Identification of Isoforms of G Proteins and PKC that Colocalize with Tight Junctions

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

The structure, expression, and properties of additional members of the protein kinase C family.

1988 • 706 citations

Structure, biochemistry, and assembly of epithelial tight junctions

1987 • 532 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

Structure, function, and regulation of cellular tight junctions

1992 • 517 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

Cingulin, a new peripheral component of tight junctions

1988 • 505 citations

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes

1992 • 441 citations

Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.

1989 • 374 citations

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

1987 • 356 citations

Activation and depalmitoylation of Gsα

1994 • 336 citations

Growth of Madin-Darby canine kidney epithelial cell (MDCK) line in hormone-supplemented, serum-free medium.

1979 • 306 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

Effect of phorbol esters on protein kinase C-zeta.

1992 • 282 citations

Assembly and sealing of tight junctions: Possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin

1991 • 280 citations

G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits.

1991 • 250 citations

Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid.

1988 • 239 citations

Unique substrate specificity and regulatory properties of PKC‐ε: a rationale for diversity

1989 • 226 citations

Splice Variants of the α Subunit of the G Protein G _s Activate Both Adenylyl Cyclase and Calcium Channels

1989 • 225 citations

Differential Down-regulation of Protein Kinase C Isozymes

1989 • 219 citations

A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization.

1989 • 211 citations

Ca(2+)-independent isoforms of protein kinase C differentially translocate in smooth muscle

1992 • 185 citations

Tumor promoter-induced changes in the permeability of epithelial cell tight junctions

1981 • 185 citations

Receptor and effector interactions of G_s Functional studies with antibodies to the α_s carboxyl‐terminal decapeptide

1989 • 176 citations

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.

1993 • 176 citations

Identification of the GTP-binding protein encoded by Gi3 complementary DNA.

1988 • 169 citations

Effects of tumor promoters on LLC-PK1 renal epithelial tight junctions and transepithelial fluxes

1986 • 163 citations

The role of phosphorylation in development of tight junctions in cultured renal epithelial (MDCK) cells

1991 • 90 citations

Monoclonal antibodies specific for type 3 protein kinase C recognize distinct domains of protein kinase C and inhibit in vitro functional activity.

1988 • 83 citations

Effect of tumour-promoting phorbol ester, thrombin and vasopressin on translocation of three distinct protein kinase C isoforms in human platelets and regulation by calcium

1992 • 57 citations

Molecular cloning of a Drosophila diacylglycerol kinase gene that is expressed in the nervous system and muscle.

1992 • 50 citations

ζ-Related protein kinase C in nuclei of nerve cells

1990 • 46 citations