Gene profiling of a myeloma cell line reveals similarities and unique signatures among IL-6 response, N-ras-activating mutations, and coculture with bone marrow stromal cells

The polycomb group protein EZH2 is involved in progression of prostate cancer

2002 • 2,600 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

1999 • 850 citations

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.

1988 • 791 citations

Bone marrow angiogenesis and progression in multiple myeloma

1994 • 656 citations

Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells

2002 • 655 citations

Bone Marrow Neovascularization, Plasma Cell Angiogenic Potential, and Matrix Metalloproteinase-2 Secretion Parallel Progression of Human Multiple Myeloma

1999 • 590 citations

Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion

1993 • 437 citations

IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.

1997 • 416 citations

Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma

2000 • 397 citations

The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases

1996 • 385 citations

Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

1996 • 229 citations

Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease

2001 • 214 citations

Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease

2001 • 188 citations

Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell development

2003 • 170 citations

Abnormalities of bone marrow mesenchymal cells in multiple myeloma patients

2001 • 115 citations

Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6.

1995 • 99 citations

The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA.

1996 • 82 citations

Activating mutations in the N- and K-ras oncogenes differentially affect the growth properties of the IL-6-dependent myeloma cell line ANBL6.

1997 • 59 citations

The bone marrow stromal microenvironment influences myeloma therapeutic response in vitro

2001 • 58 citations

Oncogenes in multiple myeloma: point mutation of N-ras.

1990 • 52 citations

Heterogeneity in therapeutic response of genetically altered myeloma cell lines to interleukin 6, dexamethasone, doxorubicin, and melphalan

2000 • 49 citations

Activation of N-ras and K-ras induced by interleukin-6 in a myeloma cell line: implications for disease progression and therapeutic response

2002 • 40 citations

Bone Marrow Microenvironment and the Progression of Multiple Myeloma

1992 • 37 citations