Regulation of apoptosis by steroid hormones

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

1984 • 1,761 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

[The endocrine system].

1961 • 624 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Characterization of sgk, a Novel Member of the Serine/Threonine Protein Kinase Gene Family Which Is Transcriptionally Induced by Glucocorticoids and Serum

1993 • 537 citations

Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis.

1993 • 536 citations

Calcium‐activated DNA fragmentation kills immature thymocytes

1989 • 533 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Patterns of cell death.

1988 • 470 citations

Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis

1993 • 428 citations

Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation.

1993 • 419 citations

Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum.

1993 • 415 citations

Apoptosis: Cell death in tissue regulation

1987 • 393 citations

Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B.

1991 • 301 citations

Identification of mRNAs Associated with Programmed Cell Death in Immature Thymocytes

1991 • 286 citations

Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease

1993 • 279 citations

Periodicity of DNA folding in higher order chromatin structures.

1990 • 275 citations

Active cell death in hormone-dependent tissues

1992 • 264 citations

Identification of mRNAs associated with programmed cell death in immature thymocytes.

1991 • 242 citations

Delayed internucleosomal DNA fragmentation in programmed cell death

1993 • 222 citations

Rapidin VivoEffects of Glucocorticoids on the Integrity of Rat Lymphocyte Genomic Deoxyribonucleic Acid*

1986 • 218 citations

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

1992 • 195 citations

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.

1994 • 190 citations

Identification of a glucocorticoid-induced nuclease in thymocytes. A potential “lysis gene” product.

1987 • 167 citations

Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis

1993 • 167 citations

Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis.

1991 • 157 citations

Effects of cisplatin on the induction of apoptosis in proliferating hepatoma cells and nonproliferating immature thymocytes.

1993 • 149 citations

Apoptosis is induced by transforming growth factor-beta 1 within 5 hours in regressing liver without significant fragmentation of the DNA.

1993 • 142 citations

Endocrine therapy for advanced breast cancer: A review

1992 • 130 citations

A calcium-dependent nuclease from apoptotic rat thymocytes is homologous with cyclophilin. Recombinant cyclophilins A, B, and C have nuclease activity.

1994 • 130 citations

Calcium/magnesium-dependent endonuclease from human spleen: Purification, properties, and role in apoptosis

1993 • 123 citations

Cisplatin Induces Apoptosis in a Human Ovarian Carcinoma Cell Line without Concomitant Internucleosomal Degradation of DNA

1994 • 123 citations

Isolation and Characterization of Transcripts Induced by Androgen Withdrawal and Apoptotic Cell Death in the Rat Ventral Prostate

1991 • 120 citations

Cell Death Studies Yield Cancer Clues

1993 • 120 citations

Mg(2+)-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis.

1994 • 116 citations

Apoptosis is induced by transforming growth factor-β1 within 5 hours in regressing liver without significant fragmentation of the DNA

1993 • 111 citations

Characterization of uterine epithelium apoptotic cell death kinetics and regulation by progesterone and RU 486.

1992 • 109 citations

Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis.

1992 • 106 citations

Isolation and purification of calcium and magnesium dependent endonuclease from rat liver nuclei

1974 • 102 citations

Glucocorticoid Effect on Oncogene/Growth Gene Expression in Human T Lymphoblastic Leukemic Cell Line CCRF-CEM

1989 • 101 citations

Genes Newly Identified as Regulated by Glucocorticoids in Murine Thymocytes

1991 • 91 citations

Glucocorticoid inhibition of c-myc, c-myb, and c-Ki-ras expression in a mouse lymphoma cell line.

1986 • 82 citations

A Role for Calcium in Regulating Apoptosis in Rat Thymocytes Irradiatedin Vitro

1992 • 82 citations

Inhibition of apoptosis in human tumour cells by okadaic acid

1992 • 75 citations

Purification and Characterization of the Ca2+ Plus Mg2+-Dependent Endodeoxyribonuclease from Calf Thymus Chromatin1

1981 • 67 citations

Bcl‐2 inhibits glucocorticoid‐induced apoptosis but only partially blocks calcium ionophore or cycloheximide‐regulated apoptosis in S49 cells

1994 • 66 citations

Studies of the relationship between cell proliferation and cell death. II. Early gene expression during concanavalin A-induced proliferation or dexamethasone-induced apoptosis of rat thymocytes

1992 • 62 citations

Identification of a Gene Induced by Glucocorticoids in Murine T-Cells: A Potential G Protein-Coupled Receptor

1991 • 60 citations

Isolation of a cDNA clone, encoding a human β-galactoside binding protein, overexpressed during glucocorticoid-induced cell death

1991 • 60 citations

Inhibition of Poly(ADP-ribose) Polymerase as a Possible Reason for Activation of Ca²⁺/Mg²⁺-dependent Endonuclease in Thymocytes of Irradiated Rats

1988 • 55 citations

Synergistic induction of apoptosis with glucocorticoids and 3',5'-cyclic adenosine monophosphate reveals agonist activity by RU 486.

1993 • 55 citations

Identification and characterization of glucocorticoid-regulated nuclease(s) in lymphoid cells undergoing apoptosis

1991 • 53 citations

Transcription Factors′ DNA-Binding Activity in Rat Thymocytes Undergoing Apoptosis after Heat-Shock or Dexamethasone Treatment

1993 • 52 citations

Mapping the human glucocorticoid receptor for leukemic cell death

1991 • 48 citations

Neoadjuvant androgen blockade prior to prostatectomy: A retrospective study and critical review

1994 • 41 citations

Calmodulin can modulate protein phosphorylation in rat liver cells nuclei

1993 • 36 citations

Ca/Mg-dependent endonuclease from porcine liver. Purification, properties, and sequence specificity.

1984 • 36 citations

Tcl-30, a new T cell-specific gene expressed in immature glucocorticoid-sensitive thymocytes.

1992 • 27 citations

Synergistic induction of apoptosis with glucocorticoids and 3',5'- cyclic adenosine monophosphate reveals agonist activity by RU 486

1993 • 22 citations

Comparison of Glucocorticoid Receptors in Two Rat Hepatoma Cell Lines with Different Sensitivities to Glucocorticoids and Antiglucocorticoids

1988 • 20 citations

Early glucocorticoid induction of calmodulin and its suppression by corticotropin-releasing factor in pituitary corticotrope tumor (AtT20) cells

1992 • 20 citations

Glucocorticoid Regulation of the Genes Encoding Thymidine Kinase, Thymidylate Synthase, and Ornithine Decarboxylase in P1798 Cells

1988 • 19 citations

Glucocorticoid regulation of c-myc promoter utilization in P1798 T-lymphoma cells.

1992 • 16 citations

Characterization of glucocorticoid inhibition of antigen-induced inositolphosphate formation by rat basophilic leukemia cells: possible involvement of phosphatases

1991 • 11 citations

Analysis of protein kinase activities in rabbit ciliary processes: Identification and characterization using exogenous substrates

1987 • 10 citations

Glucocorticoid regulation of c-myc promoter utilization in P1798 T- lymphoma cells

1992 • 9 citations

[Isolation of Ca2+, Mg2+-dependent nuclease from calf thymus chromatin].

1989 • 9 citations

Characterization and Hormonal Regulation of Casein Kinase II Activity in Heterotransplanted Human Breast Tumors in Nude Mice

2009 • 8 citations