Dimerization and activation of the common transducing chain (gp130) of the cytokines of the IL-6 family by mAb.

Interleukin-6 family of cytokines and gp130

1995 • 1,314 citations

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

1996 • 635 citations

Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma

1994 • 293 citations

Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells

1996 • 96 citations

Interleukin‐6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti‐gp130 monoclonal antibodies

1995 • 87 citations

Homodimerization of Erythropoietin Receptor by a Bivalent Monoclonal Antibody Triggers Cell Proliferation and Differentiation of Erythroid Precursors

1997 • 83 citations

Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines.

1997 • 73 citations

Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M

1996 • 34 citations

gp130 Transducing Receptor Cross-linking Is Sufficient to Induce Interleukin-6 Type Responses

1996 • 25 citations

Epitope analysis of human IL-6 receptor gp80 molecule with monoclonal antibodies.

1994 • 17 citations

Activation of the gp130 signaling pathway by monoclonal antibodies directed against the gp130 molecule

1997 • 9 citations