The blood platelet as a model for regulating blood coagulation on cell surfaces and its consequences.

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Hemostasis and Thrombosis: Basic Principles and Clinical Practice.

1988 • 1,817 citations

The coagulation cascade: initiation, maintenance, and regulation

1991 • 1,810 citations

PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes

1989 • 878 citations

Surface-dependent reactions of the vitamin K-dependent enzyme complexes

1990 • 853 citations

Factor XI Activation in a Revised Model of Blood Coagulation

1991 • 774 citations

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

1996 • 726 citations

Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides

1990 • 710 citations

Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140

1989 • 653 citations

The platelet-derived growth factor

1978 • 649 citations

Roles of Infectious Agents in Atherosclerosis and Restenosis

1997 • 566 citations

Biochemistry and Physiology of Blood Coagulation

1999 • 459 citations

Heparin induces release of extrinsic: Coagulation pathway inhibitor (EPI)

1988 • 401 citations

Regulation of coagulation by a multivalent Kunitz-type inhibitor

1990 • 366 citations

Cellular consequences of thrombin-receptor activation

1996 • 341 citations

Platelet‐derived growth factor is a chemoattractant for vascular smooth muscle cells

1982 • 340 citations

The Hemostatic System as a Regulator of Angiogenesis

2000 • 322 citations

Actions of Thrombin and Other Coagulant and Proteolytic Enzymes on Blood Platelets

1967 • 314 citations

Peripheral Blood Platelets Express VEGF-C and VEGF which Are Released during Platelet Activation

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Chemotactic activity of platelet alpha granule proteins for fibroblasts.

1983 • 275 citations

Characterization of a functional thrombin receptor. Issues and opportunities.

1992 • 274 citations

Thrombin functions as an inflammatory mediator through activation of its receptor.

1996 • 260 citations

Plasma antigen levels of the lipoprotein-associated coagulation inhibitor in patient samples

1991 • 239 citations

Selectin-mediated rolling of neutrophils on immobilized platelets

1993 • 236 citations

Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion.

1989 • 198 citations

Human prothrombinase complex assembly and function on isolated peripheral blood cell populations.

1985 • 196 citations

Tissue Factor in the Pathogenesis of Atherosclerosis

1997 • 192 citations

Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus.

1992 • 190 citations

Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: Interaction of thrombospondin with fibronectin and collagen

1982 • 177 citations

Signaling through G Proteins in Platelets: to the Integrins and Beyond

1997 • 172 citations

Functional characterization of human platelet-released factor V and its activation by factor Xa and thrombin.

1990 • 170 citations

Thrombin immobilized to extracellular matrix is a potent mitogen for vascular smooth muscle cells: nonenzymatic mode of action.

1990 • 167 citations

Kinetics of factor Xa inhibition by tissue factor pathway inhibitor.

1993 • 166 citations

Factor Va-dependent binding of factor Xa to human platelets.

1980 • 150 citations

Inhibition of tumor growth in mice by an analogue of platelet factor 4 that lacks affinity for heparin and retains potent angiostatic activity.

1991 • 148 citations

The Effects of Platelet-Derived Growth Factor in Cultured Microvessel Endothelial Cells*

1989 • 137 citations

Thrombospondin binds to monocytes-macrophages and mediates platelet-monocyte adhesion.

1987 • 135 citations

The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin

1987 • 128 citations

Role of thrombin receptor in breast cancer invasiveness

1999 • 114 citations

Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin.

1995 • 112 citations

Kinetics of coagulation factor-X activation by platelet-bound factor IXa

1990 • 110 citations

Human β-thromboglobulin inhibits PGI2 production and binds to a specific site in bovine aortic endothelial cells

1979 • 108 citations

Human Brain Pericytes Differentially Regulate Expression of Procoagulant Enzyme Complexes Comprising the Extrinsic Pathway of Blood Coagulation

1997 • 104 citations

Factor VIIa-induced p44/42 Mitogen-activated Protein Kinase Activation Requires the Proteolytic Activity of Factor VIIa and Is Independent of the Tissue Factor Cytoplasmic Domain

1999 • 104 citations

Human platelet-derived mitogens. II. Subcellular localization of insulinlike growth factor I to the alpha-granule and release in response to thrombin

1989 • 93 citations

Thrombin as a regulator of inflammation and reparative processes in tissues.

2001 • 93 citations

The effect of von Willebrand factor on activation of factor VIII by factor Xa

1990 • 90 citations

A coagulation pathway on bovine aortic segments leading to generation of Factor Xa and thrombin.

1984 • 90 citations

Plasma factor VII and thrombin–antithrombin III levels indicate increased tissue factor activity in sickle cell patients

1992 • 89 citations

Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promoting cell proliferation induced by G-protein-coupled receptor agonist.

1996 • 87 citations

Activation of Mac-1 (CD11b/CD18)-bound factor X by released cathepsin G defines an alternative pathway of leucocyte initiation of coagulation

1996 • 85 citations

Platelet Signal Transduction Pathways: Could We Organize Them into a ‘Hierarchy’?

1999 • 84 citations

Platelet-derived growth factor stimulates mouse 3T3 cell mitogenesis and leukocyte chemotaxis through different structural determinants.

1983 • 81 citations

Effector Cell Protease Receptor-1 Is a Vascular Receptor for Coagulation Factor Xa

1996 • 79 citations

Tissue Factor: a Complex Biological Role

1997 • 77 citations

Megakaryocyte synthesis is the source of epidermal growth factor in human platelets.

1990 • 77 citations

Molecular Mechanisms of Platelet Aggregation

1986 • 75 citations

Platelet-Derived Factor Va/VaLeiden Cofactor Activities Are Sustained on the Surface of Activated Platelets Despite the Presence of Activated Protein C

1998 • 73 citations

Sweeping flight and soaring by albatrosses

1975 • 69 citations

Kinetics of the Inhibition of Factor Xa and the Tissue Factor-Factor VIIa Complex by the Tissue Factor Pathway Inhibitor in the Presence and Absence of Heparin

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SERPIN Regulation of Factor XIa

2000 • 59 citations

Thrombin generation and secretion of platelet Factor 4 during blood clotting.

1978 • 55 citations

Aggregating Human Platelets Stimulate the Expression of Thrombin Receptors in Cultured Vascular Smooth Muscle Cells via the Release of Transforming Growth Factor-β ₁ and Platelet-Derived Growth Factor _AB

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Proteases and protease receptors in modulation of leukocyte effector functions

1995 • 49 citations

Thrombin Interactions with Platelet Membrane Proteins^a

1986 • 49 citations

Vitronectin (S protein) is associated with platelets

1989 • 47 citations

The activation of human blood coagulation factor X on the surface of endothelial cells: a comparison with various vascular cells, platelets and monocytes

1994 • 45 citations

Activation of Prothrombin by Factor Xa Bound to the Membrane Surface of Human Umbilical Vein Endothelial Cells: Its Catalytic Efficiency Is Similar to That of Prothrombinase Complex on Platelets

1995 • 43 citations

Kinetics of the inhibition of tissue factor-factor VIIa by tissue factor pathway inhibitor.

1995 • 43 citations

Tissue Factor Pathway Inhibitor

1994 • 43 citations

Identification of a new class of inducible receptors on platelets. Thrombospondin interacts with platelets via a GPIIb-IIIa-independent mechanism.

1986 • 41 citations

Role of High-Affinity Thrombin Receptors in Postclotting Cellular Effects of Thrombin

1992 • 41 citations

Functional thrombin receptors on human T lymphoblastoid cells.

1993 • 40 citations

Adhesion of Blood Platelets to the Extracellular Matrix of Cultured Human Endothelial Cells

1987 • 38 citations

Thrombin in inflammation and healing: relevance to rheumatoid arthritis.

1994 • 38 citations

Binding of Thrombin to the G-protein-linked Receptor, and Not to Glycoprotein Ib, Precedes Thrombin-mediated Platelet Activation

1997 • 36 citations

Platelets, Macrophages, Endothelium, and Growth Factors Their Effects upon Cells and their Possible Roles in Atherogenesis

1985 • 35 citations

Treatment with Simvastatin and Low-dose Aspirin Depresses Thrombin Generation in Patients with Coronary Heart Disease and Borderline-high Cholesterol Levels

2001 • 35 citations

Elevated urinary levels of thromboxane and prostacyclin metabolites in sickle cell disease reflects activated platelets in the circulation

1994 • 33 citations

Factor X Bound to the Surface of Activated Human Platelets Is Preferentially Activated by Platelet-Bound Factor IXa

1996 • 32 citations

A form of protease nexin I is expressed on the platelet surface during platelet activation

1989 • 30 citations

Secreted ADP Plays a Central Role in Thrombin-induced Phospholipase D Activation in Human Platelets

1998 • 26 citations

Plasma and urinary leukotrienes in sickle cell disease: possible role in the inflammatory process

1994 • 25 citations

Cellular Consequences of the Initiation of Blood Coagulation

1999 • 24 citations

Probable regulation of factor VIIa–tissue factor and prothrombinase by factor Xa–TFPI and TFPI in vivo

1996 • 24 citations

Endothelial Cell Processing of von Willebrand Proteins^a

1987 • 23 citations

Regulation of Neurons and Astrocytes by Thrombin and Protease Nexin-1

1997 • 23 citations

Platelets and Factor XI Bypass the Contact System of Blood Coagulation

1999 • 22 citations

Assembly of the prothrombin activator complex on rabbit alveolar macrophage high-affinity factor Xa receptors. A kinetic study.

1986 • 19 citations

Activation of factor V during intrinsic and extrinsic coagulation. Inhibition by heparin, hirudin and <scp>d</scp>-Phe-Pro-Arg-Ch2Cl

1990 • 19 citations

Relaxant and Contractile Responses of Porcine Pulmonary Arteries to Thrombin and Thrombin Receptor Activating Peptides

1996 • 19 citations

Release of different fractions of epidermal growth factor from human platelets in vitro: preferential release of 140 kDa fraction

1992 • 18 citations

Protease Nexin II Interactions with Coagulation Factor XIa Are Contained within the Kunitz Protease Inhibitor Domain of Protease Nexin II and the Factor XIa Catalytic Domain

2000 • 17 citations

Atherogenic Regulation by Heparin‐like Molecules^a

1985 • 10 citations

Regulation of Platelet Factor Va-dependent Thrombin Generation by Activated Protein C at the Surface of Collagen-adherent Platelets

2001 • 10 citations

Surface-dependent Coagulation Enzymes

2001 • 7 citations

Platelets and Intimal Thickening

1994 • 4 citations