The SXYQRL sequence in the cytoplasmic domain of TGN38 plays a major role in trans-Golgi network localization.

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

1990 • 918 citations

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

1991 • 832 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking.

1991 • 552 citations

ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway

1990 • 548 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

The retention signal for soluble proteins of the endoplasmic reticulum

1990 • 531 citations

Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

1990 • 508 citations

The Golgi complex: In vitro veritas?

1992 • 481 citations

Mannose 6-Phosphate Receptors and Lysosomal Enzyme Targeting

1989 • 473 citations

Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum

1992 • 396 citations

Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes

1991 • 378 citations

Basolateral sorting of LDL receptor in MDCK cells: The cytoplasmic domain contains two tyrosine-dependent targeting determinants

1992 • 366 citations

Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38)

1990 • 355 citations

The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence

1984 • 337 citations

A human homologue of the yeast HDEL receptor

1990 • 336 citations

Basolateral sorting in MDCK cells requires a distinct cytoplasmic domain determinant

1991 • 304 citations

Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention.

1991 • 296 citations

Plasma membrane protein sorting in polarized epithelial cells.

1992 • 272 citations

Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail.

1990 • 272 citations

Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence.

1993 • 258 citations

A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin.

1991 • 257 citations

The ERD2 gene determines the specificity of the luminal ER protein retention system

1990 • 243 citations

The membrane spanning domain of beta-1,4-galactosyltransferase specifies trans Golgi localization.

1991 • 237 citations

Perturbation of the morphology of the trans-Golgi network following Brefeldin A treatment: redistribution of a TGN-specific integral membrane protein, TGN38.

1992 • 226 citations

The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi.

1992 • 225 citations

Recycling of proteins between the endoplasmic reticulum and Golgi complex

1991 • 194 citations

A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein.

1991 • 185 citations

Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes.

1990 • 185 citations

Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion.

1985 • 182 citations

Golgi retention of a trans-Golgi membrane protein, galactosyltransferase, requires cysteine and histidine residues within the membrane-anchoring domain.

1992 • 162 citations

Molecular cloning, characterization, subcellular localization and dynamics of p23, the mammalian KDEL receptor.

1993 • 154 citations

An internal deletion in the cytoplasmic tail reverses the apical localization of human NGF receptor in transfected MDCK cells.

1991 • 153 citations

The signal for Golgi retention of bovine beta 1,4-galactosyltransferase is in the transmembrane domain.

1992 • 148 citations

A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1

1992 • 148 citations

TGN38/41 recycles between the cell surface and the TGN: brefeldin A affects its rate of return to the TGN.

1993 • 143 citations

Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus.

1990 • 138 citations

The signal anchor and stem regions of the beta-galactoside alpha 2,6-sialyltransferase may each act to localize the enzyme to the Golgi apparatus.

1992 • 134 citations

The 17-residue transmembrane domain of beta-galactoside alpha 2,6-sialyltransferase is sufficient for Golgi retention

1992 • 126 citations

Isolation and characterization of human glycophorin A cDNA clones by a synthetic oligonucleotide approach: nucleotide sequence and mRNA structure.

1986 • 125 citations

Signals for retention of transmembrane proteins in the endoplasmic reticulum studied with CD4 truncation mutants.

1991 • 122 citations

Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain.

1990 • 121 citations

The trans-Golgi network can be dissected structurally and functionally from the cisternae of the Golgi complex by brefeldin A.

1992 • 114 citations

The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.

1992 • 105 citations

Beta 1,4-galactosyltransferase: a short NH2-terminal fragment that includes the cytoplasmic and transmembrane domain is sufficient for Golgi retention.

1992 • 100 citations

The transmembrane and flanking sequences of beta 1,2-N-acetylglucosaminyltransferase I specify medial-Golgi localization.

1992 • 92 citations

The cytoplasmic domain of the polymeric immunoglobulin receptor contains two internalization signals that are distinct from its basolateral sorting signal.

1992 • 90 citations

The transmembrane domain of N-glucosaminyltransferase I contains a Golgi retention signal.

1992 • 84 citations

The pathway and targeting signal for delivery of the integral membrane glycoprotein LEP100 to lysosomes.

1992 • 61 citations

Protein trafficking along the exocytotic pathway

1993 • 55 citations

Expression of human glycophorin A in wild type and glycosylation-deficient Chinese hamster ovary cells. Role of N- and O-linked glycosylation in cell surface expression.

1991 • 50 citations

Involvement of both vectorial and transcytotic pathways in the preferential apical cell surface localization of rat dipeptidyl peptidase IV in transfected LLC-PK1 cells.

1991 • 22 citations

Biogenesis of glycophorin A in K562 human erythroleukemia cells.

1987 • 19 citations

Golgi-localized beta-galactoside alpha 2,6-sialyltransferase in transfected CHO cells is redistributed into the endoplasmic reticulum by brefeldin A.

1992 • 9 citations