FOXP3 modifies the phenotypic and functional properties of regulatory T cells

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Regulatory T Cells

2000 • 1,827 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Transient expression of FOXP3 in human activated nonregulatory CD4⁺ T cells

2006 • 973 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

FOXP3: Of Mice and Men

2005 • 929 citations

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

2007 • 887 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

2006 • 773 citations

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2006 • 712 citations

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

2007 • 695 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

The lifestyle of naturally occurring CD4⁺CD25⁺Foxp3⁺ regulatory T cells

2006 • 589 citations

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

2003 • 574 citations

From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

2006 • 553 citations

Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells

2005 • 525 citations

Expression of the integrin α_Eβ₇identifies unique subsets of CD25⁺as well as CD25⁻regulatory T cells

2002 • 476 citations

Rules of chemokine receptor association with T cell polarization in vivo

2001 • 472 citations

Regulatory T cell development in the absence of functional Foxp3

2007 • 467 citations

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

2005 • 439 citations

Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans

2004 • 415 citations

Human CD4+CD25+ regulatory T cells

2004 • 389 citations

Macrophage Inflammatory Protein 3α Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors

2000 • 377 citations

X-linked lymphoreticular disease in the scurfy (sf) mutant mouse.

1991 • 339 citations

CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset

2004 • 314 citations

A Role for CD103 in the Retention of CD4+CD25+ Treg and Control of Leishmania major Infection

2005 • 313 citations

Analysis of FOXP3 Reveals Multiple Domains Required for Its Function as a Transcriptional Repressor

2006 • 267 citations

T-bet is required for optimal proinflammatory CD4+ T-cell trafficking

2005 • 260 citations

Transcriptional Regulation by Foxp3 Is Associated with Direct Promoter Occupancy and Modulation of Histone Acetylation

2006 • 230 citations

Regulatory T cells in autoimmunity

2007 • 228 citations

Multiple Domains Define the Expression and Regulatory Properties of Foxp1 Forkhead Transcriptional Repressors

2003 • 217 citations

INTEGRATION OF T CELL RECEPTOR–DEPENDENT SIGNALING PATHWAYS BY ADAPTER PROTEINS

1999 • 197 citations

Chemokines in Lymphocyte Trafficking and Intestinal Immunity

2003 • 178 citations

FOXP3: Not just for regulatory T cells anymore

2006 • 165 citations

The Amount of Scurfin Protein Determines Peripheral T Cell Number and Responsiveness

2001 • 152 citations

Separable effector T cell populations specialized for B cell help or tissue inflammation

2001 • 138 citations

CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy

2005 • 134 citations

FoxP3+ T Cells Undergo Conventional First Switch to Lymphoid Tissue Homing Receptors in Thymus but Accelerated Second Switch to Nonlymphoid Tissue Homing Receptors in Secondary Lymphoid Tissues

2007 • 123 citations

Chemokines in Lymphocyte Trafficking and Intestinal Immunity

2003 • 103 citations

Scurfin (FoxP3) Controls T-Dependent Immune Responses In Vivo Through Regulation of CD4+ T Cell Effector Function

2003 • 97 citations

Functional Flexibility in T Cells

2000 • 93 citations

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

2006 • 88 citations

Upregulation of Foxp3 Expression in Mouse and Human Treg Is IL‐2/STAT5 Dependent

2006 • 80 citations

FOXP3 ensembles in T‐cell regulation

2006 • 77 citations

Defective Activation of Protein Kinase C and Ras-ERK Pathways Limits IL-2 Production and Proliferation by CD4+CD25+ Regulatory T Cells

2006 • 76 citations

All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton

2003 • 69 citations

Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities☆

2004 • 69 citations

Cytoskeletal remodeling in lymphocyte activation

2003 • 69 citations

Functional and Molecular Comparison of Anergic and Regulatory T Lymphocytes

2006 • 64 citations

Interplay between TCR signalling and actin cytoskeleton dynamics

2004 • 52 citations

The Yins of T Cell Activation

2005 • 50 citations

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a model of immune dysregulation

2002 • 46 citations

Dynamic regulation of FoxP3 expression controls the balance between CD4⁺ T cell activation and cell death

2005 • 41 citations

Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells

2006 • 41 citations

Impaired T Cell Receptor Signaling in Foxp3⁺ CD4 T Cells

2007 • 29 citations