Reproductive Pathology and Sperm Physiology in Acid Sphingomyelinase-Deficient Mice

2002 • 71 citations

Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes

1999 • 67 citations

4 Local control systems within the testis

1992 • 48 citations

Ceramide and apoptosis

1999 • 47 citations

Partial Oxygen Pressure and Mitochondrial Permeability Transition Affect Germ Cell Apoptosis in the Human Testis¹

1999 • 45 citations

Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells

1994 • 42 citations

Induction of Apoptosis by Sphingosine-1-Phosphate in Human Hepatoma Cells Is Associated with Enhanced Expression of bax Gene Product

1996 • 38 citations

The effect of cancer and its therapy upon fertility.

1981 • 14 citations