Wortmannin Retards the Movement of the Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor and Its Ligand out of Endosomes

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

1996 • 531 citations

Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation

1985 • 448 citations

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1994 • 362 citations

Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes to the trans-Golgi network.

1994 • 306 citations

Characterization of protein transport between successive compartments of the Golgi apparatus: Asymmetric properties of donor and acceptor activities in a cell-free system

1985 • 301 citations

Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Linase Binding Sites

1994 • 297 citations

Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis

1989 • 272 citations

Mannose-6-phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes.

1986 • 270 citations

Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.

1995 • 263 citations

Intracellular movement of two mannose 6-phosphate receptors: return to the Golgi apparatus.

1988 • 263 citations

Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

1995 • 255 citations

Mannose 6-phosphate receptors in sorting and transport of lysosomal enzymes

1995 • 245 citations

Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicles.

1988 • 241 citations

A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function.

1992 • 205 citations

Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes.

1995 • 202 citations

Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin.

1996 • 180 citations

Selective recycling of the mannose 6-phosphate/IGF-II receptor to the trans Golgi network in vitro

1988 • 177 citations

The effect of wortmannin on the localisation of lysosomal type I integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocytic pathway

1996 • 175 citations

Differential subcompartmentation of terminal glycosylation in the Golgi apparatus of intestinal absorptive and goblet cells.

1986 • 172 citations

Phosphatidylinositol 3-Kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking

1995 • 165 citations

Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells.

1991 • 164 citations

Characterization of the cation-independent mannose 6-phosphate receptor-enriched prelysosomal compartment in NRK cells

1990 • 161 citations

Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro.

1996 • 156 citations

Characterization of the signal for rapid internalization of the bovine mannose 6-phosphate/insulin-like growth factor-II receptor.

1992 • 144 citations

Requirement for Phosphoinositide 3-Kinase in Insulin-Stimulated GLUT4 Translocation in 3T3-L1 Adipocytes

1995 • 143 citations

Wortmannin-sensitive Trafficking Pathways in Chinese Hamster Ovary Cells

1996 • 129 citations

Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes?

1987 • 123 citations

Phosphatidylinositol 3-kinase activity is required for early endosome fusion

1995 • 119 citations

Wortmannin, an Inhibitor of Phosphoinositide 3-Kinase, Inhibits Transcytosis in Polarized Epithelial Cells

1995 • 112 citations

The site of incorporation of sialic acid residues into glycoproteins and the subsequent fates of these molecules in various rat and mouse cell types as shown by radioautography after injection of [3H]N-acetylmannosamine. I. Observations in hepatocytes.

1981 • 99 citations

Structural studies of the phosphorylated high mannose-type oligosaccharides on human beta-glucuronidase.

1982 • 98 citations

Identification of subcellular compartments involved in biosynthetic processing of cathepsin D.

1992 • 90 citations

A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes.

1995 • 79 citations

Transport of surface mannose 6-phosphate receptor to the Golgi complex in cultured human cells

1989 • 77 citations

Inhibitors of Phosphoinositide 3-Kinase Block Exocytosis but Not Endocytosis of Transferrin Receptors in 3T3-L1 Adipocytes

1995 • 72 citations

Expression of human cation-independent mannose 6-phosphate receptor cDNA in receptor-negative mouse P388D1 cells following gene transfer.

1988 • 51 citations

Dissociation kinetics of 125I-nerve growth factor from cell surface receptors. Acceleration by unlabeled ligand and its relationship to negative cooperativity.

1981 • 50 citations

Inhibition of Calcium-independent Mannose 6-Phosphate Receptor Incorporation into trans-Golgi Network-derived Clathrin-coated Vesicles by Wortmannin

1997 • 33 citations

Phosphatidylinositol 3-kinase is not required for recycling of mannose 6-phosphate receptors from late endosomes to the trans-Golgi network.

1997 • 29 citations

Inhibition of IGF II-induced redistribution of mannose 6-phosphate receptors by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1996 • 10 citations

A Chinese hamster ovary cell line with a temperature-conditional defect in receptor recycling is pleiotropically defective in lysosome biogenesis.

1993 • 10 citations

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