The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

1995 • 2,525 citations

Brain Corticosteroid Receptor Balance in Health and Disease*

1998 • 2,442 citations

A Trial of Etanercept, a Recombinant Tumor Necrosis Factor Receptor:Fc Fusion Protein, in Patients with Rheumatoid Arthritis Receiving Methotrexate

1999 • 2,117 citations

Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)

1990 • 1,307 citations

The Pathophysiologic Roles of Interleukin-6 in Human Disease

1998 • 1,132 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

Clinical and Biochemical Manifestations of Depression

1988 • 1,052 citations

Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids

1996 • 889 citations

Interleukin-2–Receptor Blockade with Daclizumab to Prevent Acute Rejection in Renal Transplantation

1998 • 875 citations

Responses to Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

1986 • 773 citations

Glucocorticoid Therapy for Immune-Mediated Diseases: Basic and Clinical Correlates

1993 • 762 citations

Corticotropin releasing factor produces behavioural activation in rats

1982 • 752 citations

Evidence for Impaired Activation of the Hypothalamic-Pituitary-Adrenal Axis in Patients with Chronic Fatigue Syndrome

1991 • 736 citations

Interactions between the Hypothalamic-Pituitary-Adrenal Axis and the Female Reproductive System: Clinical Implications

1998 • 692 citations

The Immune-Hypothalamic-Pituitary-Adrenal Axis*

1989 • 671 citations

Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.

1982 • 665 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans.

1993 • 555 citations

A Polymorphism in the Glucocorticoid Receptor Gene May Be Associated with an Increased Sensitivity to Glucocorticoidsin Vivo¹

1998 • 512 citations

Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo

1991 • 485 citations

Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

1995 • 470 citations

The Stress Response and the Regulation of Inflammatory Disease

1992 • 469 citations

Bone Mineral Density in Women with Depression

1996 • 458 citations

Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy.

1994 • 394 citations

Acute Effects of Recombinant Human Interleukin-6 on Endocrine and Central Nervous Sleep Functions in Healthy Men

1998 • 367 citations

Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions.

1978 • 267 citations

Corticotropin releasing hormone related behavioral and neuroendocrine responses to stress in Lewis and Fischer rats

1992 • 265 citations

Exercise and Circadian Rhythm-Induced Variations in Plasma Cortisol Differentially Regulate Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor-α (TNFα) Production in Humans: High Sensitivity of TNFα and Resistance of IL-6

1997 • 250 citations

Tumor Necrosis Factor as a Potent Inhibitor of Adrenocorticotropin-Induced Cortisol Production and Steroidogenic P450 Enzyme Gene Expression in Cultured Human Fetal Adrenal Cells*

1991 • 247 citations

Glucocorticoids inhibit the production of IL 6 from monocytes, endothelial cells and fibroblasts

1990 • 232 citations

Elevated Cerebrospinal Fluid Levels of Immunoreactive Corticotropin-Releasing Hormone in Anorexia Nervosa: Relation to State of Nutrition, Adrenal Function, and Intensity of Depression

1987 • 229 citations

Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial

1999 • 224 citations

Corticotropin-releasing hormone in synovial fluids and tissues of patients with rheumatoid arthritis and osteoarthritis.

1993 • 216 citations

Cytokine Regulation of Neuronal Survival

1992 • 209 citations

Glucocorticoid Effects on Somatomedins and Somatomedin Inhibitors*

1985 • 192 citations

Inhibition of basophil histamine release by anti-inflammatory steroids

1981 • 175 citations

Mechanisms of Serotonin Receptor Agonist-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis in the Rat

1990 • 167 citations

Corticotropin-Releasing Factor (Ovine) and Vasopressin Exert a Synergistic Effect on Adrenocorticotropin Release in Man

1984 • 166 citations

Glucocorticoid up-regulation of high-affinity interleukin 6 receptors on human epithelial cells.

1990 • 161 citations

Acute Administration of Corticoids: A New and Peculiar Stimulus of Growth Hormone Secretion in Man*

1990 • 136 citations

Disturbances of Menstruation in Thyroid Disease

1997 • 136 citations

Abnormal Pituitary-Adrenal Responses to Corticotropin-Releasing Hormone in Patients with Seasonal Affective Disorder: Clinical and Pathophysiological Implications

1991 • 135 citations

The dexamethasone suppression test in patients with primary obsessive-compulsive disorder

1982 • 130 citations

Cortisol receptor resistance: the variability of its clinical presentation and response to treatment.

1992 • 128 citations

Glucocorticoids inhibit eosinophil responses to granulocyte-macrophage colony-stimulating factor.

1991 • 128 citations

Regulation of apoptosis by steroid hormones

1995 • 121 citations

Differential adaptation of glucocorticoid sensitivity of peripheral blood mononuclear leukocytes in patients with sepsis or septic shock.

1995 • 121 citations

Cortisol resistance in acquired immunodeficiency syndrome.

1992 • 120 citations

In Vitroandin VivoEffects of the Triazolobenzodiazepine Alprazolam on Hypothalamic Pituitary-Adrenal Function: Pharmacological and Clinical Implications*

1990 • 114 citations

Biosynthesis of corticotropin-releasing hormone in human T-lymphocytes

1993 • 111 citations

Chapter 25 Modulation of brain aging correlates by long-term alterations of adrenal steroids and neurally-active peptides

1987 • 111 citations

Dexamethasone inhibits the induction of monocyte chemotactic-activating factor production by IL-1 or tumor necrosis factor.

1991 • 110 citations

Inhibition of interleukin-2-induced tumor necrosis factor release by dexamethasone: prevention of an acquired neutrophil chemotaxis defect and differential suppression of interleukin-2-associated side effects [see comments]

1990 • 109 citations

Stress and Reproduction: Physiologic and Pathophysiologic Interactions between the Stress and Reproductive Axes

1988 • 98 citations

ANTERIOR PITUITARY FUNCTION IN PATIENTS WITH NEWLY DIAGNOSED RHEUMATOID ARTHRITIS

1996 • 94 citations

Elevated urinary free cortisol in patients with dementia

1991 • 91 citations

Emotions and disease: From balance of humors to balance of molecules

1997 • 82 citations

Substance P Inhibits the Release of Anterior Pituitary Adrenocorticotrophin via a Central Mechanism Involving Corticotrophin‐Releasing Factor‐Containing Neurons in the Hypothalamic Paraventricular Nucleus

1993 • 71 citations

A comparison of the effects of human and ovine corticotropin-releasing hormone on the pituitary-adrenal axis.

1995 • 71 citations

Impairment of Adrenocortical Function Associated with Increased Plasma Tumor Necrosis Factor-Alpha and Interleukin-6 Concentrations in African Trypanosomiasis

1994 • 70 citations

Mechanisms of Glucocorticoid‐Resistant Asthma^a

1998 • 64 citations

Cortisol resistance in acquired immunodeficiency syndrome

1992 • 60 citations

Expression of Adrenocorticotropin-Releasing Hormone Precursor Gene in Placenta and Other Nonhypothalamic Tissues in Man

1988 • 58 citations

A Corticotropin-Releasing Hormone Type I Receptor Antagonist Delays Parturition in Sheep

1998 • 57 citations

Expression of Genes Encoding Corticotropin-Releasing Factor (CRF), Type 1 CRF Receptor, and CRF-Binding Protein and Localization of the Gene Products in the Human Ovary1

1997 • 52 citations

Human endothelial cells prolong eosinophil survival. Regulation by cytokines and glucocorticoids.

1989 • 51 citations

Increased plasma concentrations, hypothalamic content, and in vitro release of arginine vasopressin in inflammatory disease-prone, hypothalamic corticotropin-releasing hormone-deficient Lewis rats.

1992 • 50 citations

Presence of immunoreactive corticotropin releasing hormone in thyroid lesions.

1994 • 49 citations

Endothelial-secreted arachidonic acid metabolites modulate polymorphonuclear leukocyte chemotaxis and diapedesis in vitro

1988 • 48 citations

The role of lipocortin in corticosteroid actions.

1990 • 44 citations

A Two-Step Mechanism by Which Corticotropin- Releasing Hormone Releases Hypothalamic β-Endorphin: The Role of Vasopressin and G-Proteins*

1989 • 41 citations

Normal Bone Mass in Bulimic Women

1998 • 41 citations

HAEMODYNAMIC AND NEUROENDOCRINE CONSEQUENCES OF STOPPING SMOKING‐A CONTROLLED STUDY

1984 • 41 citations

Abnormal neuroendocrine immune communications in patients with rheumatoid arthritis

1992 • 32 citations

Chronic corticosterone treatment maintains synaptic activity of CA1 hippocampal pyramidal cells: Acute high corticosterone administration increases action potential number

1995 • 29 citations

Basic and Clinical Studies with Corticotropin-Releasing Hormone

1988 • 29 citations

Direct effects of corticotrophin-releasing hormone on stimulated growth hormone secretion

1998 • 27 citations

Assessment of stimulated and spontaneous adrenocorticotropin secretory dynamics identifies distinct components of cortisol feedback inhibition in healthy humans.

1996 • 25 citations

Cortisol catabolism by lymphocytes of patients with systemic lupus erythematosus and rheumatoid arthritis.

1990 • 19 citations

Potent and Selective Inhibition of in Vltro Lymphocyte Migration by Cyclosporine and Dexamethasone

1990 • 13 citations