Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated.

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Mechanisms of regulation of the Na+/H+ exchanger

1986 • 685 citations

Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's

1989 • 680 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Viral oncogenes

1985 • 605 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

1986 • 477 citations

Acid and base hydrolysis of phosphoproteins bound to Immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins

1989 • 469 citations

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor

1986 • 387 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins

1985 • 331 citations

A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors

1987 • 306 citations

Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors.

1987 • 252 citations

Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies

1988 • 248 citations

Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor.

1987 • 234 citations

Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines.

1988 • 222 citations

Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine

1983 • 214 citations

Transmembrane Ion Fluxes during Activation of Human T Lymphocytes: Role of Ca²⁺, Na⁺/H⁺ Exchange and Phospholipid Turnover

1987 • 154 citations

Activation of a tyrosine protein kinase is an early event in the stimulation of T lymphocytes by interleukin-2.

1988 • 152 citations

Mitogenic stimulation of thymocytes results in the calcium-dependent phosphorylation of c-ets-1 proteins.

1988 • 118 citations

Interleukin 2 induces a rapid increase in intracellular pH through activation of a Na+/H+ antiport. Cytoplasmic alkalinization is not required for lymphocyte proliferation.

1985 • 114 citations

Epidermal growth factor receptor synthesis is stimulated by phorbol ester and epidermal growth factor. Evidence for a common mechanism.

1987 • 76 citations

Effect of interleukin 1 on the expression of interleukin 2 receptor (Tac antigen) on human natural killer cells and natural killer-like cell line (YT cells).

1986 • 74 citations

Biochemical and Molecular Events Associated with Interleukin 2 Regulation of Lymphocyte Proliferation

1986 • 70 citations

The human interleukin 2 receptor beta chain (p70). Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells.

1988 • 68 citations

Interleukin 2-dependent phosphorylation of interleukin 2 receptors and other T cell membrane proteins.

1986 • 67 citations

IL-2 regulation of tyrosine kinase activity is mediated through the p70-75 beta-subunit of the IL-2 receptor.

1989 • 65 citations

T cell antigen receptor phosphorylation induced by an anti-receptor antibody.

1987 • 53 citations

Interleukin 2 activates a receptor-associated protein kinase.

1987 • 47 citations

Direct identification of the murine IL-2 receptor p55-p75 heterodimer in the absence of IL-2.

1988 • 40 citations

Interleukin 2 and a lactogen regulate proliferation and protein phosphorylation in Nb2 cells

1988 • 40 citations

Inhibition of antibodies to CD3 surface antigen and phytohemagglutinin-mediated T cellular responses by inhibiting Ca2+/phospholipid-dependent protein kinase activity with the aid of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride.

1987 • 38 citations

Co-internalization of the p55 and p70 subunits of the high-affinity human interleukin 2 receptor. Evidence for a stable ternary receptor complex.

1988 • 35 citations

Characterization of interleukin 2-stimulated phosphorylation of 67 and 63 kDa proteins in human T-cells

1987 • 34 citations

Interleukin-2 induces rapid phosphorylation of an 85 kilodalton protein in permeabilized lymphocytes

1985 • 33 citations

Tumor-promoting phorbol ester stimulates tyrosine phosphorylation in U-937 monocytes.

1984 • 30 citations

Interleukin 2 functions through novel interleukin 2 binding molecules in T cells.

1988 • 30 citations

PMA alone induces proliferation of some murine T cell clones but not others.

1986 • 28 citations

Phorbol ester induces tyrosine phosphorylation in normal and abnormal human B lymphocytes.

1985 • 27 citations

Phorbol esters can persistently replace interleukin‐2 (IL‐2) for the growth of a human IL‐2‐dependent T‐cell line

1988 • 21 citations

Interleukin 2 (IL-2) rapidly induces phosphorylation of a cellular protein, pp67, in an IL-2 dependent murine cell line

1986 • 21 citations

Binding of interleukin 2 to its 75-kDa intermediate affinity receptor is sufficient to activate Na+/H+ exchange.

1987 • 21 citations

Interleukin 2 induces rapid phosphorylation of cellular proteins in murine T‐lymphocytes

1986 • 16 citations