Pathogenetic Mechanisms of Thrombosis in Malignancy

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Rates of Initial and Recurrent Thromboembolic Disease Among Patients with Malignancy Versus Those without Malignancy: Risk Analysis Using Medicare Claims Data

1999 • 890 citations

Prevention of Venous Thromboembolism in General Surgical Patients

1988 • 696 citations

Deep-Vein Thrombosis and the Incidence of Subsequent Symptomatic Cancer

1992 • 689 citations

Basic and clinical aspects of fibrinolysis and thrombolysis

1991 • 653 citations

The Risk of a Diagnosis of Cancer after Primary Deep Venous Thrombosis or Pulmonary Embolism

1998 • 613 citations

In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease

1996 • 544 citations

Double-blind randomised trial of very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer

1994 • 517 citations

Venous thromboembolism and cancer

1998 • 515 citations

Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice.

1994 • 488 citations

The Thrombogenic Effect of Anticancer Drug Therapy in Women with Stage II Breast Cancer

1988 • 424 citations

Venous and arterial thrombosis in patients who received adjuvant therapy for breast cancer.

1991 • 399 citations

Clinical Impact of the Plasminogen Activation System in Tumor Invasion and Metastasis: Prognostic Relevance and Target for Therapy

1997 • 391 citations

Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture

1989 • 337 citations

Incidence of Cancer after Prophylaxis with Warfarin against Recurrent Venous Thromboembolism

2000 • 332 citations

Hemostatic alterations in cancer patients

1992 • 284 citations

Polymorphonuclear leukocyte activation and hemostasis in patients with essential thrombocythemia and polycythemia vera

2000 • 267 citations

Pathophysiology of the Thrombophilic State in the Cancer Patient

1999 • 249 citations

Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer.

1998 • 249 citations

Deep venous thrombosis and occult malignancy: an epidemiological study

1994 • 236 citations

Isolation and characterization of cancer procoagulant: a cysteine proteinase from malignant tissue

1985 • 213 citations

The Impact of All-trans-Retinoic Acid on the Coagulopathy of Acute Promyelocytic Leukemia

1998 • 213 citations

Correlation between spontaneous metastatic potential, platelet-aggregating activity of cell surface extracts, and cell surface sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma cell line.

1980 • 192 citations

Tissue Factor in Health and Disease

1997 • 187 citations

Tumor necrosis factor induces tissue factor-like activity in human leukemia cell line U937 and peripheral blood monocytes

1988 • 166 citations

Neutrophil Activation and Hemostatic Changes in Healthy Donors Receiving Granulocyte Colony-Stimulating Factor

1999 • 158 citations

Occult Cancer in Patients with Venous Thromboembolism: which Patients, which Cancers

1997 • 149 citations

Tissue-factor expression in human non-small-cell lung carcinoma measured by immunohistochemistry: Correlation between tissue factor and angiogenesis

1998 • 141 citations

Cancer and Thrombosis: from Phlegmasia Alba Dolens to Transgenic Mice

1995 • 141 citations

Tissue factor in cancer angiogenesis and metastasis

1996 • 136 citations

Loss of blast cell procoagulant activity and improvement of hemostatic variables in patients with acute promyelocytic leukemia administered all-trans-retinoic acid

1995 • 135 citations

A new procoagulant in acute leukemia

1988 • 128 citations

Effects of chemotherapeutic drugs on platelet and metastatic tumor cell-endothelial cell interactions as a model for assessing vascular endothelial integrity.

1985 • 121 citations

Cellular Receptors in the Regulation of Plasmin Generation

1995 • 120 citations

MALIGNANCY AND HAEMOSTASIS

1980 • 117 citations

Cancer procoagulant in human tumor cells: evidence from melanoma patients.

1986 • 113 citations

All‐trans‐RETINOIC ACID INCREASES ADHESION TO ENDOTHELIUM OF THE HUMAN PROMYELOCYTIC LEUKAEMIA CELL LINE NB4

1996 • 112 citations

Monocytes Upregulate Endothelial Cell Expression of Tissue Factor: A Role for Cell-Cell Contact and Cross-Talk

1997 • 110 citations

Platelet/polymorphonuclear leukocyte adhesion: a new role for SRC kinases in Mac-1 adhesive function triggered by P-selectin

2001 • 95 citations

Generation of procoagulant activity by mononuclear phagocytes: a possible mechanism contributing to blood clotting activation within malignant tissues

1983 • 93 citations

Monocyte procoagulant inducing factor: a lymphokine involved in the T cell-instructed monocyte procoagulant response to antigen.

1986 • 83 citations

Preliminary study to identify cancer patients at high risk of venous thrombosis following major surgery

1993 • 82 citations

Platelet-leukocyte-endothelial cell interaction on the blood vessel wall.

1997 • 81 citations

The Effect of Very-low-dose Warfarin on Markers of Hypercoagulation in Metastatic Breast Cancer: Results from a Randomized Trial

1998 • 79 citations

Venous thromboembolism and cancer: a two-way clinical association.

1997 • 79 citations

The role of leukocytes in the activation of blood coagulation.

1992 • 78 citations

P-Selectin-β2-Integrin Cross-Talk: A Molecular Mechanism For Polymorphonuclear Leukocyte Recruitment At The Site Of Vascular Damage

1999 • 77 citations

Chemotherapy enhances endothelial cell reactivity to platelets

1990 • 77 citations

Fibrinolysis and Cancer

1990 • 75 citations

Venous Thromboembolism in Malignancy and Malignancy in Venous Thromboembolism

1998 • 72 citations

Thrombosis in Cancer Patients Treated with Hematopoietic Growth Factors - A Meta-Analysis

1996 • 71 citations

Human tumor procoagulants: registry of the Subcommittee on Haemostasis and Malignancy of the Scientific and Standardization Committee, International Society on Thrombosis and Haemostasis.

1993 • 68 citations

Cancer procoagulant: a factor X activator, tumor marker and growth factor from malignant tissue.

1997 • 65 citations

Guidelines for Clotting Studies in Cancer Patients

1993 • 63 citations

Cancer Procoagulant in Acute Non Lymphoid Leukemia: Relationship of Enzyme Detection to Disease Activity

1990 • 56 citations

Cysteine proteinase procoagulant from amnion-chorion

1985 • 56 citations

Warfarin inhibits both procoagulant activity and metastatic capacity of Lewis Lung Carcinoma cells

1983 • 54 citations

Lectures on Surgical Pathology and Therapeutics: A Handbook for Students and Practitioners

2011 • 53 citations

Enhancement by interleukin-1 (IL-1) of plasminogen activator inhibitor (PA-I) activity in cultured human endothelial cells

1986 • 51 citations

Cancer procoagulant in the human promyelocytic cell line NB4 and its modulation by all-trans-retinoic acid.

1994 • 51 citations

The hypercoagulable state in cancer patients

1994 • 51 citations

Human breast and colon carcinomas express cysteine proteinase activities with pro‐aggregating and pro‐coagulant properties

1988 • 48 citations

Molecular Mechanisms Linking Thrombosis and Angiogenesis in Cancer

1997 • 45 citations

Effects of dimethyl sulfoxide (DMSO) on microfilament organization, cellular adhesion, and growth of cultured mouse B16 melanoma cells

1987 • 45 citations

Warfarin Is Safe as Secondary Prophylaxis in Patients With Cancer and a Previous Episode of Venous Thrombosis

2000 • 42 citations

Venous Thromboembolism as First Manifestation of Cancer

2001 • 41 citations

Cancer procoagulant in acute lymphoblastic leukemia

1990 • 39 citations

Cancer Cell Procoagulants and Their Pharmacological Modulation

1984 • 36 citations

Cancer cell procoagulant: A novel vitamin K-dependent activity

1981 • 29 citations

Induction of monocyte-macrophage procoagulant activity by transformed cell lines.

1986 • 28 citations

10 The importance of blood cell-vessel wall interactions in tumour metastasis

1993 • 28 citations

Altered viscosity and yield stress in patients with abdominal malignancy: Relationship to deep vein thrombosis

1976 • 26 citations

Procoagulant and fibrinolytic activity of human ovarian carcinoma cells in culture

1986 • 24 citations

Macrophages associated with murine tumours express plasminogen activator activity

1988 • 21 citations

Several murine metastasizing tumors possess a cysteine proteinase with cancer procoagulant characteristics

1987 • 19 citations

Procoagulant activity of macrophages associated with different murine neoplasms

1984 • 15 citations

Blood coagulation changes in nude mice bearing human colon carcinomas

1992 • 13 citations

The induction of a hypercoagulable state by medroxyprogesterone acetate in breast cancer patients

1990 • 11 citations

Expression of Plasminogen Activator as a Marker of Stimulation in Tumor-Associated Macrophages

1988 • 10 citations

Plasminogen activator activity of metastatic variants from a murine fibrosarcoma; effect of thrombin in vitro

1983 • 9 citations

Distribution of cardiac output during development of two metastasizing murine tumors

1983 • 9 citations

γ-Glutamyl Carboxylase Activity in Experimental Tumor Tissues: A Biochemical Basis for Vitamin K Dependence of Cancer Procoagulant

1986 • 8 citations

Vitamin K-Dependent Procoagulant in Cancer Cells: A Potential Target for the Antimetastatic Effect of Warfarin?

1986 • 8 citations

Thrombin stimulates arachidonate metabolism in murine tumor cells

1987 • 6 citations