Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

Epidermal Growth Factor

1979 • 2,964 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

1974 • 1,481 citations

Synthesis and Processing of Asparagine-Linked Oligosaccharides

1981 • 1,403 citations

The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

1984 • 1,386 citations

YOLK PROTEIN UPTAKE IN THE OOCYTE OF THE MOSQUITO AEDES AEGYPTI. L

1964 • 1,298 citations

pH and the recycling of transferrin during receptor-mediated endocytosis.

1983 • 1,165 citations

Antigen-Presenting Function of the Macrophage

1984 • 1,164 citations

Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

1976 • 1,032 citations

Mechanisms for the incorporation of proteins in membranes and organelles.

1982 • 875 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins

1985 • 845 citations

FUNCTIONS OF COATED VESICLES DURING PROTEIN ABSORPTION IN THE RAT VAS DEFERENS

1967 • 825 citations

Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor-mediated endocytosis

1983 • 816 citations

Lipoprotein receptors and cholesterol homeostasis

1983 • 755 citations

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

1977 • 688 citations

Rapid acidification of endocytic vesicles containing α2-macroglobulin

1982 • 672 citations

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells.

1983 • 636 citations

Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans

1976 • 618 citations

The Alu Family of Dispersed Repetitive Sequences

1982 • 611 citations

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

1983 • 603 citations

Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts

1981 • 593 citations

The Red Cell Membrane

1976 • 592 citations

Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues

1985 • 568 citations

Molecular cloning of cDNA encoding human interleukin-2 receptor

1984 • 567 citations

Coated vesicles from pig brain: Purification and biochemical characterization

1975 • 564 citations

Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.

1983 • 558 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

How LDL Receptors Influence Cholesterol and Atherosclerosis

1984 • 516 citations

The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains

1984 • 507 citations

Journey to the Center of the Cell: Role of the Receptosome

1981 • 500 citations

The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes

1980 • 484 citations

Mutation in LDL Receptor: Alu-Alu Recombination Deletes Exons Encoding Transmembrane and Cytoplasmic Domains

1985 • 453 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins

1978 • 430 citations

SURFACE SPECIALIZATIONS OF ABSORBING CELLS

1965 • 420 citations

Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.

1982 • 378 citations

Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

1984 • 377 citations

Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.

1983 • 369 citations

Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia.

1981 • 359 citations

Primary structure of human transferrin receptor deduced from the mRNA sequence

1984 • 351 citations

The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence

1984 • 337 citations

Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote.

1976 • 323 citations

Biosynthesis of the human transferrin receptor in cultured cells.

1981 • 316 citations

Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain

1985 • 301 citations

Endocytosis: Relation to Capping and Cell Locomotion

1984 • 292 citations

A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts

1977 • 280 citations

Visualization of lipoprotein receptors by ligand blotting.

1983 • 273 citations

Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics.

1984 • 265 citations

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

1983 • 261 citations

Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia

1982 • 245 citations

Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies.

1982 • 240 citations

Construction of influenza haemagglutinin genes that code for intracellular and secreted forms of the protein

1982 • 236 citations

THE LDL RECEPTOR LOCUS AND THE GENETICS OF FAMILIAL HYPERCHOLESTEROLEMIA

1979 • 233 citations

Receptor-mediated endocytosis: coated pits, receptosomes and the Golgi

1983 • 225 citations

Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein

1976 • 221 citations

Evidence for a Vesicular Transport Mechanism in Hepatocytes for Biliary Secretion of Immunoglobulin A

1980 • 219 citations

Primary structure of the rat liver asialoglycoprotein receptor. Structural evidence for multiple polypeptide species.

1984 • 219 citations

Computer-based characterization of epidermal growth factor precursor

1984 • 212 citations

Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts.

1978 • 211 citations

Transferrin receptor and its recycling in HeLa cells.

1982 • 206 citations

Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester.

1984 • 206 citations

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.

1979 • 186 citations

Receptor-mediated endocytosis of low density lipoprotein: somatic cell mutants define multiple genes required for expression of surface-receptor activity.

1984 • 186 citations

Cassette of Eight Exons Shared by Genes for LDL Receptor and EGF Precursor

1985 • 185 citations

The sequence and topology of human complement component C9.

1985 • 179 citations

Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation.

1984 • 178 citations

Immunoblot analysis of low density lipoprotein receptors in fibroblasts from subjects with familial hypercholesterolemia.

1982 • 175 citations

Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes

1984 • 174 citations

cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.

1983 • 168 citations

Invertase signal and mature sequence substitutions that delay intercompartmental transport of active enzyme.

1985 • 167 citations

Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9.

1984 • 160 citations

Genetics of the LDL receptor: Evidence that the mutations affecting binding and internalization are allelic

1977 • 154 citations

Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.

1984 • 151 citations

Diffusion of low density lipoprotein-receptor complex on human fibroblasts

1982 • 144 citations

Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease.

1984 • 138 citations

The antibody-induced clustering and endocytosis of HLA antigens on cultured human fibroblasts

1980 • 137 citations

Iron uptake and utilization by mammalian cells. I: Cellular uptake of transferrin and iron

1983 • 136 citations

Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein

1981 • 127 citations

Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence.

1984 • 124 citations

Spontaneous internalization of Class I major histocompatibility complex molecules in T lymphoid cells.

1984 • 120 citations

The mechanism and role of hormone-induced clustering of membrane receptors

1980 • 118 citations

Biosynthesis of the iga antibody receptor: A model for the transepithelial sorting of a membrane glycoprotein

1984 • 113 citations

A deletion that includes the signal peptidase cleavage site impairs processing, glycosylation, and secretion of cell surface yeast acid phosphatase.

1984 • 112 citations

Mode of uptake and degradation of ¹²⁵I-labelled insulin by isolated hepatocytes and H4 hepatoma cells

1979 • 94 citations

Internalization of lymphocyte membrane components

1985 • 94 citations

Evidence for different pathways for the degradation of insulin and insulin receptor in the chick liver cell.

1982 • 93 citations

Complementation of mutations in the LDL pathway of receptor-mediated endocytosis by cocultivation of LDL receptor-defective hamster cell mutants

1983 • 93 citations

Direct evidence for the transmembrane orientation of the hepatic glycoprotein receptors.

1984 • 84 citations

The appearance and internalization of transferrin receptors at the margins of spreading human tumor cells

1985 • 82 citations

Monensin inhibits receptor-mediated endocytosis of asialoglycoproteins in rat hepatocytes

1983 • 78 citations

Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts.

1983 • 77 citations

Inhibition of the binding of low‐density lipoprotein to its cell surface receptor in human fibroblasts by positively charged proteins

1978 • 77 citations

Conformational changes in the receptors for epidermal growth factor and asialoglycoproteins induced by the mildly acidic pH found in endocytic vesicles.

1984 • 67 citations

Receptor‐Mediated Transport of IgG Across the Intestinal Epithelium of the Neonatal Rat

1982 • 58 citations

Isolation of stable mouse cell lines that express cell surface and secreted forms of the vesicular stomatitis virus glycoprotein.

1983 • 55 citations

Interactions of low density lipoprotein receptors with coated pits on human fibroblasts: estimate of the forward rate constant and comparison with the diffusion limit.

1981 • 47 citations

Expression and regulation of human low-density lipoprotein receptors in Chinese hamster ovary cells

1984 • 44 citations

Kinetic defects in the processing of the low density lipoprotein receptor in fibroblasts from WHHL rabbits and a family with familial hypercholesterolemia.

1983 • 44 citations

Amphotericin B selection of mutant Chinese hamster cells with defects in the receptor-mediated endocytosis of low density lipoprotein and cholesterol biosynthesis.

1983 • 42 citations

Co-clustering and internalization of low-density lipoproteins and α2-macroglobulin in human skin fibroblasts

1982 • 40 citations

Homozygous familial hypercholesterolemia mutant with a defect in internalization of low density lipoprotein.

1981 • 40 citations

Coated pits in action

1984 • 38 citations

Dynamics of low-density lipoprotein receptors in the plasma membrane of cultured human skin fibroblasts as visualized by colloidal gold in conjunction with surface replicas.

1983 • 25 citations

The intracellular traffic of immunologically active molecules

1984 • 19 citations

Ciba Foundation Symposium 92 ‐ Membrane Recycling

1982 • 13 citations

Biochemical genetics of LDL receptor mutations in familial hypercholesterolemia.

1982 • 11 citations

RECEPTOR-MEDIATED UPTAKE OF MACROMOLECULES AND THEIR DELIVERY TO LYSOSOMES IN HUMAN FIBROBLASTS

1978 • 11 citations

Dynamics of MHC Molecules in Lymphoid Cells: Facts and Speculations

1985 • 8 citations