Molecular Mechanisms Linking Thrombosis and Angiogenesis in Cancer

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Hemostasis and Thrombosis: Basic Principles and Clinical Practice.

1988 • 1,817 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

1989 • 1,282 citations

Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.

1989 • 1,199 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

1995 • 1,087 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Interleukin 6 Induces the Expression of Vascular Endothelial Growth Factor

1996 • 1,031 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration.

1990 • 857 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

1995 • 764 citations

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

1996 • 726 citations

Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.

1994 • 702 citations

Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.

1995 • 699 citations

Role of tissue factor in embryonic blood vessel development

1996 • 693 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia

1996 • 639 citations

Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

1995 • 608 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease

1996 • 544 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice.

1994 • 488 citations

Hypoxia Induces Vascular Endothelial Growth Factor in Cultured Human Endothelial Cells

1995 • 487 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

1994 • 453 citations

Cell biology of tissue factor, the principal initiator of blood coagulation

1996 • 418 citations

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.

1995 • 409 citations

Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis.

1992 • 367 citations

Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1 β in Rat Aortic Smooth Muscle Cells

1995 • 347 citations

Thrombospondins: structure and regulation of expression

1992 • 345 citations

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation.

1996 • 340 citations

Angiogenesis in malignant gliomas

1995 • 340 citations

Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells

1995 • 336 citations

Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.

1992 • 309 citations

Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.

1995 • 303 citations

Possible Participation of Autocrine and Paracrine Vascular Endothelial Growth Factors in Hypoxia-induced Proliferation of Endothelial Cells and Pericytes

1995 • 300 citations

Hemostatic alterations in cancer patients

1992 • 284 citations

Regulation of the tissue factor gene

1995 • 275 citations

pp60c-src activation in human colon carcinoma.

1989 • 267 citations

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

1990 • 264 citations

Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA.

1987 • 251 citations

Crystal structure of the extracellular region of human tissue factor

1994 • 218 citations

Hypoxia regulatory elements of the human vascular endothelial growth factor gene.

1994 • 196 citations

Detection and characterization of cellular EGR-1 binding to its recognition site

1993 • 193 citations

A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum

1988 • 187 citations

Binding of Human Factor VIIa to Tissue Factor Induces Cytosolic Ca2+ Signals in J82 Cells, Transfected COS-1 Cells, Madin-Darby Canine Kidney Cells and in Human Endothelial Cells Induced to Synthesize Tissue Factor

1995 • 175 citations

Thrombosis and cancer

1987 • 170 citations

Transcriptional Regulation of the Tissue Factor Gene in Human Epithelial Cells Is Mediated by Sp1 and EGR-1

1996 • 160 citations

Pathways of Coagulation/Fibrinolysis Activation in Malignancy

1992 • 159 citations

Tyrosine Phosphorylation of Phospholipase C-II in Vitro by the Epidermal Growth Factor Receptor

1989 • 145 citations

Role of Platelets, Thrombin, Integrin llb-llla, Fibronectin and Von Willebrand Factor on Tumor Adhesion in Vitro and Metastasis in Vivo

1995 • 142 citations

Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C.

1992 • 135 citations

A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor.

1989 • 129 citations

Characterization of an Krox-24/Egr-1-responsive element in the human tumor necrosis factor promoter

1994 • 126 citations

VEGF-mediated tumour angiogenesis: a new target for cancer therapy

1995 • 126 citations

The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism.

1992 • 125 citations

Lipopolysaccharide Induction of Tissue Factor Gene Expression in Monocytic Cells Is Mediated by Binding of c-Rel/p65 Heterodimers to a κB-Like Site

1994 • 118 citations

Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells.

1995 • 103 citations

Expression of raf oncogenes activates the PEA1 transcription factor motif.

1989 • 101 citations

Fibrin activation of vascular endothelial cells. Induction of IL-8 expression.

1995 • 99 citations

An anti-tissue factor monoclonal antibody which inhibits TF.VIIa complex is a potent anticoagulant in plasma.

1991 • 96 citations

Molecular Basis of Thrombosis and Hemostasis

1995 • 95 citations

Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene.

1994 • 87 citations

Xa receptor EPR‐1

1995 • 86 citations

Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease complex.

1992 • 84 citations

Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker.

1995 • 79 citations

Activation of the Serum Response Element and 12-O-Tetradecanoylphorbol-13-Acetate Response Element by the Activated c-raf-1 Protein in a Manner Independent of Protein Kinase C

1989 • 71 citations

Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a kappa B-like site.

1994 • 68 citations

An Anti-Tissue Factor Monoclonal Antibody which Inhibits TF Vlla Complex Is a Potent Anticoagulant in Plasma

1991 • 67 citations

The role of thrombin in tumor cell metastasis.

1994 • 59 citations

Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma.

1996 • 59 citations

Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers

1994 • 58 citations

Lysine residues 165 and 166 are essential for the cofactor function of tissue factor.

1991 • 53 citations

The Phosphorylated Forms of the Transcription Factor, Egr-1, Bind to DNA More Efficiently than Non-phosphorylated

1994 • 44 citations

Regulation of tissue factor gene expression in epithelial cells. Induction by serum and phorbol 12-myristate 13-acetate.

1994 • 39 citations

Fibrin induction of tissue factor expression in human vascular endothelial cells.

1997 • 37 citations

Thrombospondin as a mediator of cancer cell adhesion in metastasis

1992 • 33 citations

Lipopolysaccharide Induction of THP-1 Cells Activates Binding of c-Jun, Ets, and Egr-1 to the Tissue Factor Promoter

1996 • 31 citations

Protein kinase c regulates cytokine-induced tissue factor transcription and procoagulant activity in human endothelial cells

1996 • 30 citations

Disorders of Thrombosis

1995 • 29 citations