IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

Tubulointerstitial Changes as a Major Determinant in the Progression of Renal Damage

1992 • 951 citations

Interleukin 15: biology and relevance to human disease

2001 • 947 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

RANTES and Monocyte Chemoattractant Protein–1 (MCP-1) Play an Important Role in the Inflammatory Phase of Crescentic Nephritis, but Only MCP-1 Is Involved in Crescent Formation and Interstitial Fibrosis

1997 • 498 citations

The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis

1996 • 492 citations

Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)

2001 • 444 citations

Interleukin-15 protects from lethal apoptosis in vivo

1997 • 339 citations

IL-15 and IL-2: a matter of life and death for T cells in vivo

2001 • 316 citations

Monocyte Chemoattractant Protein 1–Dependent Leukocytic Infiltrates Are Responsible for Autoimmune Disease in Mrl-Faslpr Mice

1999 • 307 citations

Obstructive uropathy in the mouse: Role of osteopontin in interstitial fibrosis and apoptosis

1999 • 286 citations

Resistance of Fc receptor- deficient mice to fatal glomerulonephritis.

1998 • 271 citations

Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis

1999 • 265 citations

Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis

1999 • 253 citations

Differential effects of interleukin-15 (IL-15) and IL-2 on human neutrophils: modulation of phagocytosis, cytoskeleton rearrangement, gene expression, and apoptosis by IL-15

1996 • 237 citations

Inhibition of Keratinocyte Apoptosis by IL-15: A New Parameter in the Pathogenesis of Psoriasis?

2000 • 209 citations

Soluble IL-15 Receptor α-Chain Administration Prevents Murine Collagen-Induced Arthritis: A Role for IL-15 in Development of Antigen-Induced Immunopathology

1998 • 206 citations

IFN-γ Receptor Signaling Is Essential for the Initiation, Acceleration, and Destruction of Autoimmune Kidney Disease in MRL-FaslprMice

1998 • 202 citations

The Consequences of Tubulo-Interstitial Changes for Renal Function in Glomerulopathies

1990 • 196 citations

Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis

1999 • 167 citations

Death deflected: IL‐15 inhibits TNF‐α‐mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL‐15Rα chain

1999 • 155 citations

Stimulated kidney tubular epithelial cells express membrane associated and secreted TNFα

1991 • 151 citations

Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells.

1996 • 139 citations

Chemotactic factors and renal inflammation

1998 • 135 citations

Expression of apoptosis regulatory proteins in tubular epithelium stressed in culture or following acute renal failure

2000 • 133 citations

Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis

1999 • 125 citations

Targeting the IL-15 Receptor with an Antagonist IL-15 Mutant/Fcγ2a Protein Blocks Delayed-Type Hypersensitivity

1998 • 125 citations

P-selectin deficiency exacerbates experimental glomerulonephritis: a protective role for endothelial P-selectin in inflammation

1999 • 124 citations

INTRAGRAFT IL-15 TRANSCRIPTS ARE INCREASED IN HUMAN RENAL ALLOGRAFT REJECTION1

1996 • 117 citations

Blockade of Antibody-Induced Glomerulonephritis with Crry-Ig, a Soluble Murine Complement Inhibitor

1998 • 109 citations

Is the proximal tubular cell a proinflammatory cell?

2000 • 99 citations

A role for P selectin in complement-independent neutrophil-mediated glomerular injury

1994 • 98 citations

The Sushi Domain of Soluble IL-15 Receptor α Is Essential for Binding IL-15 and Inhibiting Inflammatory and Allogenic Responses In Vitro and In Vivo

2001 • 96 citations

Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice

1996 • 86 citations

Gene transfer of RANTES elicits autoimmune renal injury in MRL-Faslpr mice

1998 • 86 citations

Selective Blockade of IL-15 by Soluble IL-15 Receptor α-Chain Enhances Cardiac Allograft Survival

2000 • 83 citations

Interleukin-15 Prevents Mouse Mast Cell Apoptosis through STAT6-mediated Bcl-xL Expression

2001 • 80 citations

Quiescence-Inducing and Antiapoptotic Activities of IL-15 Enhance Secondary CD4+ T Cell Responsiveness to Antigen

1998 • 79 citations

Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria

1998 • 79 citations

Macrophage Growth Factors Introduced into the Kidney Initiate Renal Injury

1996 • 69 citations

IL-12 Drives IFN-γ-Dependent Autoimmune Kidney Disease in MRL-FaslprMice

1999 • 67 citations

Aminopeptidase A: A nephritogenic target antigen of nephrotoxic serum

2001 • 53 citations

Interleukin-15, a leukocyte activator and growth factor, is produced by cortical tubular epithelial cells.

1998 • 51 citations

TNF-alpha enhances colony-stimulating factor-1-induced macrophage accumulation in autoimmune renal disease.

1996 • 41 citations

Systemic autoimmune nephritogenic components induce CSF-1 and TNF-α in MRL kidneys

1997 • 38 citations

Cytokine cross-talk between tubular epithelial cells and interstitial immunocompetent cells

2001 • 34 citations

IFN-γ Limits Macrophage Expansion in MRL-FaslprAutoimmune Interstitial Nephritis: A Negative Regulatory Pathway

1998 • 28 citations

Interleukin‐15 strongly inhibits interleukin‐8 and monocyte chemoattractant protein‐1 production in human colonic epithelial cells

1999 • 22 citations