The Interaction of Specific Peptide Aptamers With the DNA Binding Domain and the Dimerization Domain of the Transcription Factor Stat3 Inhibits Transactivation and Induces Apoptosis in Tumor Cells

The Hallmarks of Cancer

2000 • 27,569 citations

STATs and Gene Regulation

1997 • 3,927 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

STATs: transcriptional control and biological impact

2002 • 3,050 citations

Stat3 as an Oncogene

1999 • 2,770 citations

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

1999 • 2,410 citations

NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer

2000 • 2,394 citations

STATs in oncogenesis

2000 • 1,723 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Arginine-rich Peptides

2001 • 1,582 citations

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters

2000 • 1,549 citations

Mechanisms of Apoptosis

2000 • 1,249 citations

The role of STATs in transcriptional control and their impact on cellular function

2000 • 1,186 citations

Transcription factors as targets for cancer therapy

2002 • 1,147 citations

Bcl-2 family proteins

1998 • 1,055 citations

Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

2002 • 1,027 citations

Cellular stress response and apoptosis in cancer therapy

2001 • 793 citations

Three-dimensional structure of the Stat3β homodimer bound to DNA

1998 • 769 citations

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

2001 • 751 citations

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

2002 • 739 citations

Inhibiting the p53–MDM2 interaction: an important target for cancer therapy

2003 • 704 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

The CD95 (APO-1/Fas) and the TRAIL (APO-2L) Apoptosis Systems

2000 • 625 citations

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

2001 • 617 citations

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

2003 • 562 citations

The role of proteases during apoptosis

1996 • 558 citations

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

2001 • 546 citations

Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

2003 • 540 citations

Issues and progress with protein kinase inhibitors for cancer treatment

2003 • 529 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA

2000 • 456 citations

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

2001 • 445 citations

Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2

1996 • 444 citations

Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation

2001 • 436 citations

In VivoDelivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis

2002 • 418 citations

Chemotherapy: targeting the mitochondrial cell death pathway

2002 • 396 citations

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

1997 • 370 citations

A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease

2002 • 367 citations

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

1999 • 315 citations

Cooperation between STAT3 and c-Jun Suppresses Fas Transcription

2001 • 248 citations

A proapoptotic peptide for the treatment of solid tumors.

2001 • 245 citations

c-Src, Receptor Tyrosine Kinases, and Human Cancer

1999 • 244 citations

Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

2000 • 238 citations

Tyrosine kinases as targets in cancer therapy – successes and failures

2003 • 223 citations

Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis.

1995 • 220 citations

Death receptors and melanoma resistance to apoptosis

2003 • 210 citations

Protection against ischemic brain injury by protein therapeutics

2002 • 196 citations

Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6

1997 • 146 citations

Quantitation of the Tumor-Targeting Properties of Antibody Fragments Conjugated to Cell-Permeating HIV-1 TAT Peptides

2002 • 133 citations

Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.

2001 • 127 citations

Identification of a High-Affinity Phosphopeptide Inhibitor of Stat3

2003 • 127 citations

Constrained peptides as binding entities

1995 • 121 citations

An artificial cell-cycle inhibitor isolated from a combinatorial library

1998 • 111 citations

Tyrosine kinases as targets for cancer therapy

2002 • 101 citations

Induction of apoptosis in lung-cancer cells followingbcl-xL anti-sense treatment

2000 • 96 citations

Sequence-specific Peptide Aptamers, Interacting with the Intracellular Domain of the Epidermal Growth Factor Receptor, Interfere with Stat3 Activation and Inhibit the Growth of Tumor Cells

2003 • 88 citations

Peptide aptamers targeting the hepatitis B virus core protein: a new class of molecules with antiviral activity

2001 • 84 citations

Targeting cyclin-dependent kinases in Drosophila with peptide aptamers

1998 • 84 citations

Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity

1999 • 84 citations

Selective Inhibition of Growth Factor-stimulated Mitogenesis by a Cell-permeable Grb2-binding Peptide

1997 • 74 citations

Protein Therapy: In Vivo Protein Transduction by Polyarginine (11R) PTD and Subcellular Targeting Delivery

2003 • 73 citations

Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1

1997 • 70 citations

bcl-xl antisense treatment induces apoptosis in breast carcinoma cells

2000 • 67 citations

Centrin in the photoreceptor cells of mammalian retinae

1995 • 63 citations

Suppression of metastasis formation by a recombinant single chain antibody-toxin targeted to full-length and oncogenic variant EGF receptors

1999 • 59 citations

Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene product

2002 • 54 citations

Peptide aptamers: powerful new tools for molecular medicine

2000 • 52 citations

Induction of apoptosis in cervical carcinoma cells by peptide aptamers that bind to the HPV‐16 E7 oncoprotein

2001 • 48 citations

Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells.

2001 • 46 citations

Peptides as New Inhibitors of HIV-1 Reverse Transcriptase and Integrase

2003 • 26 citations

Peptide aptamers: new tools to study protein interactions

2001 • 17 citations