Costimulatory molecule-targeted immunotherapy of cutaneous graft-versus-host disease

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Total Body Irradiation and Acute Graft-Versus-Host Disease: The Role of Gastrointestinal Damage and Inflammatory Cytokines

1997 • 838 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Memory CD4+ T cells do not induce graft-versus-host disease

2003 • 426 citations

A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis

1997 • 410 citations

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

1999 • 379 citations

4-1BB-mediated immunotherapy of rheumatoid arthritis

2004 • 324 citations

Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma.

1999 • 297 citations

Scleroderma: from cell and molecular mechanisms to disease models

2005 • 275 citations

Murine Sclerodermatous Graft-Versus-Host Disease, a Model for Human Scleroderma: Cutaneous Cytokines, Chemokines, and Immune Cell Activation

2002 • 257 citations

Anti-TGF-β Treatment Prevents Skin and Lung Fibrosis in Murine Sclerodermatous Graft-Versus-Host Disease: A Model for Human Scleroderma

1999 • 248 citations

Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets

2000 • 232 citations

Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease

2006 • 229 citations

Donor CD4+ T and B cells in transplants induce chronic graft-versus-host disease with autoimmune manifestations

2005 • 212 citations

Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ

2004 • 209 citations

Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease

2004 • 208 citations

Target Antigens Determine Graft-versus-Host Disease Phenotype

2004 • 203 citations

Polymorphism of murine Fas ligand that affects the biological activity

1997 • 201 citations

In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses

2002 • 195 citations

Administration of Agonistic Anti-4-1BB Monoclonal Antibody Leads to the Amelioration of Experimental Autoimmune Encephalomyelitis

2002 • 193 citations

Anti–4-1bb Monoclonal Antibodies Abrogate T Cell–Dependent Humoral Immune Responses in Vivo through the Induction of Helper T Cell Anergy

1999 • 184 citations

Chronic graft-versus-host disease (GVHD) as a model for scleroderma

1983 • 182 citations

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

2002 • 178 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 174 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 152 citations

New approaches for preventing and treating chronic graft-versus-host disease

2005 • 143 citations

Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo

2003 • 106 citations

GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease

2004 • 103 citations

Cutaneous Gene Expression by DNA Microarray in Murine Sclerodermatous Graft-Versus-Host Disease, a Model for Human Scleroderma

2006 • 95 citations

L3T4-positive T cells participate in the induction of graft-vs-host disease in response to minor histocompatibility antigens.

1987 • 92 citations

CD137-mediated immunotherapy for allergic asthma

2006 • 88 citations

Engagement of the CD137 (4‐1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen‐induced arthritis and establishes lasting disease resistance

2004 • 77 citations

Stimulation with 4-1BB (CD137) inhibits chronic graft-versus-host disease by inducing activation-induced cell death of donor CD4+ T cells

2004 • 71 citations

CD28 ligation induces transplantation tolerance by IFN-γ–dependent depletion of T cells that recognize alloantigens

2004 • 68 citations

Functions of newly identified members of the tumor necrosis factor receptor/ligand superfamilies in lymphocytes

1999 • 67 citations

New insights into the role of 4-1BB in immune responses: beyond CD8+ T cells

2002 • 63 citations

Engagement of 4-1BB Inhibits the Development of Experimental Allergic Conjunctivitis in Mice

2005 • 59 citations

CD137‐induced apoptosis is independent of CD95

1999 • 53 citations

Conversion of Alloantigen-Specific CD8+ T Cell Anergy to CD8+ T Cell Priming through In Vivo Ligation of Glucocorticoid-Induced TNF Receptor

2006 • 33 citations

Anti-CD137 mAb Treatment Inhibits Experimental Autoimmune Uveitis by Limiting Expansion and Increasing Apoptotic Death of Uveitogenic T Cells

2005 • 32 citations

Inhibition of Th2-Mediated Allergic Airway Inflammatory Disease by CD137 Costimulation

2006 • 31 citations

Update on Graft versus Host Disease

2004 • 29 citations

Diffuse biliary tract involvement mimicking primary sclerosing cholangitis in an experimental model of chronic graft‐versus‐host disease in mice

1998 • 26 citations

Hepatic lesions in murine chronic graft-versus-host disease to minor histocompatibility antigens. A reproducible model of nonsuppurative destructive cholangitis.

1989 • 23 citations

CONTRIBUTIONS OF DONOR CD4 AND CD8 CELLS TO LIVER INJURY DURING MURINE GRAFT-VERSUS-HOST DISEASE1

1996 • 23 citations

Histological changes in the liver in experimental graft-versus-host disease across minor histocompatibility barriers. VI. A light and electron microscopic study of the periportal changes

1991 • 21 citations

4‐1BB stimulation inhibits allergen‐specific immunoglobulin E production and airway hyper‐reactivity but partially suppresses bronchial eosinophilic inflammation in a mouse asthma model

2006 • 21 citations

Hepatic lesions in murine chronic graft-versus-host disease to minor histocompatibility antigens. A reproducible model of nonsuppurative destructive cholangitis.

1989 • 9 citations

Histological changes of the liver in experimental graft-versus-host disease across minor histocompatibility barriers. VII. A light and electron microscopic study of the large bile duct

1993 • 6 citations