Sphingosine 1-Phosphate Triggers Both Apoptotic and Survival Signals for Human Hepatic Myofibroblasts

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury

2000 • 2,078 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Ten years of protein kinase B signalling: a hard Akt to follow

2001 • 1,159 citations

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

1998 • 1,032 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 698 citations

Ceramide: an intracellular signal for apoptosis

1995 • 604 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Apoptosis‐inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

2000 • 459 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 458 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Tissue Inhibitor of Metalloproteinase-1 Is Mediated via Effects on Matrix Metalloproteinase Inhibition

2002 • 415 citations

Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats

2001 • 356 citations

Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors

2001 • 314 citations

Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibrogenic potential

1999 • 291 citations

Akt-Mediated Phosphorylation of the G Protein-Coupled Receptor EDG-1 Is Required for Endothelial Cell Chemotaxis

2001 • 284 citations

Sphingosine‐1‐phosphate: signaling inside and out

2000 • 275 citations

Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a GiProtein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells

2001 • 268 citations

Sphingosine 1-Phosphate May Be a Major Component of Plasma Lipoproteins Responsible for the Cytoprotective Actions in Human Umbilical Vein Endothelial Cells

2001 • 265 citations

Sphingosine 1-Phosphate and Activation of Endothelial Nitric-oxide Synthase

2001 • 241 citations

Sphingosine‐1‐Phosphate in Cell Growth and Cell Death^a

1998 • 202 citations

Sphingosine 1-Phosphate-induced Cell Proliferation, Survival, and Related Signaling Events Mediated by G Protein-coupled Receptors Edg3 and Edg5

2000 • 196 citations

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218

1999 • 183 citations

Hepatic Stellate Cells Express the Low Affinity Nerve Growth Factor Receptor p75 and Undergo Apoptosis in Response to Nerve Growth Factor Stimulation

2000 • 182 citations

The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering

1999 • 175 citations

TNF-α-Induced Sphingosine 1-Phosphate Inhibits Apoptosis Through a Phosphatidylinositol 3-Kinase/Akt Pathway in Human Hepatocytes

2001 • 163 citations

Transforming growth factor ? and tumor necrosis factor ? inhibit both apoptosis and proliferation of activated rat hepatic stellate cells

1999 • 162 citations

p38 Mitogen-activated Protein Kinase Pathway Protects Adult Rat Ventricular Myocytes against β-Adrenergic Receptor-stimulated Apoptosis

2000 • 161 citations

15-Deoxy-Δ12,14-prostaglandin J2 Induces Apoptosis of Human Hepatic Myofibroblasts

2001 • 158 citations

Role of NF-κB in the Antiproliferative Effect of Endothelin-1 and Tumor Necrosis Factor-α in Human Hepatic Stellate Cells

1998 • 158 citations

Death receptors couple to both cell proliferation and apoptosis

2002 • 139 citations

The pharmacology of apoptosis

1999 • 130 citations

Death receptors couple to both cell proliferation and apoptosis

2002 • 127 citations

Mitogenic effect of transforming growth factor-beta 1 on human Ito cells in culture: evidence for mediation by endogenous platelet-derived growth factor.

1993 • 127 citations

Antiproliferative Properties of Sphingosine 1-Phosphate in Human Hepatic Myofibroblasts

2000 • 117 citations

Growth inhibitory properties of endothelin-1 in human hepatic myofibroblastic Ito cells. An endothelin B receptor-mediated pathway.

1995 • 110 citations

Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors.

1996 • 103 citations

Transformation-dependent susceptibility of rat hepatic stellate cells to apoptosis induced by soluble fas ligand

1998 • 100 citations

Expression of the peripheral-type benzodiazepine receptor and apoptosis induction in hepatic stellate cells

2001 • 96 citations

Mitogenic effect of transforming growth factor-β1 on human ito cells in culture: Evidence for mediation by endogenous platelet-derived growth factor

1993 • 94 citations

Sphingosine‐1‐phosphate modulates growth and adhesion of ovarian cancer cells

1999 • 87 citations

Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes

1999 • 67 citations

Induction of apoptosis in rat hepatic stellate cells by disruption of integrin-mediated cell adhesion

1999 • 60 citations

Biological Effects of C-type Natriuretic Peptide in Human Myofibroblastic Hepatic Stellate Cells

1999 • 58 citations

Apoptotic Effect of Sphingosine 1-Phosphate and Increased Sphingosine 1-Phosphate Hydrolysis on Mesangial Cells Cultured at Low Cell Density

2002 • 46 citations

Induction of Apoptosis by Sphingosine-1-Phosphate in Human Hepatoma Cells Is Associated with Enhanced Expression of bax Gene Product

1996 • 38 citations

Distinct Effects of Different Calcium-Mobilizing Agents on Cell Death in NG108-15 Neuroblastoma X Glioma Cells

2002 • 24 citations