Cell biology of tissue factor, the principal initiator of blood coagulation

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

The coagulation cascade: initiation, maintenance, and regulation

1991 • 1,810 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque.

1989 • 1,233 citations

Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.

1989 • 1,199 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.

1984 • 944 citations

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

1987 • 888 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration.

1990 • 857 citations

C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor

1993 • 809 citations

Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation.

1977 • 791 citations

P-selectin induces the expression of tissue factor on monocytes.

1994 • 595 citations

Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity.

1986 • 592 citations

Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor.

1988 • 561 citations

Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock.

1993 • 552 citations

Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells [published erratum appears in Blood 1990 Dec 1;76(11):2420]

1990 • 540 citations

[Changes under the influence of high pressure of certain properties of myosin, actomyosin and actin].

1960 • 499 citations

Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice.

1994 • 488 citations

The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action

1988 • 482 citations

Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro.

1987 • 467 citations

Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody.

1991 • 428 citations

Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide.

1986 • 415 citations

Activation of human blood coagulation factor XI independent of factor XII.

1991 • 413 citations

Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees.

1994 • 405 citations

Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity

1986 • 404 citations

Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

1992 • 402 citations

The Endotoxin‐induced Coagulant Activity of Human Monocytes

1975 • 382 citations

Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites.

1991 • 373 citations

Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody

1990 • 369 citations

Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis.

1992 • 367 citations

The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity.

1979 • 356 citations

Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis.

1993 • 353 citations

Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture

1989 • 337 citations

Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade

1987 • 318 citations

Increased Tissue Thromboplastin Activity in Monocytes of Patients with Meningococcal Infection: Related to an Unfavourable Prognosis

1983 • 311 citations

Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion.

1985 • 295 citations

Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin.

1989 • 294 citations

Regulation of the tissue factor gene

1995 • 275 citations

Highly Purified Antithrombin III with Heparin Cofactor Activity Prepared by Disc Electrophoresis

1968 • 274 citations

Mechanisms of thrombin generation during surgery and cardiopulmonary bypass [see comments]

1993 • 266 citations

Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection.

1994 • 264 citations

Aspirin Inhibits Nuclear Factor–κB Mobilization and Monocyte Adhesion in Stimulated Human Endothelial Cells

1995 • 260 citations

Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine

1986 • 259 citations

Regulation of endothelial cell coagulant properties

1989 • 255 citations

Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA.

1987 • 251 citations

Immunohistochemical identification of tissue factor in solid tumors

1992 • 244 citations

Purification and properties of human coagulation factor VII.

1980 • 238 citations

Functional tissue factor is entirely cell surface expressed on lipopolysaccharide-stimulated human blood monocytes and a constitutively tissue factor-producing neoplastic cell line.

1989 • 232 citations

Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function

1991 • 228 citations

Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells.

1991 • 228 citations

ACTIVATION OF INTRAGRAFT ENDOTHELIAL AND MONONUCLEAR CELLS DURING DISCORDANT XENOGRAFT REJECTION

1994 • 223 citations

Transcriptional Regulation of Tissue Factor Expression in Human Endothelial Cells

1995 • 219 citations

Crystal structure of the extracellular region of human tissue factor

1994 • 218 citations

Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade

1989 • 217 citations

Structural biology of tissue factor, the initiator of thrombogenesis in vivo ¹

1994 • 217 citations

Abnormalities of blood coagulation in patients with cancer. Mononuclear cell tissue factor generation.

1981 • 212 citations

Expression of tissue factor procoagulant activity: regulation by cytosolic calcium.

1990 • 212 citations

Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor.

1994 • 203 citations

Isolation and characterization of human factor VII. Activation of factor VII by factor Xa.

1981 • 201 citations

Disseminated intravascular coagulation in rabbits induced by administration of endotoxin or tissue factor: effect of anti-tissue factor antibodies and measurement of plasma extrinsic pathway inhibitor activity

1990 • 199 citations

Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies.

1994 • 199 citations

Mechanisms of thrombin generation during surgery and cardiopulmonary bypass [see comments]

1993 • 190 citations

Human tissue factor: cDNA sequence and chromosome localization of the gene

1987 • 189 citations

Procoagulant activity associated with plasma membrane vesicles shed by cultured tumor cells.

1983 • 184 citations

The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester.

1990 • 180 citations

Thrombomodulin, an endothelial anticoagulant protein, is absent from the human brain

1986 • 176 citations

Binding of Human Factor VIIa to Tissue Factor Induces Cytosolic Ca2+ Signals in J82 Cells, Transfected COS-1 Cells, Madin-Darby Canine Kidney Cells and in Human Endothelial Cells Induced to Synthesize Tissue Factor

1995 • 175 citations

Depletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation induced with tissue factor: evidence supporting a physiologic role for EPI as a natural anticoagulant.

1991 • 170 citations

Antibody and immune complexes induce tissue factor production by human endothelial cells.

1986 • 164 citations

Regulation of the Tissue Factor Promoter in Endothelial Cells

1995 • 160 citations

Increased monocyte tissue factor expression in coronary disease.

1995 • 158 citations

Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis.

1993 • 156 citations

A set of inducible genes expressed by activated human monocytic and endothelial cells contain kappa B-like sites that specifically bind c-Rel-p65 heterodimers.

1994 • 155 citations

Determination of plasma tissue factor antigen and its clinical significance

1994 • 154 citations

Tissue factor as a tumor procoagulant

1992 • 152 citations

Cellular cooperation in endothelial cell thromboplastin synthesis

1983 • 152 citations

Endothelial cells stimulated with tumor necrosis factor-alpha express varying amounts of tissue factor resulting in inhomogenous fibrin deposition in a native blood flow system. Effects of thrombin inhibitors.

1994 • 150 citations

Induction of monocyte procoagulant activity by murine hepatitis virus type 3 parallels disease susceptibility in mice.

1981 • 150 citations

Agonist-mediated tissue factor expression in cultured vascular smooth muscle cells. Role of Ca2+ mobilization and protein kinase C activation.

1993 • 150 citations

Induction of endothelial cell tissue factor activity by sera from patients with antiphospholipid syndrome: A possible mechanism of thrombosis

1993 • 148 citations

Tissue factor mRNA in THP-1 monocytic cells is regulated at both transcriptional and posttranscriptional levels in response to lipopolysaccharide.

1991 • 143 citations

Structure of the Extracellular Domain of Human Tissue Factor: Location of the Factor VIIa Binding Site

1994 • 143 citations

Role of the membrane surface in the activation of human coagulation factor X.

1992 • 141 citations

Evidence for the presence of tissue factor activity on subendothelium

1989 • 141 citations

Relations between factor VIIa binding and expression of factor VIIa/tissue factor catalytic activity on cell surfaces.

1992 • 139 citations

Production and availability of thromboplastin in endothelial cells: the effects of thrombin, endotoxin and platelets

1984 • 138 citations

Progestational regulation of human endometrial stromal cell tissue factor expression during decidualization.

1993 • 137 citations

Cell-free pool of CD14 mediates activation of transcription factor NF-kappa B by lipopolysaccharide in human endothelial cells.

1993 • 135 citations

Inhibition of the receptor-mediated endocytosis of diferric transferrin is associated with the covalent modification of the transferrin receptor with palmitic acid.

1990 • 133 citations

Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products.

1993 • 133 citations

A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor.

1989 • 129 citations

Complete Inhibition of Endotoxin-Induced Coagulation Activation in Chimpanzees with a Monoclonal Fab Fragment against Factor VII/VIIa

1995 • 128 citations

Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine

1988 • 126 citations

The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism.

1992 • 125 citations

Assay and Content of Tissue Thromboplastin in Different Organs*

1965 • 124 citations

Activation of blood coagulation in Crohn's disease. Increased plasma fibrinopeptide A levels and enhanced generation of monocyte tissue factor activity.

1987 • 124 citations

The Nembutal Metabolic Rate as an Aid in the Study of Thyroid Function

1957 • 123 citations

Prevention of arterial reocclusion after thrombolysis with recombinant lipoprotein-associated coagulation inhibitor.

1991 • 123 citations

Tissue Factor: Then and Now

1995 • 119 citations

Lipopolysaccharide Induction of Tissue Factor Gene Expression in Monocytic Cells Is Mediated by Binding of c-Rel/p65 Heterodimers to a κB-Like Site

1994 • 118 citations

Murine tissue factor gene expression in vivo. Tissue and cell specificity and regulation by lipopolysaccharide.

1993 • 117 citations

The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes.

1994 • 117 citations

Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor

1992 • 117 citations

The Stimulatory Effect of Platelets and Platelet Membranes on the Procoagulant Activity of Leukocytes

1974 • 116 citations

Factor VII autoactivation proceeds via interaction of distinct protease-cofactor and zymogen-cofactor complexes. Implications of a two-dimensional enzyme kinetic mechanism.

1993 • 112 citations

Expression of tissue factor pathway inhibitor by cultured endothelial cells in response to inflammatory mediators

1992 • 111 citations

Deletion of the membrane anchoring region of tissue factor abolishes autoactivation of factor VII but not cofactor function. Analysis of a mutant with a selective deficiency in activity.

1992 • 111 citations

Palmitoylation of luteinizing hormone/human choriogonadotropin receptors in transfected cells. Abolition of palmitoylation by mutation of Cys-621 and Cys-622 residues in the cytoplasmic tail increases ligand-induced internalization of the receptor.

1994 • 111 citations

Sites of Tissue Factor Pathway Inhibitor (TFPI) and Tissue Factor Expression under Physiologic and Pathologic Conditions

1995 • 111 citations

Tissue factor is expressed on monocytes during simulated extracorporeal circulation.

1993 • 111 citations

Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response.

1991 • 111 citations

cDNA Cloning and mRNA Expression of a Serine Proteinase Inhibitor Secreted by Cancer Cells: Identification as Placental Protein 5 and Tissue Factor Pathway Inhibitor-2

1994 • 111 citations

Immunodepletion of extrinsic pathway inhibitor sensitizes rabbits to endotoxin-induced intravascular coagulation and the generalized Shwartzman reaction

1991 • 110 citations

Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions

1991 • 109 citations

Hepsin, a Putative Membrane-associated Serine Protease, Activates Human Factor VII and Initiates a Pathway of Blood Coagulation on the Cell Surface Leading to Thrombin Formation

1995 • 108 citations

Interleukin‐10 inhibits the induction of monocyte procoagulant activity by bacterial lipopolysaccharide

1993 • 104 citations

A sensitive assay of extrinsic coagulation pathway inhibitor (EPI) in plasma and plasma fractions

1987 • 102 citations

Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa

1993 • 101 citations

Induction of tissue factor on monocytes by adhesion to endothelial cells.

1995 • 99 citations

Tissue Factor: molecular recognition and cofactor function

1995 • 99 citations

Cloning and expression of human tissue factor cDNA

1987 • 98 citations

The evaluation of complex-dependent alterations in human factor VIIa.

1992 • 98 citations

Mechanism of antithrombin III inhibition of factor VIIa/tissue factor activity on cell surfaces. Comparison with tissue factor pathway inhibitor/factor Xa-induced inhibition of factor VIIa/tissue factor activity

1995 • 98 citations

Further link between complement activation and blood coagulation

1977 • 97 citations

Molecular cloning of effector cell protease receptor-1, a novel cell surface receptor for the protease factor Xa.

1994 • 96 citations

Tumor necrosis factor-induced endothelial tissue factor is associated with subendothelial matrix vesicles but is not expressed on the apical surface

1992 • 96 citations

Isolierung und Charakterisierung des Plazenta-Proteins PP5

1977 • 95 citations

Monocyte tissue factor induction by lipopolysaccharide (LPS): dependence on LPS-binding protein and CD14, and inhibition by a recombinant fragment of bactericidal/permeability-increasing protein

1994 • 95 citations

Activation of blood coagulation in Crohn's disease

1987 • 95 citations

The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII

1991 • 94 citations

Thrombin regulates tissue factor and thrombomodulin mRNA levels and activities in human saphenous vein endothelial cells by distinct mechanisms.

1993 • 93 citations

Immunohistochemical detection of tissue factor (TF) on paraffin sections of routinely fixed human tissue

1994 • 91 citations

Lipid association, but not the transmembrane domain, is required for tissue factor activity. Substitution of the transmembrane domain with a phosphatidylinositol anchor.

1991 • 89 citations

Expression of tissue factor pathway inhibitor by cultured endothelial cells in response to inflammatory mediators

1992 • 86 citations

Activation of endothelial cells induces platelet thrombus formation on their matrix. Studies of new in vitro thrombosis model with low molecular weight heparin as anticoagulant.

1990 • 85 citations

CYTOKINE-INDUCED PROCOAGULANT ACTIVITY IN MONOCYTES AND ENDOTHELIAL CELLS FURTHER ENHANCEMENT BY CYCLOSPORINE

1988 • 85 citations

IL‐4 inhibits LPS‐, IL‐1β‐ and TNFα‐induced expression of tissue factor in endothelial cells and monocytes

1992 • 84 citations

Functional analysis of the human tissue factor promoter and induction by serum.

1990 • 84 citations

Purification and some properties of the protein component of tissue thromboplastin from human brain

1977 • 83 citations

Uptake of exogenous free cholesterol induces upregulation of tissue factor expression in human monocyte-derived macrophages.

1992 • 83 citations

Recombinant lipoprotein-associated coagulation inhibitor inhibits tissue thromboplastin-induced intravascular coagulation in the rabbit

1990 • 82 citations

Simultaneous expression of tissue factor and tissue factor pathway inhibitor by human monocytes. A potential mechanism for localized control of blood coagulation.

1994 • 79 citations

IL‐4 and IL‐13 exhibit comparable abilities to reduce pyrogen‐induced expression of procoagulant activity in endothelial cells and monocytes

1993 • 78 citations

Vascular origin of Kaposi's sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor.

1994 • 77 citations

Activation of the host response in human plasmodium falciparum malaria: Relation of parasitemia to tumor necrosis factor/cachectin, thrombin-antithrombin III, and protein C levels

1991 • 75 citations

Tissue Factor Localization in Non-Human Primate Cerebral Tissue

1992 • 75 citations

Expression of tissue factor and tissue factor pathway inhibitor in monocytes in response to bacterial lipopolysaccharide and phorbolester

1994 • 75 citations

Human monocytes support factor X activation by factor VIIa, independent of tissue factor: implications for the therapeutic mechanism of high- dose factor VIIa in hemophilia [see comments]

1994 • 72 citations

Mechanisms of binding of recombinant extrinsic pathway inhibitor (rEPI) to cultured cell surfaces. Evidence that rEPI can bind to and inhibit factor VIIa-tissue factor complexes in the absence of factor Xa.

1992 • 72 citations

Thrombin Induces Thromboplastin Synthesis in Cultured Vascular Endothelial Cells

1985 • 71 citations

Mutational Mapping of Functional Residues in Tissue Factor: Identification of Factor VII Recognition Determinants in Both Structural Modules of the Predicted Cytokine Receptor Homology Domain

1994 • 71 citations

Integrin regulation of an inflammatory effector gene. Direct induction of the tissue factor promoter by engagement of beta 1 or alpha 4 integrin chains.

1995 • 70 citations

Tissue factor: identification and characterization of cell types in human placentae

1990 • 70 citations

Tissue Factor Expression in Human Leukocytes and Tumor Cells

1995 • 69 citations

In vitro stimulation of tissue thromboplastin (factor III) activity in human monocytes by immune complexes and lectins

1979 • 69 citations

Species Specificity of Tissue Thromboplastin

1984 • 69 citations

Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a kappa B-like site.

1994 • 68 citations

IMMUNOHISTOLOGICAL ANALYSIS OF SERIAL BIOPSIES TAKEN DURING HUMAN RENAL ALLOGRAFT REJECTION

1985 • 67 citations

Coagulation assembly on leukocytes in transmembrane signaling and cell adhesion

1993 • 66 citations

Serum stimulation of quiescent human fibroblasts induces the synthesis of tissue factor mRNA followed by the appearance of tissue factor antigen and procoagulant activity

1989 • 66 citations

Inhibition of Extrinsic Pathway Inhibitor Shortens the Coagulation Time of Normal Plasma and of Hemophilia Plasma

1991 • 65 citations

Use of annexin-V to demonstrate the role of phosphatidylserine exposure in the maintenance of haemostatic balance by endothelial cells

1992 • 62 citations

High Affinity Ca2+-binding Site in the Serine Protease Domain of Human Factor VIIa and Its Role in Tissue Factor Binding and Development of Catalytic Activity

1995 • 61 citations

Cloning of murine tissue factor and regulation of gene expression by transforming growth factor type beta 1.

1991 • 60 citations

The biochemical basis for the apparent defect of soluble mutant tissue factor in enhancing the proteolytic activities of factor VIIa.

1994 • 60 citations

Elevated plasma tissue factor antigen level in patients with disseminated intravascular coagulation

1994 • 60 citations

Advances in Cardiovascular Engineering

1992 • 59 citations

Interleukin‐10 inhibits endotoxin‐induced tissue factor mRNA production by human monocytes

1993 • 58 citations

Progestational regulation of human endometrial stromal cell tissue factor expression during decidualization

1993 • 58 citations

Regulation of human tissue factor expression by mRNA turnover.

1993 • 58 citations

Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers

1994 • 58 citations

Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding

1989 • 57 citations

von Willebrand factor release and thrombomodulin and tissue factor expression in Rickettsia conorii-infected endothelial cells

1992 • 56 citations

Enhanced procoagulatory activity (PCA) of human monocytes/macrophages after in vitro stimulation with chemically modified LDL

1989 • 56 citations

Factor XII-independent activation of factor XI in plasma: effects of sulfatides on tissue factor-induced coagulation

1993 • 55 citations

Fibroblast tissue factor: calcium and ionophore induce shape changes, release of membrane vesicles, and redistribution of tissue factor antigen in addition to increased procoagulant activity

1994 • 55 citations

Activation of the coagulation mechanism on tumor necrosis factor-stimulated cultured endothelial cells and their extracellular matrix. The role of flow and factor IX/IXa

1991 • 55 citations

Conservation of tissue factor primary sequence among three mammalian species

1991 • 54 citations

Role of the lipopolysaccharide (LPS)-binding protein/CD14 pathway in LPS induction of tissue factor expression in monocytic cells.

1994 • 54 citations

Phorbol esters induce synthesis of thromboplastin activity in human monocytes

1981 • 53 citations

Tumor necrosis factor alpha-induced endothelial tissue factor is located on the cell surface rather than in the subendothelial matrix

1994 • 53 citations

Generation and characterization of hamster-mouse hybridomas secreting monoclonal antibodies with specificity for lipopolysaccharide receptor.

1990 • 53 citations

Monocyte procoagulant activity in glomerulonephritis associated with systemic lupus erythematosus.

1985 • 52 citations

Endotoxin-Induced Tissue Factor in Human Monocytes is Dependent upon Protein Kinase C Activation

1993 • 51 citations

Positive and Negative Regulation of Transcription and Cell Growth Mediated by the EGR Family of Zinc‐Finger Gene Products^a

1993 • 51 citations

Beitrage zur Kenntnis der Blutgerinnung

1948 • 51 citations

Pyrrolidine dithiocarbamate abrogates tissue factor (TF) expression by endothelial cells: evidence implicating nuclear factor-kappa B in TF induction by diverse agonists

1995 • 50 citations

Mammalian cell transient expression of tissue factor for the production of antigen

1990 • 50 citations

Hypoxia induces procoagulant activity in cultured human venous endothelium

1991 • 50 citations

Rickettsia rickettsii infection of cultured human endothelial cells induces tissue factor expression

1994 • 50 citations

Antibody mapping of tissue factor implicates two different exon-encoded regions in function

1991 • 49 citations

The stable prostacyclin analog, iloprost, and prostaglandin E1 inhibit monocyte procoagulant activity in vitro

1991 • 49 citations

The effect of two-domain tissue factor pathway inhibitor on endotoxin-induced disseminated intravascular coagulation in rabbits

1993 • 48 citations

Immunoelectron microscopic localization of type 1 plasminogen activator inhibitor on the surface of activated endothelial cells.

1991 • 48 citations

Prevention of Thrombosis by Topical Application of Tissue Factor Pathway Inhibitor in a Rabbit Model of Vascular Trauma

1993 • 47 citations

Key ligand interface residues in tissue factor contribute independently to factor VIIa binding.

1994 • 47 citations

Inhibition of human factor VIIIa-tissue factor activity by placental anticoagulant protein

1987 • 47 citations

Endotoxin-induced tissue factor messenger RNA in human monocytes is negatively regulated by a cyclic AMP-dependent mechanism

1993 • 47 citations

Retinoic acid reduces induction of monocyte tissue factor and tissue factor/factor VIIa-dependent arterial thrombus formation

1995 • 47 citations

Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function

1991 • 45 citations

Potential Role of Protease Nexin‐2/Amyloid β‐Protein Precursor as a Cerebral Anticoagulant^a

1992 • 45 citations

Activated factor X and thrombin formation triggered by tissue factor on endothelial cell matrix in a flow model: effect of the tissue factor pathway inhibitor

1994 • 44 citations

Polar expression of tissue factor in human umbilical vein endothelial cells.

1994 • 44 citations

The effects of shear rate on the enzymatic activity of the tissue factor-factor VIIa complex

1990 • 44 citations

Self-association of tissue factor as revealed by chemical crosslinking.

1991 • 43 citations

Antithrombotic effect of recombinant truncated tissue factor pathway inhibitor (TFPI1-161) in experimental venous thrombosis--a comparison with low molecular weight heparin.

1994 • 43 citations

Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa.

1991 • 42 citations

Effect of some drugs on thromboplastin (factor III) activity of human monocytes in vitro

1980 • 40 citations

Lack of suppressed renal thrombomodulin expression in a septic rat model with glomerular thrombotic microangiopathy.

1994 • 40 citations

Endotoxin-induced tissue factor messenger RNA in human monocytes is negatively regulated by a cyclic AMP-dependent mechanism

1993 • 40 citations

Tissue factor potentiates the factor VIIa-catalyzed hydrolysis of an ester substrate.

1992 • 40 citations

Role of cyclic AMP in promoting the thromboresistance of human endothelial cells by enhancing thrombomodulin and decreasing tissue factor activities

1993 • 39 citations

Regulation of tissue factor gene expression in epithelial cells. Induction by serum and phorbol 12-myristate 13-acetate.

1994 • 39 citations

Immunohistological detection of tissue factor in normal and abnormal human mammary glands using monoclonal antibodies

1992 • 38 citations

Circulating Tissue Thromboplastin during Hip Surgery

1979 • 38 citations

Tissue factor in plasma of patients with disseminated intravascular coagulation

1994 • 38 citations

Humic Acid Induces Expression of Tissue Factor by Cultured Endothelial Cells: Regulation by Cytosolic Calcium and Protein Kinase C

1994 • 37 citations

Identification of the Factor VIIa Binding Site on Tissue Factor by Homologous Loop Swap and Alanine Scanning Mutagenesis

1994 • 36 citations

Relationship between Endothelial Tissue Factor and Thrombogenesis under Blood Flow Conditions

1995 • 36 citations

Interleukin‐10 and pentoxifylline inhibit C‐reactive protein‐induced tissue factor gene expression in peripheral human blood monocytes

1994 • 35 citations

Factor VIIa/tissue factor-catalyzed activation of factors IX and X on a cell surface and in suspension: a kinetic study.

1992 • 35 citations

Flow chambers and their standardization for use in studies of thrombosis. On behalf of the Subcommittee on Rheology of the Scientific and Standardization Committee of the ISTH.

1994 • 34 citations

Copper-Induced Tissue Factor Expression in Human Monocytic THP-1 Cells and Its Inhibition by Antioxidants

1995 • 34 citations

Thromboplastin (tissue factor) in plasma membranes of human monocytes

1985 • 33 citations

Monocyte tissue factor induction by lipopolysaccharide (LPS): dependence on LPS-binding protein and CD14, and inhibition by a recombinant fragment of bactericidal/permeability-increasing protein

1994 • 33 citations

Post-translational modifications of recombinant human tissue factor

1990 • 32 citations

Interleukin 4 prevents the induction of tissue factor mRNA in human monocytes in response to LPS or PMA stimulation

1993 • 32 citations

Extrinsic pathway inhibitor (EPI) and the post-heparin anticoagulant effect in tissue thromboplastin induced coagulation

1991 • 31 citations

Refractory period phenomenon in the induction of tissue factor expression on endothelial cells

1991 • 31 citations

Efficient gene transfer into human umbilical vein endothelial cells allows functional analysis of the human tissue factor gene promoter

1994 • 31 citations

Is Tissue Factor Pathway Inhibitor Involved in the Antithrombotic Effect of Heparins?

1993 • 30 citations

Activation of factor X and its regulation by tissue factor pathway inhibitor in small-diameter capillaries lined with human endothelial cells

1992 • 29 citations

Platelets Stimulate Thromboplastin Synthesis in Human Endothelial Cells

1983 • 29 citations

Lipopolysaccharide induction of tissue factor expression in THP-1 monocytic cells. Protein-DNA interactions with the promoter.

1994 • 29 citations

Factor Vlla/Tissue Factor-Catalyzed Activation of Factors IX and X on a Cell Surface and in Suspension: A Kinetic Study

1992 • 28 citations

Flow Chambers and their Standardization for Use in Studies of Thrombosis

1994 • 28 citations

Pentoxifylline Inhibition of Procoagulant Activity Generated by Activated Mononuclear Phagocytes

2015 • 28 citations

Urinary Tissue Factor Levels in Prostatic Carcinoma: A Potential. Marker of Metastatic Spread ?

1993 • 28 citations

An unusual antibody that blocks tissue factor/factor VIIa function by inhibiting cleavage only of macromolecular substrates

1992 • 28 citations

Chelerythrine, a selective protein kinase C inhibitor, counteracts pyrogen-induced expression of tissue factor without effect on thrombomodulin down-regulation in endothelial cells

1993 • 27 citations

The Effect of Interleukin-4 on Tumour Necrosis Factor-Alpha Induced Expression of Tissue Factor and Plasminogen Activator Inhibitor-1 in Human Umbilical Vein Endothelial Cells

1993 • 27 citations

Protein Tyrosine Kinase Activation Is Required for LPS and PMA Induction of Tissue Factor mRNA in Human Blood Monocytes

1995 • 26 citations

Ex Vivo Models for Studying Thrombosis: Special Emphasis on Shear Rate Dependent Blood-Collagen Interactions

1992 • 26 citations

Structure of the murine tissue factor gene. Chromosome location and conservation of regulatory elements in the promoter.

1992 • 26 citations

Monocyte procoagulant activity in breast cancer

1987 • 25 citations

Inflammatory particles stimulate thromboplastin production by human monocytes

1983 • 24 citations

Localization of Tissue Thromboplastin in the Human Brain

1977 • 24 citations

Dipyridamole inhibits O2− release and expression of tissue factor activity by peripheral blood monocytes stimulated with lipopolysaccharide

1990 • 24 citations

Induction of Tissue Factor Synthesis in Human Umbilical Vein Endothelial Cells Involves Protein Kinase C

1992 • 23 citations

Pentoxifylline inhibits the expression of tissue factor mRNA in endotoxin‐activated human monocytes

1993 • 21 citations

Dipyridamole stimulates urokinase production and suppresses procoagulant activity of rabbit alveolar macrophages: a possible mechanism of antithrombotic action

1987 • 21 citations

Lack of ability to synthesize tissue factor by endothelial cells in intact human saphenous veins.

1990 • 21 citations

Dipyridamole stimulates urokinase production and suppresses procoagulant activity of rabbit alveolar macrophages: a possible mechanism of antithrombotic action

1987 • 21 citations

Modulation of procoagulant activity of extracellular endothelial matrix by anti-tissue factor antibody and the synthetic peptide Arg-Gly-Asp-Val. Experiments with flowing nonanticoagulated human blood

1993 • 21 citations

Lectin Stimulation of Tissue Thromboplastin Activity in Human Monocytes in vitro

1979 • 21 citations

Role of tissue factor pathway inhibitor in post surgical deep venous thrombosis (DVT) prophylaxis in patients treated with low molecular weight heparin

1994 • 21 citations

Utilization of a continuous flow reactor to study the lipoprotein- associated coagulation inhibitor (LACI) that inhibits tissue factor

1990 • 20 citations

Thromboplastin Synthesis in Endothelial Cells

1984 • 20 citations

Effect of Cyclic AMP and Cyclic GMP on Thromboplastin (Factor III) Synthesis in Human Monocytes In Vitro

1983 • 20 citations

cDNA and amino acid sequences of bovine tissue factor

1991 • 19 citations

An Immunoradiometric Assay for Factor III (Tissue Thromboplastin)

1978 • 19 citations

Differential Diagnosis of Hematologic and Solid Tumors Using Targeted Transcriptome and Artificial Intelligence

2022 • 19 citations

Regulation of factor VIIa/tissue factor functional activity in an umbilical vein model.

1993 • 19 citations

Antiparasitic Treatment of Patients with P. falciparum Malaria Reduces the Ability of Patient Serum to Induce Tissue Factor by Decreasing NF-κB Activation

1995 • 18 citations

Induction of tissue factor activity in endothelial cells and monocytes by a modified form of albumin present in normal human plasma

1992 • 18 citations

LPS-induced, but not interferon-gamma-induced procoagulant activity of suspended human macrophages is followed by a refractory state of low procoagulant expression

1992 • 18 citations

Effect of purified protein derivative and sonicates of Mycobacterium leprae and Mycobacterium bovis BCG on thromboplastin response in human monocytes in vitro

1982 • 17 citations

Thromboplastin release, but not content, correlates with spontaneous metastasis of cancer cells

1988 • 17 citations

Platelet-activating factor modulates endotoxin-induced macrophage procoagulant activity by a protein kinase C-dependent mechanism

1992 • 17 citations

Effect of repeated Aprosulate?? and Enoxaparin?? administration on tissue factor pathway inhibitor antigen levels

1995 • 16 citations

Two Independent Binding Sites on Monolayers of Human Endothelial Cells Are Responsible for Interaction with Coagulation Factor VII and Factor VIIa

1993 • 16 citations

Non-tissue factor procoagulants in cancer cells

1992 • 16 citations

Structural requirements for the interaction between tissue factor and factor VII: characterization of chymotrypsin-derived tissue factor polypeptides

1993 • 15 citations

Tissue factor antigen and activity are not expressed on the surface of intact cells isolated from an acute promyelocytic leukemia patient

1990 • 15 citations

Characterization of the interactions between procoagulant albumin and human endothelial cells

1993 • 15 citations

Signal transduction pathways of bacterial lipopolysaccharide-stimulated bovine vascular endothelial cells

1994 • 14 citations

Molecular Cloning, Characterization and Expression of cDNA for Rabbit Brain Tissue Factor

1991 • 12 citations

Measurements of tissue factor-like activity in plasma of patients with DIC

1991 • 12 citations

Tissue factor pathway inhibitor (TFPI) and its response to heparin in patients with spontaneous deep vein thrombosis

1993 • 11 citations

K ⁺ Channel Blockers Inhibit Tissue Factor Expression by Human Monocytic Cells

1995 • 11 citations

Inhibition of procoagulant activity of human monocytes by chenodeoxycholic acid: Involvement of protein kinase C

1994 • 11 citations

Allogenic induction of thromboplastin synthesis in monocytes and endothelial cells. Biphasic effect of cyclosporin A.

1989 • 10 citations

Chemical Cross-Linking of Activated Coagulation Factor VII with Soluble Tissue Factor: Calcium Ions Are Not Essential for Full Amidolytic Activity of the Factor VIIa-Tissue Factor Complex after Complex Formation1

1995 • 10 citations

Tuftsin induces tissue factor-like activity in human mononuclear cells and in monocytic cell lines

1990 • 9 citations

Identification and mapping of RFLPs for human tissue factor (HTF) to chromosome 1p

1987 • 7 citations

Factors Affecting the lnteraction of Tissue Factor/Factor Vll with Factor X in a Heterogeneous Tubular Reactor

1991 • 7 citations

Amines Induce Increased Thromboplastin Activity in Human Monocytes

1983 • 6 citations

Staurosporine blocks down-regulation of monocyte-associated tissue factor

1994 • 5 citations

The regulation of uterine tissue factor by estrogen

1995 • 5 citations

The function of granulocytes and alveolar macrophages following a single dose of endotoxin in rabbits. Effects of methylprednisolone

1990 • 4 citations

Deleted Work

1955 • 0 citations