Chimeric Forms of Furin and Tgn38 Are Transported from the Plasma Membrane to the Trans-Golgi Network via Distinct Endosomal Pathways

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

Rab11 regulates recycling through the pericentriolar recycling endosome.

1996 • 1,293 citations

Endocytosis

1997 • 1,263 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

1991 • 832 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells.

1983 • 636 citations

Golgi Structure in Three Dimensions: Functional Insights from the Normal Rat Kidney Cell

1999 • 621 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

Segregation of transferrin to a mildly acidic (pH 6.5) para-golgi compartment in the recycling pathway

1984 • 586 citations

Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.

1993 • 516 citations

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

1994 • 494 citations

Mannose 6-Phosphate Receptors and Lysosomal Enzyme Targeting

1989 • 473 citations

Direct Pathway from Early/Recycling Endosomes to the Golgi Apparatus Revealed through the Study of Shiga Toxin B-fragment Transport

1998 • 425 citations

Cytoplasmic dynein-dependent vesicular transport from early to late endosomes [published erratum appears in J Cell Biol 1994 Feb;124(3):397]

1993 • 408 citations

The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis.

1982 • 399 citations

Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy.

1981 • 396 citations

PACS-1 Defines a Novel Gene Family of Cytosolic Sorting Proteins Required for trans-Golgi Network Localization

1998 • 372 citations

Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38)

1990 • 355 citations

Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome.

1989 • 330 citations

Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.

1990 • 312 citations

Microtubule- and motor-dependent fusion in vitro between apical and basolateral endocytic vesicles from MDCK cells

1990 • 299 citations

Associations of elements of the Golgi apparatus with microtubules.

1984 • 291 citations

Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.

1995 • 263 citations

Intracellular movement of two mannose 6-phosphate receptors: return to the Golgi apparatus.

1988 • 263 citations

Molecular trapping of a fluorescent ceramide analogue at the Golgi apparatus of fixed cells: interaction with endogenous lipids provides a trans-Golgi marker for both light and electron microscopy.

1989 • 258 citations

Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence.

1993 • 258 citations

Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

1995 • 255 citations

Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.

1995 • 247 citations

An Endocytosed TGN38 Chimeric Protein Is Delivered to the TGN after Trafficking through the Endocytic Recycling Compartment in CHO Cells

1998 • 242 citations

Major Histocompatibility Complex Class II Compartments in Human and Mouse B Lymphoblasts Represent Conventional Endocytic Compartments

1997 • 233 citations

TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domain.

1993 • 231 citations

Intracellular movement of cell surface receptors after endocytosis: resialylation of asialo-transferrin receptor in human erythroleukemia cells.

1985 • 229 citations

Rab11, a small GTPase associated with both constitutive and regulated secretory pathways in PC12 cells

1993 • 219 citations

Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.

1986 • 217 citations

An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surface.

1995 • 215 citations

Quantification of low density lipoprotein and transferrin endocytic sorting in HEp2 cells using confocal microscopy

1994 • 212 citations

Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor.

1987 • 208 citations

Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes.

1995 • 202 citations

Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes

1992 • 187 citations

Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail.

1995 • 184 citations

Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin.

1996 • 180 citations

The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.

1994 • 169 citations

Common signals control low density lipoprotein receptor sorting in endosomes and the Golgi complex of MDCK cells

1993 • 167 citations

Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.

1991 • 162 citations

Ultrastructural localization of the mannose 6-phosphate receptor in rat liver.

1984 • 162 citations

Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro.

1996 • 156 citations

Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells.

1986 • 148 citations

Low density lipoprotein receptor and cation-independent mannose 6-phosphate receptor are transported from the cell surface to the Golgi apparatus at equal rates in PC12 cells

1992 • 147 citations

TGN38/41 recycles between the cell surface and the TGN: brefeldin A affects its rate of return to the TGN.

1993 • 143 citations

Cytoskeletal Protein ABP-280 Directs the Intracellular Trafficking of Furin and Modulates Proprotein Processing in the Endocytic Pathway

1997 • 141 citations

Regulation of protein traffic in polarized epithelial cells.

1995 • 138 citations

The TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi network.

1994 • 134 citations

Localization of Furin to the trans-Golgi Network and Recycling from the Cell Surface Involves Ser and Tyr Residues within the Cytoplasmic Domain

1995 • 131 citations

Wortmannin-sensitive Trafficking Pathways in Chinese Hamster Ovary Cells

1996 • 129 citations

The SXYQRL sequence in the cytoplasmic domain of TGN38 plays a major role in trans-Golgi network localization.

1993 • 121 citations

Phosphatidylinositol 3-kinase activity is required for early endosome fusion

1995 • 119 citations

Verotoxins and their glycolipid receptors.

1993 • 116 citations

The trans-Golgi network can be dissected structurally and functionally from the cisternae of the Golgi complex by brefeldin A.

1992 • 114 citations

Fusion accessibility of endocytic compartments along the recycling and lysosomal endocytic pathways in intact cells.

1989 • 114 citations

Intracellular trafficking of metallocarboxypeptidase D in AtT-20 cells: Localization to the Trans-Golgi network and recycling from the cell surface

1998 • 102 citations

Mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor. A consensus casein kinase II site followed by 2 leucines near the carboxyl terminus is important for intracellular targeting of lysosomal enzymes.

1993 • 100 citations

Regulation of Endosome Sorting by a Specific PP2A Isoform

1998 • 99 citations

Role of microtubules in transferrin receptor transport from the cell surface to endosomes and the Golgi complex.

1993 • 95 citations

Intracellular fusion of sequentially formed endocytic compartments.

1988 • 85 citations

COOH-terminal signals mediate the trafficking of a peptide processing enzyme in endocrine cells.

1993 • 82 citations

A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes.

1995 • 79 citations

Transport of surface mannose 6-phosphate receptor to the Golgi complex in cultured human cells

1989 • 77 citations

Isolation of a temperature‐sensitive variant Chinese hamster ovary cell line with a morphologically altered endocytic recycling compartment

1993 • 73 citations

Aggregation As a Determinant of Protein Fate in Post-Golgi Compartments: Role of the Luminal Domain of Furin in Lysosomal Targeting

1997 • 66 citations

Ultrastructural immunocytochemical localization of the phosphomannosyl receptor in Chinese hamster ovary (CHO) cells.

1983 • 61 citations

Trafficking of the epidermal growth factor receptor and transferrin in three hepatocytic endosomal fractions

1991 • 52 citations

Wortmannin Retards the Movement of the Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor and Its Ligand out of Endosomes

1998 • 51 citations

Microtubule-Disrupting Drugs Blocked Delivery of Endocytosed Transferrin to the Cytocenter, but Did Not Affect Return of Transferrin to Plasma Membrane1

1991 • 44 citations

Epitope mapping of two isoforms of a trans Golgi network specific integral membrane protein TGN38/41

1992 • 36 citations

Transferrin receptor containing the SDYQRL motif of TGN38 causes a reorganization of the recycling compartment but is not targeted to the TGN.

1996 • 35 citations

Role of Clathrin-coated Vesicles in Glycoprotein Transport from the Cell Surface to the Golgi Complex

1995 • 31 citations

Phosphatidylinositol 3-kinase is not required for recycling of mannose 6-phosphate receptors from late endosomes to the trans-Golgi network.

1997 • 29 citations

Recycling of transferrin receptors and heparan sulfate proteoglycans in a rat parathyroid cell line.

1992 • 12 citations

Comparative localization of mannose-6-phosphate receptor with 2,6sialyltransferase in HepG2 cells: an analysis by confocal double immunofluorescence microscopy.

1995 • 11 citations

Control of p62 binding to TGN38/41 by phosphorylation

1995 • 10 citations