In-vitro effects of FSH and testosterone withdrawal on caspase activation and DNA fragmentation in different cell types of human seminiferous epithelium

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Detection of Deoxyribonucleic Acid Fragmentation in Human Sperm: Correlation with Fertilization in Vitro1

1997 • 772 citations

An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis

1997 • 599 citations

Presence of DNA Strand Breaks and Increased Sensitivity of DNA in Situ to Denaturation in Abnormal Human Sperm Cells: Analogy to Apoptosis of Somatic Cells

1993 • 485 citations

Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa

2000 • 480 citations

Abnormal Sperm Parameters in Humans Are Indicative of an Abortive Apoptotic Mechanism Linked to the Fas-Mediated Pathway

1999 • 350 citations

Study of apoptotic DNA fragmentation in human spermatozoa

2000 • 315 citations

Single Exposure to Heat Induces Stage-Specific Germ Cell Apoptosis in Rats: Role of Intratesticular Testosterone on Stage Specificity¹

1999 • 309 citations

The Fas System, a Regulator of Testicular Germ Cell Apoptosis, Is Differentially Up-Regulated in Sertoli Cell Versus Germ Cell Injury of the Testis*

1999 • 284 citations

Involvement of apoptosis in the induction of germ cell degeneration in adult rats after gonadotropin-releasing hormone antagonist treatment.

1995 • 240 citations

Susceptibility of Human Sperm toin SituDNA Denaturation Is Strongly Correlated with DNA Strand Breaks Identified by Single-Cell Electrophoresis

1997 • 228 citations

The role of DNA strand breaks in human spermatozoa used for IVF and ICSI

2000 • 190 citations

Fas regulates germ cell apoptosis in the human testis in vitro

1999 • 176 citations

Effects of Chemotherapy and Radiotherapy on Spermatogenesis

1993 • 167 citations

Measuring apoptosis in human spermatozoa: a biological assay for semen quality?

2000 • 166 citations

Spontaneous Germ Cell Apoptosis in Humans: Evidence for Ethnic Differences in the Susceptibility of Germ Cells to Programmed Cell Death

1998 • 163 citations

Apoptosis in the Rat Spermatogenic Epithelium Following Androgen Withdrawal: Changes in Apoptosis-Related Genes1

1999 • 163 citations

Significance of Apoptosis in the Temporal and Stage-Specific Loss of Germ Cells in the Adult Rat after Gonadotropin Deprivation1

1997 • 152 citations

Caspase-3 and Caspase-Activated Deoxyribonuclease Are Associated with Testicular Germ Cell Apoptosis Resulting from Reduced Intratesticular Testosterone

2001 • 148 citations

Germ cell apoptosis in men with complete and incomplete spermiogenesis failure

1998 • 142 citations

Human Spermatogenesis in Vitro: Respective Effects of Follicle-Stimulating Hormone and Testosterone on Meiosis, Spermiogenesis, and Sertoli Cell Apoptosis

1998 • 139 citations

Oxidative stress induces caspase-independent retinal apoptosis in vitro

2000 • 137 citations

The mode of chromosome duplication in Crepis capillaris

1958 • 132 citations

Apoptosis Is Physiologically Restricted to a Specialized Cytoplasmic Compartment in Rat Spermatids

1999 • 119 citations

Involvement of apoptosis in the induction of germ cell degeneration in adult rats after gonadotropin-releasing hormone antagonist treatment

1995 • 105 citations

Expression of Bcl-2 family proteins and spontaneous apoptosis in normal human testis

2001 • 101 citations

The Fas System, a Regulator of Testicular Germ Cell Apoptosis, Is Differentially Up-Regulated in Sertoli Cell Versus Germ Cell Injury of the Testis

1999 • 99 citations

Fas and Fas Ligand Expression in Fetal and Adult Human Testis with Normal or Deranged Spermatogenesis

2000 • 96 citations

The use of enzymatic procedures to recover testicular germ cells

1997 • 90 citations

DNA damage in round spermatids of mice with a targeted disruption of the Pp1cgamma gene and in testicular biopsies of patients with non-obstructive azoospermia

1999 • 78 citations

Caspase-Dependent and -Independent Events in Apoptosis Induced by Hydrogen Peroxide

2000 • 75 citations

Single Exposure to Heat Induces Stage-Specific Germ Cell Apoptosis in Rats: Role of Intratesticular Testosterone on Stage Specificity

1999 • 74 citations

2‐Methoxyacetic Acid (MAA)‐Induced Spermatocyte Apoptosis in Human and Rat Testes: An In Vitro Comparison

1996 • 69 citations

Spermatocyte Toxicity of 2-Methoxyethanol (ME) in Rats and Guinea Pigs: Evidence for the Induction of Apoptosis

1995 • 68 citations

Evidence that basement membrane prevents apoptosis of Sertoli cells in vitro in the absence of known regulators of Sertoli cell function.

1995 • 65 citations

Testosterone-induced inhibition of spermatogenesis is more closely related to suppression of FSH than to testicular androgen levels in the cynomolgus monkey model (Macaca fascicularis)

2001 • 65 citations

Partial Oxygen Pressure and Mitochondrial Permeability Transition Affect Germ Cell Apoptosis in the Human Testis¹

1999 • 45 citations

Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men

1994 • 45 citations

Spontaneous Germ Cell Apoptosis in Humans: Evidence for Ethnic Differences in the Susceptibility of Germ Cells to Programmed Cell Death

1998 • 40 citations

Transient oxidative stress in SH‐SY5Y human neuroblastoma cells results in caspase dependent and independent cell death and tau proteolysis

2000 • 36 citations

Caspase-3 and Caspase-Activated Deoxyribonuclease Are Associated with Testicular Germ Cell Apoptosis Resulting from Reduced Intratesticular Testosterone

2001 • 32 citations

In-vitro maturation of immature human male germ cells

2000 • 29 citations

Transient oxidative stress in SH-SY5Y human neuroblastoma cells results in caspase dependent and independent cell death and tau proteolysis

2000 • 29 citations

Partial Oxygen Pressure and Mitochondrial Permeability Transition Affect Germ Cell Apoptosis in the Human Testis

1999 • 29 citations

Fas and Fas Ligand Expression in Fetal and Adult Human Testis with Normal or Deranged Spermatogenesis

2000 • 29 citations

Human Spermatogenesis in Vitro: Respective Effects of Follicle-Stimulating Hormone and Testosterone on Meiosis, Spermiogenesis, and Sertoli Cell Apoptosis

1998 • 28 citations

Cell death patterns of the rat spermatogonial cell progeny induced by Sertoli cell geometric changes and Fas (CD95) agonist

1999 • 28 citations

In-vitro differentiation of germ cells from frozen testicular biopsy specimens

2000 • 26 citations

Inhibition of caspase activity does not prevent the signaling phase of apoptosis in prostate cancer cells

1999 • 26 citations

Serum-free induced neuronal apoptosis-like cell death is independent of caspase activity

2000 • 25 citations

The effect of FSH on male germ cell survival and differentiation in vitro is mimicked by pentoxifylline but not insulin

2000 • 24 citations

Evidence that basement membrane prevents apoptosis of Sertoli cells in vitro in the absence of known regulators of Sertoli cell function

1995 • 22 citations

Hormonal contraception in the male

2000 • 16 citations

Effects of androgen deprivation on the histology of adult chimpanzee testis

2001 • 12 citations

CpG-Specific Common Commitment in Caspase-Dependent and -Independent Cell Deaths

2000 • 9 citations

Immature germ cell conception—in vitro germ cell manipulation

2000 • 6 citations