Alpha Interferon and Gamma Interferon Stimulate Transcription of a Single Gene through Different Signal Transduction Pathways

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

1980 • 1,884 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

Molecular cloning of gene sequences regulated by platelet-derived growth factor

1983 • 989 citations

γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

1985 • 949 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

1987 • 888 citations

Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription

1986 • 761 citations

Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis

1977 • 750 citations

Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

1984 • 729 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.

1985 • 589 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

Complexity of the early genetic response to growth factors in mouse fibroblasts.

1988 • 579 citations

Molecular cloning and expression of the human interferon-γ receptor

1988 • 481 citations

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

1987 • 398 citations

The primary transcription unit of the mouse β-Major globin gene

1981 • 358 citations

Inducible binding of a factor to the c-fos enhancer

1986 • 310 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

Interferon-activated genes

1986 • 301 citations

Interferon response element of the human gene 6-16.

1988 • 292 citations

A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

1989 • 262 citations

Possible involvement of protein kinase C and calcium ion in growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.

1986 • 241 citations

Activation of the human beta-interferon gene requires an interferon-inducible factor.

1986 • 237 citations

Transcriptional induction of two genes in human cells by beta interferon.

1984 • 236 citations

2-Aminopurine Selectively Inhibits the Induction of β-Interferon, c- fos , and c- myc Gene Expression

1988 • 233 citations

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.

1988 • 228 citations

Activation of the human "beta 2-interferon/hepatocyte-stimulating factor/interleukin 6" promoter by cytokines, viruses, and second messenger agonists.

1988 • 215 citations

Specific stimulation of actin gene transcription by epidermal growth factor and cycloheximide.

1984 • 215 citations

Organization of the Murine Mx Gene and Characterization of Its Interferon- and Virus-Inducible Promoter

1988 • 206 citations

Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction.

1986 • 204 citations

Interferon induction of fibroblast proteins with guanylate binding activity.

1983 • 197 citations

The catalytic subunit of cAMP-dependent protein kinase induces expression of genes containing cAMP-responsive enhancer elements

1988 • 186 citations

Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region.

1986 • 185 citations

Evidence that a human β-tubulin pseudogene is derived from its corresponding mRNA

1982 • 177 citations

Interferon-gamma modulates protein kinase C activity in murine peritoneal macrophages.

1985 • 170 citations

Two different virus-inducible elements are required for human beta-interferon gene regulation.

1989 • 168 citations

Polypeptide hormone regulation of gene expression. Thyrotropin-releasing hormone rapidly stimulates both transcription of the prolactin gene and the phosphorylation of a specific nuclear protein.

1983 • 164 citations

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.

1989 • 159 citations

Interferon-gamma-induced transcriptional activation is mediated by protein kinase C.

1988 • 137 citations

Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription.

1989 • 134 citations

Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine.

1988 • 126 citations

Hepatocyte-stimulating factor, beta 2 interferon, and interleukin-1 enhance expression of the rat alpha 1-acid glycoprotein gene via a distal upstream regulatory region.

1988 • 120 citations

Induction of HLA class II genes by IFN-gamma is transcriptional and requires a trans-acting protein.

1989 • 113 citations

New inducers revealed by the promoter sequence analysis of two interferon-activated human genes

1987 • 110 citations

Transcriptional activation of HLA-DR alpha by interferon gamma requires a trans-acting protein.

1988 • 105 citations

The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two other sites.

1988 • 102 citations

An Early Event in the Interferon-Induced Transmembrane Signaling Process

1986 • 91 citations

Cells resistant to interferon are defective in activation of a promoter-binding factor.

1988 • 83 citations

Interferon Induction by Viruses. XVI. 2-Aminopurine Blocks Selectively and Reversibly an Early Stage in Interferon Induction

1988 • 80 citations

Affinity purification of an interferon-induced human guanylate-binding protein and its characterization.

1985 • 79 citations

Interferon-gamma and interleukin-1 alpha induce transient translocation of protein kinase C activity to membranes in a B lymphoid cell line. Evidence for a protein kinase C-independent pathway in lymphokine-induced cytoplasmic alkalinization.

1988 • 75 citations

Regulation of two interferon‐inducible human genes by interferon, poly(rI) · poly(rC) and viruses

1988 • 74 citations

Differential regulation of a cellular gene by human interferon-gamma and interferon-alpha.

1988 • 56 citations

The Human Interferon‐γ Receptor System

1987 • 49 citations

Rapid and transient rise in diacylglycerol concentration in Daudi cells exposed to interferon.

1986 • 47 citations

Gene Induction by Interferons and Double-Stranded RNA: Selective Inhibition by 2-Aminopurine

1988 • 41 citations

Molecular cloning of a gene selectively induced by gamma interferon from human macrophage cell line U937.

1989 • 41 citations

Genetic analysis of the role of cAMP in mediating effects of interferon.

1982 • 40 citations

Signal transduction pathways in the induction of 2',5'-oligoadenylate synthetase gene expression by interferon alpha/beta.

1989 • 39 citations

Nonidentical Induction of the Guanylate Binding Protein and the 56K Protein by Type I and Type II Interferons

1986 • 31 citations

Interferons alpha and beta as cellular regulatory molecules.

1987 • 28 citations

Biochemical analysis of mutants of a macrophage cell line resistant to the growth-inhibitory activity of interferon.

1984 • 21 citations

Deleted Work

1955 • 0 citations