Immunotherapy Targeting 4-1BB and Its Ligand

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Signalling pathways of the TNF superfamily: a double-edged sword

2003 • 2,602 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

The signaling adaptors and pathways activated by TNF superfamily

2003 • 481 citations

Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB

2002 • 438 citations

Inducible T cell antigen 4-1BB. Analysis of expression and function.

1993 • 416 citations

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

1999 • 379 citations

NK1.1 Cells Express 4-1BB (CDw137) Costimulatory Molecule and Are Required for Tumor Immunity Elicited by Anti-4-1BB Monoclonal Antibodies

1998 • 361 citations

Molecular cloning of a ligand for the inducible T cell gene 4‐1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor

1993 • 328 citations

4-1BB-mediated immunotherapy of rheumatoid arthritis

2004 • 324 citations

Role of 4-1BB in immune responses

1998 • 312 citations

Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells

2002 • 285 citations

Analysis of 4-1BB Ligand (4-1BBL)-Deficient Mice and of Mice Lacking Both 4-1BBL and CD28 Reveals a Role for 4-1BBL in Skin Allograft Rejection and in the Cytotoxic T Cell Response to Influenza Virus

1999 • 280 citations

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

2002 • 265 citations

4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses

1999 • 259 citations

Cutting Edge: Expression of Functional CD137 Receptor by Dendritic Cells

2002 • 231 citations

4‐1BB T‐cell antigen binds to mature B cells and macrophages, and costimulates anti‐μ‐primed splenic B cells

1994 • 223 citations

Immune Responses in 4-1BB (CD137)-Deficient Mice

2002 • 221 citations

Administration of Agonistic Anti-4-1BB Monoclonal Antibody Leads to the Amelioration of Experimental Autoimmune Encephalomyelitis

2002 • 193 citations

Anti–4-1bb Monoclonal Antibodies Abrogate T Cell–Dependent Humoral Immune Responses in Vivo through the Induction of Helper T Cell Anergy

1999 • 184 citations

Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28.

1995 • 181 citations

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

2002 • 178 citations

Signaling Through NK Cell-Associated CD137 Promotes Both Helper Function for CD8+ Cytolytic T Cells and Responsiveness to IL-2 But Not Cytolytic Activity

2002 • 177 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 174 citations

Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB

2002 • 162 citations

4-1BB Costimulation Is Required for Protective Anti-Viral Immunity After Peptide Vaccination

2000 • 143 citations

4-1BB-Specific Monoclonal Antibody Promotes the Generation of Tumor-Specific Immune Responses by Direct Activation of CD8 T Cells in a CD40-Dependent Manner

2002 • 138 citations

Anti-CD137 Monoclonal Antibody Administration Augments the Antitumor Efficacy of Dendritic Cell-Based Vaccines

2004 • 113 citations

CD137-Deficient Mice Have Reduced NK/NKT Cell Numbers and Function, Are Resistant to Lipopolysaccharide-Induced Shock Syndromes, and Have Lower IL-4 Responses

2004 • 96 citations

In Vivo Triggering Through 4-1BB Enables Th-Independent Priming of CTL in the Presence of an Intact CD28 Costimulatory Pathway

2002 • 92 citations

Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering

2003 • 71 citations

Stimulation with 4-1BB (CD137) inhibits chronic graft-versus-host disease by inducing activation-induced cell death of donor CD4+ T cells

2004 • 71 citations

Provision of 4-1BB Ligand Enhances Effector and Memory CTL Responses Generated by Immunization with Dendritic Cells Expressing a Human Tumor-Associated Antigen

2003 • 70 citations

4-1BB-ligand is regulated on human dendritic cells and induces the production of IL-12

2003 • 67 citations

Novel T cell antigen 4-1BB associates with the protein tyrosine kinase p56lck1.

1993 • 62 citations

Regulation of 4‐1BB expression by cell‐cell interactions and the cytokines, interleukin‐2 and interleukin‐4

1995 • 62 citations

Blocking 4-1BB/4-1BB Ligand Interactions Prevents Herpetic Stromal Keratitis

2003 • 60 citations

Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice

2001 • 60 citations

Anti-CD137 Antibodies in the Treatment of Autoimmune Disease and Cancer

2004 • 60 citations

Regulation of Dendritic Cell Function by NK Cells: Mechanisms Underlying the Synergism in the Combination Therapy of IL-12 and 4-1BB Activation

2004 • 55 citations

Expression of tumour necrosis factor (TNF) ligand superfamily co‐stimulatory molecules CD30L, CD27L, OX40L, and 4‐1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3

2001 • 50 citations

Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival

2004 • 49 citations

Tumor Expression of 4-1BB Ligand Sustains Tumor Lytic T Cells

2003 • 36 citations

Therapeutic vaccination with tumor cells that engage CD137

2003 • 30 citations

Regulation of Follicular Dendritic Cell Networks by Activated T Cells: The Role of CD137 Signaling

2005 • 29 citations

A novel adenovirus expressing human 4–1BB ligand enhances antitumor immunity

2003 • 26 citations

Murine keratocytes function as antigen-presenting cells

2001 • 22 citations

Analysis of costimulation by 4-1BBL, CD40L, and B7 in graft rejection by gene expression profiles

2003 • 8 citations