The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Epidermal growth factor.

1990 • 1,645 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor

1990 • 415 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.

1988 • 250 citations

Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.

1988 • 223 citations

All Autophosphorylation Sites of Epidermal Growth Factor (EGF) Receptor and HER2/neu Are Located in Their Carboxyl-terminal Tails

1989 • 213 citations

Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex

1990 • 204 citations

Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.

1989 • 197 citations

Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates.

1990 • 193 citations

Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation.

1989 • 193 citations

Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.

1990 • 191 citations

Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.

1990 • 188 citations

A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.

1987 • 186 citations

Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.

1990 • 178 citations

Effect of Phospholipase C-γ Overexpression on PDGF-induced Second Messengers and Mitogenesis

1990 • 170 citations

Tyrosine Phosphorylation of Phospholipase C-II in Vitro by the Epidermal Growth Factor Receptor

1989 • 145 citations

Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.

1989 • 145 citations

Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells.

1990 • 136 citations

Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.

1988 • 130 citations

Identification of a novel autophosphorylation site (P4) on the epidermal growth factor receptor

1989 • 69 citations

Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation.

1989 • 54 citations

Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors.

1989 • 53 citations

Tyrosine Kinase Activity Is Essential for the Association of Phospholipase C-γ with the Epidermal Growth Factor Receptor

1990 • 41 citations

Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity.

1990 • 22 citations

Functional Heterogeneity of Proto-Oncogene Tyrosine Kinases: the C Terminus of the Human Epidermal Growth Factor Receptor Facilitates Cell Proliferation

1989 • 15 citations