Apoptotic mechanisms in acute renal failure

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

The Fas Death Factor

1995 • 4,070 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

NF-κB: Ten Years After

1996 • 3,008 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Caspases: killer proteases

1997 • 2,440 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1998 • 1,381 citations

Bcl-2 family proteins

1998 • 1,055 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

The p53 Network

1998 • 731 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.

1994 • 607 citations

Reactive oxygen intermediates as mediators of programmed cell death in plants and animals

1999 • 594 citations

Modulation of life and death by the TNF receptor superfamily

1998 • 543 citations

Apoptosis: an overview

1997 • 501 citations

Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia.

1992 • 445 citations

Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis

1996 • 442 citations

OXIDANT MECHANISMS IN TOXIC ACUTE RENAL FAILURE*

1999 • 429 citations

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

1998 • 421 citations

Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice.

1994 • 414 citations

Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure.

1989 • 400 citations

Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney

1997 • 374 citations

Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells

1998 • 364 citations

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

1997 • 309 citations

Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

1998 • 294 citations

Reactive Oxygen Species and Antioxidants in Signal Transduction and Gene Expression

2009 • 281 citations

Oxidant mechanisms in toxic acute renal failure

1997 • 277 citations

Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure.

1998 • 265 citations

N-acetyl cysteine ameliorates ischemic renal failure

1997 • 219 citations

Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases

1998 • 216 citations

Necrosis and apoptosis in acute renal failure.

1998 • 214 citations

Hepatocyte growth factor accelerates recovery from acute ischemic renal injury in rats

1994 • 208 citations

Role of Reactive Oxygen Intermediates in Activation-induced CD95 (APO-1/Fas) Ligand Expression

1998 • 193 citations

Cell apoptosis and proliferation in experimental chronic obstructive uropathy

1996 • 185 citations

Apoptosis of Renal Cortical Cells in the Hemolytic-Uremic Syndrome: In Vivo and In Vitro Studies

1998 • 183 citations

Induction of apoptosis in ischemia-reperfusion model of mouse kidney

1998 • 175 citations

Thrombotic Thrombocytopenic Purpura and Sporadic Hemolytic-Uremic Syndrome Plasmas Induce Apoptosis in Restricted Lineages of Human Microvascular Endothelial Cells

1997 • 172 citations

Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis

1998 • 170 citations

Anti-apoptotic versus pro-apoptotic signal transduction: Checkpoints and stop signs along the road to death

1998 • 161 citations

The proto-oncogene c-myc and apoptosis

1998 • 160 citations

Thiazide treatment of rats provokes apoptosis in distal tubule cells

1996 • 157 citations

Stimulated kidney tubular epithelial cells express membrane associated and secreted TNFα

1991 • 151 citations

Mediation by Arachidonic Acid Metabolites of the H₂O₂‐Induced Stimulation of Mitogen‐Activated Protein Kinases (Extracellular‐Signal‐Regulated Kinase and c‐Jun NH₂‐Terminal Kinase)

1997 • 149 citations

Partial ATP depletion induces Fas- and caspase-mediated apoptosis in MDCK cells

1999 • 141 citations

APOPTOSIS IN ISCHEMIA/REPERFUSION INJURY OF HUMAN RENAL ALLOGRAFTS1

1998 • 135 citations

Rapid DNA fragmentation from hypoxia along the thick ascending limb of rat kidneys

1995 • 132 citations

Intracellular targets in heme protein-induced renal injury

1998 • 129 citations

Dephosphorylation of Focal Adhesion Kinase (FAK) and Loss of Focal Contacts Precede Caspase-mediated Cleavage of FAK during Apoptosis in Renal Epithelial Cells

1999 • 127 citations

Verotoxins induce apoptosis in human renal tubular epithelium derived cells

1998 • 115 citations

Effect of AT₂receptor blockade on the pathogenesis of renal fibrosis

1999 • 114 citations

Obstructive nephropathy in the neonatal rat is attenuated by epidermal growth factor

1998 • 112 citations

Induction of Apoptosis in Normal Human Renal Tubular Epithelial Cells by Escherichia coli Shiga Toxins 1 and 2

1998 • 112 citations

A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome.

1993 • 107 citations

Expression of bcl-2 and bax in regenerating rat renal tubules following ischemic injury

1997 • 106 citations

Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia

1996 • 104 citations

The Membrane-bound Form of Heparin-binding Epidermal Growth Factor-like Growth Factor Promotes Survival of Cultured Renal Epithelial Cells

1997 • 104 citations

Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells

1996 • 104 citations

Radiocontrast-induced DNA fragmentation of renal tubular cells in vitro: role of hypertonicity

1998 • 103 citations

Activation of a 15-kDa endonuclease in hypoxia/reoxygenation injury without morphologic features of apoptosis.

1995 • 102 citations

Identification and characterization of murine caspase-14, a new member of the caspase family.

1998 • 97 citations

Reactive oxygen intermediate(s) (ROI): Common mediator(s) of poly(ADP‐ribose)polymerase (PARP) cleavage and apoptosis

1996 • 96 citations

Role of superoxide in apoptosis induced by growth factor withdrawal

1998 • 90 citations

Hyperplasia, hypertrophy, and phenotypic alterations in the distal nephron after acute proximal tubular injury in the rat.

1994 • 90 citations

Hepatocyte Growth Factor Protects Renal Epithelial Cells from Apoptotic Cell Death

1998 • 89 citations

APOPTOSIS IN THE HUMAN ALLOGRAFTED KIDNEY

1995 • 89 citations

Altered ceramide and sphingosine expression during the induction phase of ischemic acute renal failure

1997 • 84 citations

Hydrogen peroxide induces nuclear translocation of p53 and apoptosis in cells of oligodendroglia origin

1999 • 84 citations

APOPTOSIS IN THE HUMAN ALLOGRAFTED KIDNEY

1995 • 80 citations

MyD genes in negative growth control

1998 • 77 citations

An evaluation of renal tubular DNA laddering in response to oxygen deprivation and oxidant injury.

1994 • 75 citations

Comparison of the Structural Changes Induced by Doxorubicin and Mitoxantrone in the Heart, Kidney and Intestine and Characterization of the Fe(III)-mitoxantrone Complex

1997 • 74 citations

Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A Rapid Communication

1997 • 70 citations

Hydrogen Peroxide Induces Necrosis, Apoptosis, Oncosis and Apoptotic Oncosis of Mouse Terminal Proximal Straight Tubule Cells

1999 • 67 citations

Altered sphingomyelinase and ceramide expression in the setting of ischemic and nephrotoxic acute renal failure

1998 • 65 citations

Effect of Bcl-2 on oxidant-induced cell death and intracellular Ca²⁺mobilization

1998 • 64 citations

Epidermal growth factor suppresses renal tubular apoptosis following ureteral obstruction

1997 • 64 citations

Role of enhanced ceramide generation in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells

1998 • 63 citations

Expression and function of Fas (CD95) on human renal tubular epithelial cells.

1997 • 63 citations

APOPTOTIC CELL DEATH IN HUMAN CHRONIC RENAL ALLOGRAFT REJECTION

1997 • 61 citations

CADMIUM-INDUCED APOPTOSIS IN THE UROGENITAL ORGANS OF THE MALE RAT AND ITS SUPPRESSION BY CHELATION

1997 • 59 citations

Apoptosis and necrosis during ischaemia in renal tubular cells (LLC-PK1 and MDCK)

1998 • 55 citations

Ceramide accumulation during oxidant renal tubular injury

1998 • 53 citations

Growth factors and apoptosis in acute renal injury

1998 • 52 citations

Ciprofloxacin overdose: Acute renal failure with prominent apoptotic changes

1998 • 52 citations

Inorganic mercury chloride-induced apoptosis in the cultured porcine renal cell line LLC-PK1.

1996 • 50 citations

Effect of recombinant human insulin-like growth factor-1 on the inflammatory response to acute renal injury.

1996 • 50 citations

Iron-induced apoptosis in mouse renal proximal tubules after an injection of a renal carcinogen, iron-nitrilotriacetate

1997 • 49 citations

Increase urinary hepatocyte growth factor excretion in human acute renal failure.

1997 • 47 citations

Protection from cadmium cytotoxicity by N-acetylcysteine in LLC-PK1 cells.

1998 • 46 citations

Clusterin expression and apoptosis in tissue remodeling associated with renal regeneration

1995 • 45 citations

Cisplatin-induced apoptosis of immortalized mouse proximal tubule cells is mediated by interleukin-1β converting enzyme (ICE) family of proteases but inhibited by overexpression of Bcl-2

1997 • 44 citations

Autocrine production and TGF-beta 1-mediated effects on metabolism and viability in renal cells

1996 • 44 citations

Effects of Hypoxia on Morphological and Biochemical Characteristics of Renal Epithelial Cell and Tubule Cultures

1992 • 43 citations

Apoptotic tubular cell death during acute renal allograft rejection.

1998 • 42 citations

Activation of NF-κB in Normal Rat Kidney Epithelial (NRK52E) Cells Is Mediated via a Redox-Insensitive, Calcium-Dependent Pathway

1999 • 42 citations

Role of caspases 1 and 3 and Bcl-2-related molecules in endothelial cell apoptosis associated with thrombotic microangiopathies

1998 • 42 citations

Endogenous EGF as a potential renotrophic factor in ischemia-induced acute renal failure

1993 • 39 citations

Growth factors and acute renal failure.

1998 • 36 citations

Expression of CD27 and ischemia/reperfusion-induced expression of its ligand Siva in rat kidneys

1998 • 32 citations

Increased p53 mRNA expression in liver and kidney apoptosis

1996 • 31 citations

A Role for c-myc in Chemically Induced Renal-Cell Death

1997 • 30 citations

Hepatocyte growth factor: Mesenchymal signal for epithelial homeostasis

1998 • 28 citations

CALCIUM BLOCKADE REDUCES RENAL APOPTOSIS DURING ISCHEMIA REPERFUSION

1997 • 28 citations

Distinct interleukin-1β-converting enzyme family proteases mediate cisplatin- and staurosporine-induced apoptosis of mouse proximal tubule cells

1998 • 27 citations

Uninephrectomy reduces apoptotic cell death and enhances renal tubular cell regeneration in ischemic ARF in rats

1996 • 25 citations

Urinary Epidermal Growth Factor Levels in Patients With Acute Renal Failure

1993 • 24 citations

Expression of bcl-2 oncoprotein in various types of glomerulonephritis and renal allografts

1996 • 22 citations

Fas antigen expression and its relationship with apoptosis in transplanted kidney

1997 • 22 citations

C-myc is not involved in cadmium-elicited apoptotic pathway in porcine kidney LLC-PK1 cells

1998 • 21 citations

Expression of Fas and Fas Ligand in Renal Grafts with Acute and Chronic Rejection in the Rat Model

1997 • 20 citations

Recent advances in understanding mechanisms of renal tubular injury.

1997 • 20 citations

Modulation of c-fos and egr-1 expression in the isolated perfused kidney by agents that alter tubular work

1997 • 15 citations

Involvement of macromolecule synthesis, endonuclease activation and c-fos expression in cisplatin-induced apoptosis of mouse proximal tubule cells

1998 • 14 citations

Expression of bcl-2 oncoprotein in various types of glomerulonephritis and renal allografts

1996 • 12 citations

Ha-ras oncogene expression abrogates a pH dependent endonuclease activity of apoptosis in normal rat kidney cells

1996 • 12 citations

Bcl-2 and Bax expression on rat ischemic kidney

1998 • 7 citations

Detection of TIA-1 cytotoxic T-lymphocytes and epithelial apoptotic cells in renal allograft biopsies.

1995 • 6 citations

Deleted Work

1955 • 0 citations