Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Immunisation against heterologous type II collagen induces arthritis in mice

1980 • 1,025 citations

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

1992 • 1,002 citations

Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease

1989 • 870 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

1987 • 847 citations

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.

1989 • 844 citations

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

1993 • 827 citations

Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis

1988 • 793 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).

1985 • 679 citations

IgG1 plasmacytosis in interleukin 6 transgenic mice.

1989 • 597 citations

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.

1988 • 537 citations

Recombinant human interleukin‐6 (IL‐6/BSF‐2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

1988 • 458 citations

Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro.

1989 • 430 citations

Interleukin-6 is a potent thrombopoietic factor in vivo in mice

1989 • 422 citations

Involvement of IL-6 in mesangial proliferative glomerulonephritis.

1989 • 415 citations

B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes.

1988 • 382 citations

IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells.

1988 • 365 citations

B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells.

1987 • 357 citations

Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity.

1993 • 337 citations

Interleukin-6 as a new indicator of inflammatory status: detection of serum levels of interleukin-6 and C-reactive protein after surgery.

1992 • 336 citations

Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1 alpha

1988 • 331 citations

Recombinant human B cell stimulatory factor 2 (BSF‐2/IFN‐β2) regulates β‐fibrinogen and albumin mRNA levels in Fao‐9 cells

1987 • 299 citations

Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis in mice.

1993 • 298 citations

Regulation of very primitive, multipotent, hemopoietic cells by hemopoietin-1

1986 • 283 citations

In vivo effects of recombinant human interleukin-6 in primates: stimulated production of platelets

1990 • 280 citations

Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody.

1993 • 278 citations

Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth.

1993 • 269 citations

Autoimmunity - A Perspective

1983 • 260 citations

Collagen arthritis as a relevant model for rheumatoid arthritis. evidence pro and con

1982 • 256 citations

Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis

1996 • 255 citations

Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment

1994 • 251 citations

Anti-Tumor Necrosis Factor-α Therapy of Rheumatoid Arthritis

1997 • 233 citations

Induction of proliferation and Ig production in human B leukemic cells by anti-immunoglobulins and T cell factors.

1982 • 201 citations

Human T cell activation with phytohemagglutinin. The function of IL-6 as an accessory signal.

1988 • 193 citations

Elevation of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical operation

1989 • 172 citations

Synergism of BSF-2/interleukin 6 and interleukin 3 on development of multipotential hemopoietic progenitors in serum-free culture.

1988 • 165 citations

Stimulation of thrombopoiesis in mice by human recombinant interleukin 6.

1990 • 151 citations

Purification and NH2-terminal sequence of a plasmacytoma growth factor derived from the murine macrophage cell line P388D1.

1987 • 145 citations

Experimental arthritis in a nonhuman primate. I. Induction by bovine type II collagen.

1986 • 139 citations

Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis

1993 • 128 citations

Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines

1987 • 108 citations

Induction of arthritis in monkeys by immunization with type II collagen.

1988 • 96 citations

Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6.

1988 • 90 citations

In vivo direct gene transfer into articular cartilage by intraarticular injection mediated by HVJ (Sendai virus) and liposomes

1997 • 85 citations

Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression.

1991 • 83 citations

Interleukin 6 and expression of its receptor on epidermal keratinocytes

1990 • 82 citations

Enhanced production of interleukin‐6 in mice with type II collagen–induced arthritis

1989 • 73 citations

Collagen‐induced arthritis in an outbred group of rhesus monkeys comprising responder and nonresponder animals. Relationship between the course of arthritis and collagen‐specific immunity

1991 • 48 citations

Interleukin-6 enhances murine megakaryocytopoiesis in serum-free culture

1990 • 46 citations

Urinary IL-6: a marker for mesangial proliferative glomerulonephritis?

1991 • 42 citations

Sex‐Linked differences in susceptibility of cynomolgus monkeys to type II collagen–induced arthritis. Evidence that epitope‐specific immune suppression is involved in the regulation of type II collagen autoantibody formation

1989 • 37 citations

Enhanced expression of interleukin 6 in rat and murine arthritis models

1993 • 35 citations

Experimental arthropathy induced in rhesus monkeys (Macaca mulatta) by intradermal immunization with native bovine type II collagen.

1987 • 29 citations

Case report: Interleukin‐6 positive follicular hyperplasia in the lymph node of a patient with rheumatoid arthritis

1991 • 9 citations